Chris Masterjohn, PhD
Mastering Nutrition
Welcome to the Mastering Nutrition podcast. Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person's metabolism by finding their own unique unlocks. He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University...
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Chris Masterjohn, PhD
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Podcast website
Latest episode
Dec 15, 2025
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Episodes
How I Lost My COVID Weight 19.11.2021 1:15:35
Here's the written article with pictures and data: https://chrismasterjohnphd.com/blog/2021/11/18/masterjohn-goes-fit2fat2fit-but-by-accident In case I get deplatformed, please follow me on Telegram, join my Occasional Newsletter, and join the Masterpass Free Forum: You can find me on Telegram here: https://t.me/chrismasterjohnphd Occasional Newsletter: https://chrismasterjohnphd.com/newsletter Fr...
Please Attend the World Wide Rally for Freedom TOMORROW! 19.11.2021 1:45
https://worldwidedemonstration.com For NYC, my local anti-mandate list at https://chrismasterjohnphd.com/mandate In case I get deplatformed, please follow me on Telegram, join my Occasional Newsletter, and join the Masterpass Free Forum: You can find me on Telegram here: https://t.me/chrismasterjohnphd Occasional Newsletter: https://chrismasterjohnphd.com/newsletter Free Forum: https://chrismaster...
FDA Wants Until 2076 to Release Pfizer Data (?!) 19.11.2021 11:08
Source: https://www.reuters.com/legal/government/wait-what-fda-wants-55-years-process-foia-request-over-vaccine-data-2021-11-18/ In case I get deplatformed, please follow me on Telegram, join my Occasional Newsletter, and join the Masterpass Free Forum: You can find me on Telegram here: https://t.me/chrismasterjohnphd Occasional Newsletter: https://chrismasterjohnphd.com/newsletter Free Forum: htt...
New CDC Natural Immunity Study (Long Version) 03.11.2021 1:00:29
https://chrismasterjohnphd.com/cdc for the full article. https://chrismasterjohnphd.com/cdcuncensored for the slide deck. https://chrismasterjonphd.com/newsletter to stay in touch. https://chrismasterjohnphd.com/support or https://chrismasterjohnphd.com/donate to support this work. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
The New CDC Natural Immunity Study (Short Version) 03.11.2021 4:00
https://chrismasterjohnphd.com/cdc for the full article. https://chrismasterjohnphd.com/cdcuncensored for the slide deck. https://chrismasterjonphd.com/newsletter to stay in touch. https://chrismasterjohnphd.com/support or https://chrismasterjohnphd.com/donate to support this work. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
Natural Immunity 29.10.2021 1:36:44
Please consider supporting my work at chrismasterjohnphd.com/support or chrismasterjohnphd.com/donate. This is the written article being discussed: https://chrismasterjohnphd.com/naturalimmunity Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome .
If glutathione whitens your skin, is that good or bad? | Masterjohn Q&A Files #294 07.10.2021 4:15
Short Answer: Measure this against whether it increases your likelihood of burning. If it does, it's probably a bad thing, but if it doesn't, or if it lowers your risk of burning, that's a good thing. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider s...
Vitamin D supplements, testing, and interactions with the vaccine. | Masterjohn Q&A Files #293 06.10.2021 6:58
Short Answer: Vaccination shouldn't change the vitamin D requirement. Quarterly testing makes sense for someone who has never tested before or who wants to make sure they stay in range during COVID, but generally testing yearly around the mid-point of seasonality for you, once you know your variation, is plenty. Watch the video or listen to the podcast with the links below. You can obtain a full t...
BH4 vs tyrosine for low neurotransmitters and a high phenylalanine-to-tyrosine ratio. | Masterjohn Q&A Files #292 05.10.2021 19:12
Short Answer: BH4 is expensive and requires very high doses, so if the problem is modest it can much more easily be solved by taking tyrosine. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consider supporting my work by making a purchase using these links a...
Does TMG have to be taken in the fasting state? | Masterjohn Q&A Files #291 04.10.2021 4:00
Short Answer: While the body will tend to use TMG for methylation in the fasting state, it is normally found in food, so you should be able to absorb it with meals and hold on to it for later use, much as we do with folate. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.co...
Is urinary mycotoxin testing useful for indoor mold exposure? | Masterjohn Q&A Files #290 01.10.2021 8:04
Short Answer: When I had a serious case of indoor mold-induced illness, I tested my urine and my apartment dust for mycotoxins. Both were high, but the classes of toxins were totally different between the two, making me think the mycotoxins in my urine came from food rather than my apartment. Symptoms going away when outside of the apartment was a far more useful clue, so I think you should consid...
Ferritin sky-high without hemochromatosis? | Masterjohn Q&A Files #289 30.09.2021 11:35
Short Answer: Even if genetics and other bloodwork don't look like hemochromatosis, sky-high ferritin justifies trying to lower it with blood donation or phlebotomy if inflammation markers are low. If this doesn't work, oxidative stress should be investigated. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Master...
