The a16z Show

with Andrew Lo (@AndrewWLo) and Jorge Conde (@JorgeCondeBio) The advent of new gene and cell therapies are beginning to approach that holy grail of medicine—that of a possible cure. But they are also more expensive than any medicines ever sold before. In this episode, MIT economist Andrew Lo and a16z General Partner on the Bio Fund Jorge Conde discuss how exactly we place an economic value on a cu...

with Laurene Powell Jobs (@LaurenePowell) and Ben Horowitz (@bhorowitz) Laurene Powell Jobs is, among many other things, founder and President of the Emerson Collective -- the social impact firm she founded to drive change and reform through philanthropy, investing, and policy solutions. In this episode of the a16z Podcast, Ben Horowitz interviews Powell Jobs on everything from what made her who s...

with David Ulevitch (@davidu) and Sonal Chokshi (@smc90) Since the startup (and founder) journey doesn't go neatly linear from technical to product to sales, tightening one knob (whether engineering or marketing or pricing & packaging) creates slack in one of the other knobs, which demands turning to yet another knob. So how do you know what knob to focus on and when? How do you build the righ...

Do you sometimes wish you had been born in a different decade so you could have worked on the fundamental building blocks of modern computing? How fun, challenging, and fulfilling would it have been to work on semiconductors in the 1950s or Unix in the 1960s (both at Bell Labs) or personal computers at the Homebrew Computer Club in the 1970s or on the Internet browser at the University of Illinois...

with Emily Oster (@ProfEmilyOster) and Hanne Tidnam (@omnivorousread) Are chia seeds actually that good for you? Will Vitamin E keep you healthy? Will breastfeeding babies make them smarter? There’s maybe no other arena where understanding what the evidence truly tells us is harder than in health… and parenting. And yet we make decisions based on what we hear about in studies like the ones listed...

with @annieduke, @pmarca, and @smc90 Every organization, whether small or big, early or late stage -- and every individual, whether for themselves or others -- makes countless decisions every day, under conditions of uncertainty. The question is, are we allowing that uncertainty to bubble to the surface, and if so, how much and when? Where does consensus, transparency, forecasting, backcasting, pr...

In a followup to one of our most popular podcast episodes which originally aired in April 2017 (https://a16z.com/2017/04/03/cryptocurrencies-protocols-appcoins/), a16z Crypto Fund General Partner Chris Dixon returns to talk with Olaf Carlson-Wee of Polychain Capital in a free-wheeling conversation about the seven major trends they see happening in blockchain computing now as we shift from basic pr...

As companies digitize, they change the way they make decisions: decisions are made lower in the organization, based on data, and increasingly automated. This creates opportunities for startups creating new ways to collect and analyze data to support this new style of decision making. In this episode (which originally aired as a YouTube video), Jad Naous (@jadtnaous) ‏and Frank Chen (@withfries2) d...

with Jorge Conde (@JorgeCondeBio), Julie Yoo (@julesyoo), and Hanne Tidnam (@omnivorousread) Building a software company in healthcare is hard -- and comes along with unique challenges no other entrepreneurs face. In this conversation, a16z bio general partner -- and previous founder of genomics company Knome -- Jorge Conde; and a16z bio partner and former founder Julie Yoo (of patient provider ma...

Join longtime Apple software engineer Ken Kocienda in conversation with a16z Deal and Research operating partner Frank Chen for an insider’s account of how Apple designed software in the golden age of Steve Jobs, spanning products like the first release of Safari on MacOS to the first few releases of the iPhone and iOS (very first codename: "Purple"). Ken vividly shares about the creativ...

In this episode of the a16z Podcast -- which originally aired as a video on YouTube -- general partner Alex Rampell (and former fintech entrepreneur as the CEO and co-founder of TrialPay) talks with operating partner Frank Chen about the quickly changing fintech landscape and, even more importantly, why the landscape is changing now. Should the incumbents be nervous? About what, exactly? And most...

with Nick Quah (@nwquah), Connie Chan (@conniechan), and Sonal Chokshi (@smc90) It's a podcast about podcasting! About the state of the industry, that is. Because a lot has changed since we recorded "a podcast about podcasts" about four years ago: podcasts, and interest in podcasting -- listening, making, building -- is growing. But by how much, exactly? (since various stats are constant...

