Metabolism Made Easy

This podcast covers the regulation of HMG CoA Reductase by hormones, covalent modification, cytoplasmic cholesterol, and statins.

This podcast defines metabolism and its two distinct components: anabolism and catabolism. The major compartments involved in both are also covered. If you like this podcast, feel free to donate to the podcast.

This podcast covers the distinct uses of glucose, fatty acids, and amino acids and their unique roles in metabolism.

This podcast covers the key role of the liver and adipose tissue in providing energy sources to the plasma during fasting. The liver is the provider of glucose and fatty acids, while adipose tissue provides fatty acids to the bloodstream.

While following a ketogenic diet, maintenance of plasma glucose is essential for several tissues. The amino acids derived from dietary proteins will provide the carbon skeletons for glucose synthesis by the liver, while the triacylglycerols from dietary fat will provide the energy for various tissues through Beta-oxidation of fatty acids.

This podcast covers the production of cAMP by activation of either the beta-adrenergic receptor or the glucagon receptor as well as the activation of the alpha1-adrenergic by epinephrine to produce IP3, DG and calcium.

This podcast covers the 3 stages of catabolism from the intestinal lumen to inside the cell. The energy output is mostly produced in the mitochondrial catabolic pathways. Similar content is available at: https://medbiochem.org/

This podcast covers the major pathways for catabolism of glucose and fatty acids, including the ATP output from their complete degradation to CO2. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the target enzymes of NSAIDS and cortisol and their respective effects on inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the effect of phophorylstion/dephosphorylation by protein kinases and phosphatases on enzyme activity. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the activation of the Insulin receptor resulting in activation of an intracellular protein phosphatase. The deposphorylation of eight enzymes is also covered. This dephosphorylation results in profound effects on carbohydrate, lipid and protein metabolism. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the key tissue effects of insulin in the well-fed state including its effects on liver, muscle and adipose tissue. Also covered are the effects of insulin on regulating key enzymes involved in carbohydrate and lipid metabolism. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the digestion, reassembly, absorption and storage of dietary Triacylglycerol including the role of pancreatic lipase and lipoprotein lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the liver output of glucose during fasting and its regulation by glucagon. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the phosphorylation of enzymes by protein kinases that modify specific hydroxyl residues in enzymes. This content may be useful to premedical and medical students. Similar biochemistry content is available at: MEDBIOCHEM.ORG

This podcast describes the specific mechanism by which statins reduce plasma cholesterol. The reduction of cholesterol synthesis by statins in effect, will result in the upregulation of the LDL receptor and increased uptake of LDL from plasma. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the specific metabolic effects of insulin on liver, muscle and adipose tissue. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the key components of the adenylate cyclase system including receptor activation, G-protein involved, activation of adenylate cyclase , production of cAMP, activation of PKA and termination of the actions of cAMP . Also included is a historical perspective of the discovery of G-proteins the adeylate cyclase system.

This podcast describes the activation of the a phosphoprotein phosphatase by insulin. Also check out the podcast below for insulin's effects on specific enzymes: https://anchor.fm/a-j-ghalayini/episodes/Insulin-and-Enzyme-Dephosphorylation-e1mb74a

This podcast covers key enzymes in carbohydrate and lipid metabolism the are phosphorylated by either PKA or AMP kinase and the outcome of phosphorylation on enzyme activity. Also check out the podcast on Adenylate Cyclase below: https://anchor.fm/a-j-ghalayini/episodes/Adenylate-Cyclase-7-Key-Features-e1nb35t

This podcast describes the effect of cortisol on eicosanoid biosynthesis and its resulting anti-inflammatory effects. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the outcome of dephosphorylation of key enzymes trigerred by Insulin binding to its receptor and resulting in changes of both carbohydrate and lipid metabolism. Also check out my Insulin playlist on YouTube below for additional videos: INSULIN: https://www.youtube.com/playlist?list=PLXy2KYiCd9rlWs3TxwuMk26ncmzva3PM3. This biochemistry content may be useful to premedical and...

This podcast covers in the detail the actions of phospholipase C starting with receptor activation, activation of Gq, production of second messengers and activation of PKC. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG Biochemistry by Metabolism Made Easy playlist on YouTube: https://www.youtube.com/playlist?list=PLXy2KY...

This podcast covers the only 2 enzymes that require Vitamin B12 . This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the 4 enzymes requiring thiamine as a coenzyme. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG