The a16z Show

with Peter Levine, Bob Tinker, and Hanne Tidnam (@omnivorousread) For consumer companies, often when the holy grail of product-market fit is achieved, the company takes off: magic happens, growth unlocks. Enterprise B2B companies face a different challenge. Sometimes, despite achieving product-market fit (and knowing when you've achieved it) and winning your first cohorts of renewing customers --...

Veterinary oncology can inform human oncology, and vice versa -- providing a better model for looking at drug performance, interrelationships, and more. Especially when you add in data (there's no "doggy HIPAA!") and networks to get a "living laboratory at scale". Or so argues Amy Abernethy (Chief Medical and Chief Scientific Officer at Flatiron Health and advisor to One Health...

with Joel de la Garza, Jonathan Lusthaus, and Hanne Tidnam (@omnivorousread) The idea of the cybercriminal as lone wolf or hobby hacker is no longer much of a reality. Instead, the business of cybercrime looks a lot more just like that -- a large, global technology business, with many of the associated structures, challenges, and even casts of characters that legitimate businesses have. In this co...

with Benedict Evans (@benedictevans) and Steven Sinofsky (@stevesi) Every year, the Consumer Electronics Show (CES) puts the latest and greatest developments in consumer technology on display in Vegas. But beyond the excitement and the hype, what's really here -- or not here -- to stay? Will televisions roll up into tiny boxes? Will Alexa find her way into electric carving knives? Which of these n...

with Susannah Fox (@susannahfox), Anil Sethi (@anilsethiusa / @ciitizencorp), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) The problem of "dark data" in healthcare isn't just a feel-good empowerment thing, but a structural issue that leads to miscommunication and extra friction, different players in the entire healthcare system not being able to collaborate with each other, and...

with Vas Narasimhan (@vasnarasimhan), Jorge Conde (@jorgecondebio), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) On average, only 1 out of 20 medicines works when we actually bring them into the human body, and these rates of success haven't moved much in the pharma industry overall in the past 15 years, despite much scientific progress. Because if you really think about it, it's incredib...

with James J. Collins, Vijay Pande (@vijaypande), and Hanne Tidnam (@omnivorousread) The idea of 'designing biology' -- once science fiction -- has over the last 20 years become just... science. In this episode, a16z bio general partner Vijay Pande with Hanne Tidnam talk all about the field of synthetic biology with James J. Collins, professor of bioengineering at MIT. Collins, whose work in synth...

The past and future of marketplace startups -- where are we? Ever since eBay popularized an internet meeting place for buyers and sellers of, well, just about everything, we’ve been waiting for 100 other at-scale marketplaces for everything else, including services. So in this hallway-style episode of the a16z Podcast (originally recorded as a video) Li Jin -- co-author with Andrew Chen of this po...

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Tyler Cowen (@tylercowen) This episode of the a16z Podcast features the rare combination of a16z co-founders Marc Andreessen and Ben Horowitz in conversation, together, with economist Tyler Cowen (chair of economics at George Mason University and chairman and general director of the Mercatus Center there, and host of his own podcast.)...

In his book (and podcast), Brian McCullough chronicles the history and evolution of the internet -- from college kids in a basement and the dot-com boom, to the applications built on top of it and the entrepreneurs behind them. General partner Chris Dixon chats with McCullough about How the Internet Happened -- and more broadly, about how tech adoption and innovation happens. The content provided...

with Andy Milenius (@realzandy), Jesse Walden (@jessewldn), and Sonal Chokshi (@smc90) The history, evolution, and use of money revolves around the important concept of debt: It’s what allows us to “time travel” and build toward the future — growing livelihoods, businesses, and the overall economy as a result. When it comes to crypto, however, this concept plays a key role as a way to potentially...

with Bernard J. Tyson (@bernardjtyson) and Ben Horowitz (@bhorowitz) Bernard J. Tyson is the chairman and CEO of Kaiser Permanente, a $73 billion non-profit health organization that provides healthcare and coverage with more than 22,000 physicians caring for more than 12.2 million members across 9 states. In  this conversion with a16z co-founder and general partner Ben Horowitz -- which originally...

with Brian Armstrong (@brian_armstrong), Chris Dixon (@cdixon), and Sonal Chokshi (@smc90) Where are we, really, right now -- in terms of what we can/ can't do with crypto today? And what will it take to get from vision to mainstream reality? This episode of the a16z Podcast covers all this and more. It's based on a conversation that took place between Coinbase CEO and cofounder Brian Armstrong an...

