Straight Shot with Dr. Clete Barrick

What do GLP-1s do to your reproductive health? Today we cover birth control, pregnancy, polycystic ovary syndrome (PCOS), menopause and testosterone, plus a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is reproductive health, for women...

What do GLP-1s do to your gut? Today we cover the everyday side effects, the rare ones, what helps, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the gut. In this episode: - The everyday side effects: nausea in 44% at 2.4 mg of...

What do GLP-1s do to your brain? Today we cover brain benefits, harms, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the brain. In this episode: - How a GLP-1 reaches your brain: semaglutide does not cross the blood-brain barrie...

What do GLP-1s do to your kidneys? Today we cover the benefits, harms, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the kidney. In this episode: - FLOW, the only trial in this class built to test the kidney: semaglutide cut kid...

What do GLP-1s do to your heart? Today we cover cardiac benefits, harms, and a verdict, built from a full literature review. Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, continues Season 2 of Straight Shot: every organ, one episode at a time. This one is the heart. In this episode: - Heart-safety trials the Food and Drug Administration (the FDA) required showed...

What do GLP-1s do to your liver? We cover the benefits, harms, and a verdict, all built from a 94-source literature review.  Dr. Clete Barrick MD, board-certified in internal medicine and obesity medicine, founder of Barrick Health, 5,000+ GLP-1 patients, 95 lbs lost on tirzepatide, opens Season 2 of Straight Shot: every organ, one episode at a time, starting with the liver. In this episode: - Fat...

Twelve thousand researchers. Hundreds of presentations. Five studies that matter. Dr. Clete Barrick breaks down the most important GLP-1 research presented at the European Congress on Obesity 2026 in Istanbul, and what each finding means for patients on Ozempic, Wegovy, Mounjaro, and Zepbound right now. He covers the new higher-dose Wegovy data (7.2 mg), the maintenance dosing trial Zepbound patie...

There are now two FDA-approved GLP-1 pills for weight loss, and they are not the same drug. Dr. Clete Barrick (board-certified in internal medicine and obesity medicine) breaks down the side-by-side: the chemistry, the dosing rules, the weight loss data, the side effects, the cost, and which patient profile fits each pill. What you'll learn: - Why Foundayo (orforglipron) and oral Wegovy (sema...

A new study in Nature Health used AI to scan over 400,000 Reddit posts from 67,000 GLP-1 users and uncovered side effects that aren't on the label. Fox News, CNN, and Medscape ran the same headline: "hidden side effects doctors are missing." Dr. Clete Barrick, board-certified in internal medicine and obesity medicine, prescribes these medications every day and takes tirzepatide hims...

Semaglutide or tirzepatide? Ozempic or Mounjaro? It's the most asked question in GLP-1 medicine, and Dr. Clete Barrick has prescribed both to over 5,000 patients. In this episode, he covers the real differences between single and dual agonist medications, the head-to-head SURMOUNT-5 trial results, side effect profiles (including the birth control interaction most providers miss), who actually...

Your body already makes GLP-1 every time you eat. The problem? Natural GLP-1 lasts about two minutes before an enzyme destroys it. Semaglutide and tirzepatide are engineered to do the same job, just louder and longer. Dr. Clete Barrick breaks down how these medications work at three job sites: your pancreas, your stomach, and (most importantly) your brain. He explains the difference between homeos...

Dr. Clete Barrick is dual board-certified in internal medicine and obesity medicine, has treated thousands of GLP-1 patients going on five years, and has personally lost over 80 pounds on tirzepatide. In this premiere episode of Straight Shot, he tells the full story: how a Navy physician couldn't outrun his own biology, what changed when the food noise went quiet, and why he built this show....