Surfing the MASH Tsunami

Send us Fan Mail This conversation includes part of a more extended discussion that Donna Cryer had with Louise Campbell and Roger Green when she stopped by the virtual SurfingNASH.com studios to discuss her recent work. Donna starts her conversation by saying that she is bringing three pieces of news with her. The first: with support from Novo Nordisk, the National Committee for Quality Assurance...

Send us Fan Mail This conversation includes part of a more extended discussion that Naim Alkhouri had with Louise Campbell and Roger Green when he stopped by the virtual SurfingNASH.com studios to discuss his recent work. This conversation winds up focusing on digital health and future therapies, but it starts down a funny path on the way there. Louise Campbell returns to the question of CAP score...

Send us Fan Mail This conversation includes part of a longer discussion that Naim Alkhouri had with Louise Campbell and Roger Green when he stopped by the virtual SurfingNASH.com studios to discuss his recent work. Naim dives right into the conversation by mentioning that he has had two papers published within the last week or two. One is from the EDICT Trial, a multi-year evaluation of Type 2 Dia...

Send us Fan Mail This conversation on NAFLD Care Delivery and NASH practices comes from Episode 20, our introductory conversation with newly designated full-time co-host Jörn Schattenberg. Most of the conversation focused on Jörn's background and research interests, but this section explores ways we can provide better diagnosis, coaching and care for Fatty Liver patients in Germany, the UK an...

Send us Fan Mail Arizona Liver Health Institute V.P. of Academic Affairs and Fatty Liver Program Director Naim Alkhouri and Global Liver Institute Founder and CEO Donna Cryer join Louise Campbell and Roger Green to discuss their recent projects and accomplishments. Each of them brings newsworthy stories that lead to thoughtful, stimulating conversations about a range of issues. Naim Alkhouri'...

Send us Fan Mail SurfingNASH.com has produced this special, single-interview episode to give listeners a chance to learn about Jörn Schattenberg in a different way as he becomes the permanent Key Opinion Leader on Surfing the NASH Tsunami. Surfing the NASH Tsunami's "Seasons" start with the calendar year, but our first episode posted on April 15, 2020. As we begin our third year, we...

Send us Fan Mail This conversation starts with Stephen Harrison discussing the scope of current NITs in the context of what NAIL-NIT needs to achieve. "We don't need to reinvent the wheel, " he says, "only to make it run smoother." After Naim Alkhouri and Mazen Noureddin discuss the Phase I facilities they are building for future research, the group closes the conversation...

Send us Fan Mail This conversation starts with discussing how challenging it was to develop initial FDA test criteria for evaluating NASH drugs. Many years later, he notes, we have learned how flawed these criteria were, several in ways we cannot fix, but we need to do better. He relates this to what the British author Rupert Sheldrake describes as "morphic resonance" or mysterious telep...

Send us Fan Mail This conversation starts with Naim Alkhouri and Jörn Schattenberg defining the wealth of data resources and hypotheses they are bringing to their roles as co-leads of retrospective analysis for NAIL-NIT. Mazen Noureddin then asks each of them to describe his "passionate first project." This leads Naim to discuss drug evaluation principles he finds so counterproductive th...

Send us Fan Mail In this brief conversation, Stephen Harrison discusses the exciting goal and ambitious research plan for NAIL-NIT, after which Mazen Noureddin describes the patient-focused issues and conference conversations that motivated Stephen and Mazen to form and recruit members for this consortium. It is a short but rich listen that will help you understand exactly what NAIL-NIT is driving...

Send us Fan Mail This week marks the 2nd anniversary for Surfing the NASH Tsunami! This conversation celebrates our anniversary and brings news about the formation of a new company dedicated to using podcasts and related media to put big dent in Fatty Liver disease and changing roles for co-founder Stephen Harrison and "fifth Beatle" Jörn Schattenberg. Before you listen, you might want t...

Send us Fan Mail This 2nd Anniversary episode focuses on what the retrospective analysis from the NAIL-NIT consortium can achieve in terms of driving the shift beyond the biopsy in NASH diagnostics while simultaneously celebrating Stephen Harrison's contribution to the podcast while announcing that Jörn Schattenberg will become our weekly Key Opinion Leader (other commitments will force Steph...