Will the booster shot be worth it? | Masterjohn Q&A Files #288 29.09.2021 14:36
Short Answer: If optimizing for efficacy, the booster shot will likely be worth it for Pfizer, whereas other vaccines don't have clear evidence of declining efficacy yet. If optimizing for safety, one should be skeptical of the booster since a 3-dose regiment hasn't been tested in clinical trials. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of th...
How to use carbs and glycine for sleep. | Masterjohn Q&A Files #287 28.09.2021 10:52
Short Answer: To get adequate raw material for melatonin synthesis in the brain, carbs can come any time of day and are best if high-glycemic. To suppress brain histamine levels, carbs in the evening, with low protein and relatively low fat, is best. From among protein, collagen is best at night for the glycine. Watch the video or listen to the podcast with the links below. You can obtain a full t...
What are the downsides to taking prescription calcitriol for bones? | Masterjohn Q&A Files #286 27.09.2021 5:41
Short Answer: It requires more frequent dosing and has some risk of hypercalcemia, and it would be best to make sure you have adequate D and magnesium and aren't overdoing anything that could deplete D, such as other fat-soluble vitamins, first. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https:/...
NEW! Version 7 of the COVID Guide! 26.09.2021 7:43
Newly updated September 25, 2021, and now in Version 7: https://chris-masterjohn-phd.myshopify.com/products/the-food-and-supplement-guide-for-the-coronavirus This guide provides my recommendations for nutritional and herbal defense against COVID. This version covers 41 randomized controlled trials, which are the gold standard of evidence, as well as many other studies providing context for interpr...
Does quinolinate sometimes indicate niacin or inflammation instead of B6? | Masterjohn Q&A Files #285 24.09.2021 11:33
Short Answer: B6 cannot be ruled out, though inflammation and estrogen could also be involved. While it is possibly a regulated means of increasing excitatory effects of quinolinate, it makes sense to assume it may respond to B6. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohn...
Why would 5,000 IU vitamin D cause tooth sensitivity? | Masterjohn Q&A Files #284 23.09.2021 6:53
Short Answer: While it is unclear, it could relate to vitamin K depletion, hypercalcemia, or compensation in acid-base balance. First and foremost, use the full testing algorithm in Testing Nutritional Status: The Ultimate Cheat Sheet (available at https://chrismasterjohnphd.com/cheatsheet ) rather than just testing 25(OH)D to determine deficiency. Watch the video or listen to the podcast with the...
What's the best and most affordable diet for a hungry teenage boy? | Masterjohn Q&A Files #283 22.09.2021 14:48
Short Answer: A half a gram to a gram of protein per pound of bodyweight, no more than 20-40 grams of that from protein powder, and whole foods supplying the targets for vitamins and minerals, erring on the side of overshooting them. Lentils and other legumes as primary carb foods and supply a portion of protein, and adjusting quality of meat to what you can afford, can help with budgeting. This v...
Why would MCV be elevated if MMA and FIGlu are normal? | Masterjohn Q&A Files #282 21.09.2021 6:49
Short Answer: If the cause is nutritional, FIGlu cannot rule out folate deficiency as a cause because it reflects tetrahydrofolate rather than methylene-THF. So, increasing the dose of folate or switching from methylfolate to folinic acid could be tried. Otherwise the most likely nutritional solution would be copper. Watch the video or listen to the podcast with the links below. You can obtain a...
How to further explore slightly high coronary calcium and Lp(a) and borderline high LDL-P? | Masterjohn Q&A Files #281 20.09.2021 13:18
Short answer: If inflammatory markers are low and Lp(a) is proportionally more elevated than LDL-P, then blood lipids probably account for part of the calcification, while factors impacting LDL oxidation come next and those impacting calcification directly come after that. For the latter two, the oxidative stress and calcium sections of the Cheat Sheet should be consulted. Watch the video or liste...
Is blackstrap molasses toxic because of AGEs? | Masterjohn Q&A Files #280 17.09.2021 7:42
Short answer: The science behind dietary AGEs being bad for us is very poor-quality. While food that is treated to excessively high heat, such as fried food, should not be the major portion of our diet, dietary tables of AGEs in foods are not accurate and dietary AGEs are probably not a major source of AGEs within our bodies. Blackstrap molasses should be seen as a sweetener that is better than re...
Why can the sodium-potassium pump work backwards? | Masterjohn Q&A Files #279 16.09.2021 25:50
Short answer: The second law of thermodynamics means that concentrations of specific chemicals or positive or negative charges will always "want" to disperse and randomly mix in their environment, making concentrations of ions such as sodium or potassium a form of potential energy. While the pump normally uses energy from ATP to invest into creating those concentrations, if ATP levels are low and...
If What can I take to improve my memory? | Masterjohn Q&A Files #278 15.09.2021 8:08
Short answer: Alpha-GPC, ginkgo biloba, lion's mane, and a comprehensive analysis of your nutrient status as outlined in Testing Nutritional Status: The Ultimate Cheat Sheet to see if anything is missing. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please consid...
If you have high ferritin, are there any downsides to blood donation? | Masterjohn Q&A Files #277 14.09.2021 5:34
Short answer: Apart from well known acute risks such as fainting, hypoglycemia, or dehydration from a blood donation, there isn't anything to worry about except making sure you don't become deficient in iron. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a Please co...
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