with Benedict Evans (@benedictevans) and Steven Sinofsky (@stevesi) What does Apple's recent event — in which a range of new services was announced, from Apple News Plus to Apple TV Plus to the Apple card — mean for the company's overall strategy and tactics? In this another of a16z's 'hallway conversations', Benedict Evens and Steven Sinofsky discuss the build up, announcements, and postmortem of...

with Safi Bahcall (@safibahcall), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) A "moonshot" is a destination (like going to the moon, quite literally) -- but nurturing "loonshots" (which often involves a number of stumbles along the way) is how we get there. This goes beyond the trite mantra of failing fast! It is about not having "false fails" or not killing...

with Brian Koppelman (@briankoppelman), Marc Andreessen (@pmarca), and Sonal Chokshi (@smc90) The writer-showrunner is a relatively new phenomenon in TV, as opposed to film, which is still a director-driven enterprise. But what does it mean, as both a creative and a leader, to “showrun” something, whether a TV show… or a startup? Turns out, there are a lot of parallels with the rise of the showrun...

When people talk about trends in education technology, they often focus on how to disrupt higher education in the U.S., whether it's about breaking free of the "signaling" factor of elite educations or how to shift education out of its "cottage industry" mindset to achieve greater scale. However, in China, the transformation of education is already well underway, with a fast-gr...

with George Church (@geochurch) and Jorge Conde (@JorgeCondeBio) Renowned scientist George Church is known for his groundbreaking work and methods used for the first genome sequence, and for his work in genome editing, writing & recoding -- in fact, Church’s innovations have become an essential building block for most of the DNA sequencing methods and companies we see today. In this conversati...

with Peter Ludwig, Qasar Younis (@qasar), and Sonal Chokshi (@smc90) When people talk about autonomous vehicles, we hear everything from "we're much closer than you think" to "we're much further than you think". So where are we, really, in the widespread reality of autonomous vehicles today? It depends, of course, on how you define autonomy -- which is where a handy recap and u...

Bobby Kotick is the CEO of Activision Blizzard (a merger he engineered); it's one of only two video gaming companies in the Fortune 500, and the largest game network in the world. The company is responsible for some of the most iconic entertainment franchises, including Call of Duty, Candy Crush, Overwatch, and World of Warcraft -- as well as its own professional esports league. So in this episode...

with Ryan Caldbeck (@ryan_caldbeck), Jeff Jordan (@jeff_jordan), and Sonal Chokshi (@smc90) It's clear that all kinds of commerce companies and consumer products have been disrupted -- or enabled -- by tech. Yet for certain categories, like consumer packaged goods (CPG), it seems like tech hasn't changed things very much. How is the rise of so-called "micro-brands" (or emerging brands) p...

with Kate Darling (@grok_) and Hanne Tidnam (@omnivorousread) We already know that we have an innate tendency to anthropomorphize robots. But beyond just projecting human qualities onto them, as we begin to share more and more spaces, social and private, what kind of relationships will we develop with them? And how will those relationships in turn change us? In this Valentine’s Day special, Kate D...

with Chris Burniske (@cburniske), Joel Monegro (@jmonegro), Denis Nazarov (@Iiterature), and Jesse Walden (@jessewldn) When designing cryptonetworks -- really, emerging economies -- how do we avoid some of the monetary and fiscal policy failings of "real-world" economies? Like not separating currency and capital, which accelerated and spread economic growth through the former... but also...

with Phil Daian (@phildaian) and Ali Yahya (@ali01) Whether in corporations, boardrooms, or political elections, voting is something we see in all kinds of social systems... including blockchains. It's the natural human tendency for how to organize decisions, and in distributed systems without centralized middlemen, it's the only clear Schelling point we can come up with. But too many people desig...

with Jyoti Bansal (@jyotibansalsf), Peter Levine, Satish Talluri (@satishtalluri), and Sonal Chokshi (@smc90) One of the toughest challenges for founders -- and especially technical founders who are used to focusing so much on product features over sales -- is striking "product-market fit". The concept can be defined many ways, but the simple definition shared in this episode is: it's wh...

with Mark Leslie (@mleslie45) and Peter Levine What does it actually take to win at enterprise sales? In this episode, Mark Leslie, former CEO and chairman and founding team member of Veritas Software, and a lecturer at the Stanford Graduate School of Business, and a16z general partner Peter Levine -- who worked together at Veritas -- share stories from the field all about sales and entrepreneursh...