with Jeffrey Katzenberg, Meg Whitman (@MegWhitman), and Marc Andreessen (@pmarca) In this episode of the a16z Podcast, based on a discussion that took place at our annual a16z Summit, Marc Andreessen interviews Jeffrey Katzenberg -- formerly CEO and co-founder of DreamWorks SKG (and chairman of Walt Disney Studios during some of its biggest hits), now co-founder of tech holding company WndrCo -- a...

with Boris Sofman (@bsofman), Dave Touretzky (@DaveTouretzky), and Hanne Tidnam (@omnivorousread) We're just now beginning to truly see the the first 'real' robots in the home, from Roombas to toys to companions to... well, much more. How are humans beginning to forge relationships with these robotic devices (/entities!) -- and how will those relationships develop? What do we learn as we begin to...

with Adrienne Mayor (@amayor) and Hanne Tidnam (@omnivorousread) Is it possible that ancient Greeks and Romans dreamed of technological innovations like robots and artificial intelligence millennia before those technologies became realities? In this episode of the a16z Podcast, Adrienne Mayor, historian of science and author of the just released Gods & Robots: Myths, Machines, and Ancient Drea...

with Stephanie Cohen and Martin Casado (@martin_casado) As chief strategy officer of Goldman Sachs (and former global head of financial sponsors M&A), Stephanie Cohen has seen it all when it comes to the ins and outs of M&A. And what it means to innovate from within, especially at a large company. Given Cohen's unique vantage point and nearly 20-year tenure at Goldman Sachs, Casado -- hims...

with Prasad Akella, Paul Daughtery (@pauldaugh) and Frank Chen (@withfries2) What is different on that factory floor from Henry Ford to today? In this conversation, Prasad Akella, Founder and CEO of Drishti; Paul Daugherty, Chief Technology and Innovation Officer of Accenture, and author of the recently published Human + Machine: Reimagining Work in the Age of AI; and a16z operating partner Frank...

with Jeff Jordan (@Jeff_Jordan), Yogi Roth (@YogiRoth), Zack Weiner and Hanne Tidnam (@omnivorousread) For decades, the increasing value of sports teams, rights, licenses and more have been fueled by sports media. But dollars follow eyeballs, and eyeballs -- at least on the traditional broadcast -- are going elsewhere. "If you don't know where you are going, you'll end up someplace else,” Yog...

The period from 2000-2016 was one of the best of times and worst of times for tech and the Valley (dotcom, financial crisis, Google IPO, Facebook founded, unprecedented growth, and so on), and John Hennessy -- current chairman of Alphabet, also on the boards of Cisco and other organizations -- was the president of Stanford University during that entire time. Given this vantage point, what are his...

with Shannon (Stubo) Brayton (@sstubo), Margit Wennmachers (@wennmachers), and Sonal Chokshi (@smc90) One of the company building topics that’s surprisingly mystifying is PR -- and only surprising since so much of the strategy and tactics behind public relations are actually hidden from public view. We've tried demystifying the topic in an ongoing series, covering everything from "the why, ho...

with Michael Ovitz (@michaelovitz), Ben Horowitz (@bhorowitz), and Hanne Tidnam (@omnivorousread) When Michael Ovitz co-founded the Hollywood talent agency Creative Artists Agency (CAA), he turned a number of the entertainment industry's well-entrenched traditions on their head. The origin story of a16z (not coincidentally!) is not that dissimilar. So in this episode of the a16z Podcast, Ovitz and...

with Fred Wilson (@fredwilson) and Chris Dixon (@cdixon) There's all sorts of interesting tech trends happening right now, including AI, VR/AR, self-driving cars and drones (as well as interesting stuff happening in verticals like healthcare and finance) -- and there's a lot also happening in seemingly more "mature" tech revolutions, such as mobile and cloud. But where are we now, really...

with Benedict Evans (@BenedictEvans) and Steven Sinofsky (@SteveSi) In another of our hallway conversation episodes, Benedict Evans and Steven Sinofsky talk all about Tesla — and more broadly, the nature of disruption overall. How disruptive is Tesla really, and what exactly are they disrupting — from the dashboard to car makers to vendors to energy source to autonomy overall? The tech industry is...

with Benedict Evans (@BenedictEvans) and Steven Sinofksy (@StevenSi) In this hallway-style conversation episode of the a16z Podcast, Benedict Evans and a16z board partner Steven Sinofsky discuss Apple’s September 2018 keynote event and share their thoughts on the new innovations -- and lessons -- that really matter. With something that’s gone from toy to phone to fashion item -- and just pivoted t...