Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN
Solving the Puzzle with Dr. Datis Kharrazian
Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases. His goal is to help teach you effective models for so-called “mystery” symptoms and conditions...
Author
Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN
Category
Podcast website
Latest episode
Jul 7, 2026
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Episodes
Episode 19: The vagus nerve and gut health 11.11.2021 56:58
In this video, Dr. Kharrazian explains how the vagus nerve affects digestion and other aspects of gut health, factors that can compromise vagus function, and the best ways to strengthen your vagus nerve . Not all vagal exercises are alike and you want to use the most effective ones. Dr. Kharrazian has worked with many patients over the years whose gut health was significantly compromised from poor...
Episode 18: How hypothyroidism causes depression and anxiety 27.10.2021 18:36
If you struggle with chronic depression, anxiety, or other mood disorders, you may suffer from undiagnosed hypothyroidism. A thyroid hormone deficiency can cause multiple brain-based symptoms. This is because thyroid hormones play an important role in the function of many areas of the brain, including neuron health, brain immune cells called neuroglia, and the blood-brain barrier. If you have a ch...
Episode 17: The best (and worst) supplements for Hashimoto's hypothyroidism 20.10.2021 14:45
Not all thyroid supplements are equally effective – in fact, some can actually make your hypothyroid symptoms worse. You might have come across the mistaken belief that hypothyroidism is caused by a nutritional deficiency of iodine, tyrosine, or thyroid glandulars. This is an outdated theory from the 1950s and ‘60s that unfortunately still persists today. In actuality, iodine and tyrosine are...
Episode 16: The best diet for Hashimoto's hypothyroidism 13.10.2021 21:46
It’s an incredibly common question among hypothyroid patients: what’s the best diet for hypothyroidism? While specific diet plans can certainly make a profound impact, for the best results you have to tailor your diet to your individual needs. Outdated myths persist when it comes to the best diets for hypothyroidism, and we should tackle some of those before moving ahead into the...
Episode 15: Environmental chemicals and hypothyroidism 06.10.2021 18:04
You might not realize just how many chemicals you encounter on a day-to-day basis. Each of us is routinely exposed to thousands of different chemicals – many of which can impact your thyroid health. Some of these chemicals are cleared out of the body through liver “biotransformation.” Commonly called detoxification, this is the process through which liver enzymes convert chemicals into water-solub...
Episode 14: How hypothyroidism affects gut health 29.09.2021 19:09
If you’ve been diagnosed with hypothyroidism, you should know low thyroid function can impact your gut health. This is why it’s important to properly manage the underlying mechanisms of your hypothyroidism. An intimate relationship exists between your gastrointestinal tract and your thyroid, with each affecting the other. The health of the stomach, gut microbiome, pancreas, liver, gallbladder, and...
Episode 13: The #1 rule when working on gut health 15.09.2021 1:00:32
If you're like 3/4 of Americans, you suffer from IBS, diarrhea, acid reflux, constipation, abdominal pain, leaky gut, SIBO, bloating and gas, and so on. In this podcast Dr. Kharrazian explains the number-one rule he follows when working with any gut health patient: Start at the top and work your way down. If you are trying to improve your microbiome but your gallbladder is congested, you likely wo...
Episode 12: "Leaky brain" in brain fog, fatigue, and depression 08.09.2021 1:01:01
You may have heard of leaky gut but did you know you can get leaky brain too? The most common symptoms are brain fog and slower mental speed, but an intestinal blood-brain barrier plays a role in numerous brain disorders. Learn more in this episode and from great viewer questions. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian . Hosted on Acast. See acast....
Episode 11: Mold toxicity — a silent factor in chronic illness 01.09.2021 58:29
Mold toxicity is a silent factor a lot of people don’t consider when rooting out causes for chronic health issues. Because most of its signs and symptoms are invisible to everyone else, it often goes unsuspected until symptoms become disabling. Many factors can play a role in mold toxicity, from water damage in your home, school, or workplace, to indoor humidity levels, genetic susceptibility, and...
