Metabolism Made Easy

This podcast covers the regulation of pyruvate kinase allosterically and by hormone-dependent (insulin & glucagon) covalent modification.

This podcast covers the metabolic changes in various organs and key organ uses of the available nutrients in the bloodstream.

With the exception of ketone bodies, the brain is entirely dependent on glucose as an energy source under most circumstances. Glucose is oxidized all the way to CO2 by the brain, producing up to 38 ATPs. This catabolism is dependent on oxygen, which is used to convert the energy in NADH and FADH2 to ATP through the Electron Transport Chain and Oxidative Phosphorylation.

This podcast covers the digestion of the major dietary fat, triacylglycerol, including digestion uptake into intestinal mucosa, delivery through the bloodstream, uptake and storage of fatty acids from chylomicrons in the bloodstream.

This podcast describes the transport of ammonia produced in peripheral tissues by incorporating it into glutamine through glutamine synthase. Glutamine is transported in the bloodstream to either the liver or kidney for further metabolism.

This podcast provides an overview of metabolic changes associated with fasting, including key metabolic changes in the liver and adipose tissue. The liver will increase its output of glucose and ketone bodies, while adipose tissue will provide fatty acids to the bloodstream for other peripheral tissues to use during fasting.

This podcast summarizes the key biochemical components of metabolism, including: 1. definition; 2. cellular location; 3. the major catabolic pathways; 4. the 3 stages of catabolism; 5. the 12 major metabolic uses of glucose, fatty acids and amino acids; 6. the energy output of catabolism of glucose, fatty acids, and ketone bodies.

This podcast covers 5 distinct enzyme regulatory mechanisms and their effects on enzyme structure and activity.

This podcast covers the function and the location of the urea cycle, including some key features and the sequence of the enzymes as well as their location.

This podcast covers the role of transaminases the initial step in the degradation of amino acids. This includes the role of glutamate dehydrogenase in producing ammonia. The ammonia and aspartate produced are then able to enter the urea cycle in the liver.

This podcast covers the role of adipocytes in energy storage and their role in initiating lypolysis of stored triacylglycerols to provide various tissues with fatty acids as a energy source. The role of fatty acid Beta-oxidation in providing energy from both dietary or stored triacylglycerols is also covered.

This podcast covers the details of the conversion of lactate produced during exercise to glucose in the liver and ultimately releasing it to the bloodstream.

This pocast covers the regulation of the Rate-limiting enzyme in fatty acid synthesis, Acetyl CoA Carboxylase allosterically, and by covalent modification.

This podcast covers the regulation of HMG CoA Reductase by hormones, covalent modification, cytoplasmic cholesterol, and statins.

This podcast defines metabolism and its two distinct components: anabolism and catabolism. The major compartments involved in both are also covered. If you like this podcast, feel free to donate to the podcast.

This podcast covers the distinct uses of glucose, fatty acids, and amino acids and their unique roles in metabolism.

This podcast covers the key role of the liver and adipose tissue in providing energy sources to the plasma during fasting. The liver is the provider of glucose and fatty acids, while adipose tissue provides fatty acids to the bloodstream.

While following a ketogenic diet, maintenance of plasma glucose is essential for several tissues. The amino acids derived from dietary proteins will provide the carbon skeletons for glucose synthesis by the liver, while the triacylglycerols from dietary fat will provide the energy for various tissues through Beta-oxidation of fatty acids.

This podcast covers the production of cAMP by activation of either the beta-adrenergic receptor or the glucagon receptor as well as the activation of the alpha1-adrenergic by epinephrine to produce IP3, DG and calcium.

This podcast covers the 3 stages of catabolism from the intestinal lumen to inside the cell. The energy output is mostly produced in the mitochondrial catabolic pathways. Similar content is available at: https://medbiochem.org/

This podcast covers the major pathways for catabolism of glucose and fatty acids, including the ATP output from their complete degradation to CO2. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the target enzymes of NSAIDS and cortisol and their respective effects on inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the effect of phophorylstion/dephosphorylation by protein kinases and phosphatases on enzyme activity. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the activation of the Insulin receptor resulting in activation of an intracellular protein phosphatase. The deposphorylation of eight enzymes is also covered. This dephosphorylation results in profound effects on carbohydrate, lipid and protein metabolism. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the key tissue effects of insulin in the well-fed state including its effects on liver, muscle and adipose tissue. Also covered are the effects of insulin on regulating key enzymes involved in carbohydrate and lipid metabolism. Similar content is available at: MEDBIOCHEM.ORG