Send us Fan Mail This week's episode and conversations preview the inaugural Innovations in NAFLD Care Workshop, premiering in Barcelona on May 6 and 7. Surfing the NASH Tsunami is a Media Partner for this conference. We will be conducting and posting interviews from the conference, co-host Roger Green is moderating a panel there, and Surfing NASH will present a follow-up episode on Wednesday...

Send us Fan Mail This week's episode and conversations preview the inaugural Innovations in NAFLD Care Workshop, premiering in Barcelona on May 6 and 7. Surfing the NASH Tsunami is a Media Partner for this conference. We will be conducting and posting interviews from the conference, co-host Roger Green is moderating a panel there, and Surfing NASH will present a follow-up episode on Wednesday...

Send us Fan Mail This week's episode and conversations preview the inaugural Innovations in NAFLD Care Workshop, premiering in Barcelona on May 6 and 7. Surfing the NASH Tsunami is a Media Partner for this conference. We will be conducting and posting interviews from the conference, co-host Roger Green is moderating a panel there, and Surfing NASH will present a follow-up episode on Wednesday...

Send us Fan Mail This week's episode and conversations preview the inaugural Innovations in NAFLD Care Workshop, premiering in Barcelona on May 6 and 7. Surfing the NASH Tsunami is a Media Partner for this conference. We will be conducting and posting interviews from the workshop, co-host Roger Green is moderating a panel there, and Surfing NASH will present a follow-up episode on Wednesday,...

Send us Fan Mail Conference founders and directors Jeffrey Lazarus and Jörn Schattenberg join Roger Green to preview the inaugural Innovations in NAFLD Care 2022 conference, scheduled for May 6 and 7 In Barcelona and on-line. Jeff Lazarus describes this conference as "looking at Fatty Liver disease from a Public Health perspective." As Jörn Schattenberg expressed, this has been a process...

Send us Fan Mail Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in the basic science and technology of defining, diagnosing and treating NAFLD and NASH. This conversation focuses largely on questions of how hepatic cells regenerate and what more we can learn about this phenomenon over time as technolo...

Send us Fan Mail Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in the basic science and technology of defining, diagnosing and treating NAFLD and NASH. This conversation focuses largely on the spatial transcriptomics: its history, what it can tell us today, and how it might improve even further over...

Send us Fan Mail Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in the basic science and technology of defining, diagnosing and treating NAFLD and NASH. This conversation focuses largely on the implications of potentially exciting future technologies such as the mRNA/CAR-T therapy described in Convers...

Send us Fan Mail Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in the basic science and technology of defining, diagnosing and treating NAFLD and NASH. This conversation focuses largely on mRNA/CAR-T anti-fibrotic therapies. Scott Friedman starts this conversation by reviewing the historical sequence...

Send us Fan Mail Professors Scott Friedman and Neil Henderson join the Surfers (including the returning Stephen Harrison) to discuss some truly exciting advances in advanced NASH omics, including work on mRNA/CAR-T anti-fibrotic therapies.  There is not enough room to capture this entire conversation in a summary. It's a lot, but really eye-opening and exciting. Take the time to listen to the...

Send us Fan Mail The conversation was originally recorded on January 27, 2022. It focuses on use of MR Elastography to diagnose, treat and monitor NASH patients in an outpatient setting through two uses of MRE -- the MAST test, which includes MRE, MRI-PDFF and AST and the basic Hepatogram test, which includes MRE and MRI-PDFF, or, as Mazen Noureddin describes it during the conversation, MREFF. Thi...

Send us Fan Mail This conversation starts by focusing on issues related to diagnostic testing and what we attempt to detect or prove with each test. It starts with Roger Green noting the challenge of widespread population testing for fast progressors: the easy, inexpensive test for widespread 1st-line population testing is FIB-4, but FIB-4's lack of positive predictive value makes it a poor t...

Send us Fan Mail This conversation explores the impact some suggestions and questions that arose at Liver Connect might have on data modeling. Roger Green starts by mentioning that the Liver Connect panels felt that waist circumference measurement might be a better treatment/diagnostic metric than BMI, since it reflects both fat distribution within the body and region of the world. The group gener...