Episode 10: GI symptoms from low stomach acid and gallbladder sludge 25.08.2021 56:34
Low stomach acid and gallbladders sludge are very common gut issues in Americans. Low stomach acid can lead to symptoms such as acid reflux, heartburn, indigestion, belching and bloating, and discomfort after eating meats and proteins. Gallbladder sludge can lead to belching and bloating, burping up fish oil capsules, and discomfort after eating fats. Both of these disorders lead to problems throu...
Episode 9: Histamine and Mast Cell Activation Syndrome (MCAS) 18.08.2021 1:01:10
In this episode, Dr. Kharrazian goes over the primary mechanisms of histamine intolerance and mast cell activation syndrome (MCAS). But first, make sure you even have these conditions as these diagnoses are being tossed around a little too casually these days. While the low-histamine diet may reduce symptoms, it does not necessarily address the underlying causes and it deprives you of cultured foo...
Episode 8: Causes and solutions for chronic bloating 11.08.2021 1:02:23
Chronic bloating and abdominal distention are common gut health complaints. In this podcast, Dr. Kharrazian covers the primary causes of bloating and how to start implementing solutions. Multiple things can cause bloating, with the underlying mechanisms depending on the individual. You must work north-to-south in the GI tract to identify where your issues lie. Brain-based mechanisms, chewing, stom...
Episode 7: How hypothyroidism affects your appearance 04.08.2021 28:50
Hypothyroidism, or low thyroid function, impacts your skin, hair, nails, joints, body inflammation, systemic inflammation—all of which affect your physical appearance. The most common cause of hypothyroidism is an autoimmune disease called Hashimoto’s, a disorder that causes the immune system to attack and destroy the thyroid gland. It is an incurable condition but can typically be driven into rem...
Episode 6: How hypothyroidism affects the body and causes a variety of symptoms 28.07.2021 33:33
What happens to your health when your thyroid hormones are low? In this episode, Dr. Kharrazian talks about the various conditions that can cause low thyroid hormones, including Hashimoto’s disease, improper hormone conversion, and incorrect hormone replacement. He then goes through the impact of thyroid hormone deficiency on different systems in the body and how that can affect symptoms and healt...
Episode 5: Gluten and Chronic Health Conditions 02.07.2021 1:04:08
Gluten is a much more complex topic than most people realize. First of all, most gluten sensitivity testing is extremely limited as it only tests alpha gliadin. The truth is, people can react to many different portions of wheat, including the lectins in wheat agglutinin, and various other gliadans besides alpha gliadin. Unless you screen for an immune reactivity to all of these compounds using ELI...
Episode 4: Understanding PANS and PANDAS 02.07.2021 1:05:19
PANDAS and PANS are autoimmune brain disorders that affect children in the aftermath of a strep infection or other infections. Symptoms include sensory, emotional, or movement disorders. These conditions are often misunderstood, misdiagnosed, and inappropriately treated. In this talk, I explain what causes PANDAS and PANS, lab testing, management strategies, and expected challenges in working with...
Episode 3: How Gluten Affects the Brain 02.07.2021 1:03:55
Do you suffer from fatigue, brain fog, depression, cognitive issues, mood or psychiatric issues, or memory loss? A gluten sensitivity manifests neurologically in 2/3 of people — most people do not have gut symptoms in response to gluten. Researchers call gluten sensitivity a neurological disease. Yet gluten sensitivity is significantly under diagnosed due to incomplete testing. If you ha...
Episode 2: The Top 10 Triggers of Autoimmune Disease and Flare Ups 02.07.2021 1:02:38
Many people think their autoimmune management depends on diet. While diet plays a key role, it does not go the full distance for everyone. The autoimmune journey involves finding your underlying mechanisms and triggers. They are different for everyone...and they are not always obvious. First, you have to know what the possible triggers are. Research has identified quite a few. Then you have to kno...
Episode 1: 10 Reasons Autoimmune Patients Don't Get Better 01.07.2021 59:16
It takes the average autoimmune patient 10 years and visiting 20 doctors before receiving an autoimmune diagnosis. There is very little medical training on autoimmunity and the disease must be quite advanced before doctors can intervene. In the meantime, patients suffer not knowing what to do. As a result, you must take charge of your own health and education when it comes to autoimmunity. Ample r...
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