Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

Watch the FULL podcast here: https://youtu.be/yZDzsfNjG_M Could your brain host healthy bacteria? This clip explores how parts once taught as sterile, such as breast milk, the bladder, and the brain, contain beneficial microbes, and what they might be doing. We touch on gut and brain communication through the vagus nerve, the idea of dysbiosis versus infection, and why modern findings ask for humi...

A quick note before we begin This year, I’m doing something I’ve wanted to do for a long time. I want to start this year by sharing something a little different. After four years of Live Well Be Well, I’m introducing regular solo episodes. It’s taken me a long time to get here. Not because I didn’t have things to say, but because it’s taken a lot of belief in myself to sit here and share my own th...

Watch the FULL podcast here: https://youtu.be/QeNdkCVYquU Can nutrition and supplements meaningfully lower dementia risk or mainly boost day-to-day focus? They matter within a broader Three S model that links stimulus, supply, and support for brain adaptation. This clip explores why cognitive challenge is the primary stimulus, how supply depends on blood flow, oxygen, and fuel, and how support inc...

Are GLP-1 weight loss drugs a smart first step for obesity? They’re helping many people lose significant weight, yet concerns remain about side effects, muscle loss, cost, and regaining weight after stopping. This clip explores the promise and limits of GLP-1s, the call for long term data, and the need to pair medication with nutrition education, counseling, and strength training. It also consider...

In this episode of Live Well Be Well, I’m joined by Dr. William Li, physician scientist, bestselling author, and president of the Angiogenesis Foundation. William is one of the world’s leading voices on food as medicine, and together we explore how nutrition, immunity, and brain health are deeply connected, often in ways we underestimate. In this conversation, Dr. William Li shares how the body’s...

Watch the FULL podcast here: https://youtu.be/QeNdkCVYquU Does having APOE4 mean Alzheimer’s is inevitable? It doesn’t, and I explain how genes interact with lifestyle and environment to shape risk. This clip explores early-onset familial mutations versus common late-onset cases, APOE4 as a risk multiplier, population data from some Indigenous groups, Nigerians, and Sicilians, key lifestyle factor...

Watch the FULL podcast here: https://youtu.be/ZXLWY5HcPXE In this conversation, I sit down with Andy Galpin to talk about sleep, and why so many of us are still struggling with it despite doing “all the right things”. We unpack why sleep is getting worse globally, even as awareness and spending on sleep continue to rise. Andy explains why focusing on sleep duration alone misses the bigger picture,...

What if the qualities you’ve been taught to override are actually the ones keeping you well? To round of 2025, I’m joined by world-leading thinkers including Simon Sinek, Dr. Rick Doblin, Robin Sharma, Professor Nicolau, and Dr. Sarah McKay to explore what truly shapes our wellbeing when the noise fades and the signal becomes clearer. This episode weaves together some of the most powerful moments...

Watch the FULL podcast here: https://youtu.be/7kfykswH6Io This clip explores how to identify zone two intensity without relying on a wearable. I discuss the link between breathing rate, conversation ability and the underlying metabolic changes that define this training zone. We take a closer look at why many people unintentionally drift into higher intensities, suppress fat oxidation and struggle...

👉 Practical beats perfect. Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/ 👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahma...

Watch the FULL podcast here: https://youtu.be/IIenBH9xAEk This segment explores how stress affects the body and why recovery matters just as much as the stress itself. The discussion makes clear that stress is normal, but what truly impacts health is how quickly we return to homeostasis once the moment has passed. Here, we examine the difference between ongoing strain and healthy regulation, the r...

👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/ During this special holiday, I wanted to pause for a moment. Not to teach or analyse, but simply to say thank you. This is a short and heartfelt message from me to you. A moment to reflect on the year we’ve shared together, the community we’ve built, and...

Watch the FULL podcast here: https://youtu.be/qHFymGgsYyE Want to reduce everyday toxins at home without overhauling your life? This conversation shares practical swaps for cleaners, pest control, and plastics that lower exposure while keeping things simple. This clip explores why antibacterial cleaners and strong fragrances aren’t necessary, how a single non-toxic concentrate can replace multiple...

Watch the FULL podcast here: https://youtu.be/ZXLWY5HcPXE Finding it hard to stay healthy in your 40s while raising kids? This clip explores choosing one non-negotiable habit to protect your time, the midlife mental load, and why what worked in your 20s may not now. This segment examines childbirth’s lasting impacts on sleep, mood, and body composition, plus staged sleep strategies for conception,...

👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/ What if cognitive decline is not inevitable, but quietly shaped by how we live, think, and engage with the world each day? This week on Live Well Be Well, I’m joined once again by Dr Tommy Wood, neuroscientist, researcher, and author of The Stimulated Min...

Watch the FULL podcast here: https://youtu.be/7kfykswH6Io Why is zone two training so important for mitochondrial health? It’s linked with improvements in fat oxidation and lactate clearance, which are used as surrogates of mitochondrial function in sports science. This clip explores how different exercise intensities drive distinct metabolic responses, why athletes are useful models for understan...

Watch the FULL podcast here: https://youtu.be/XXwgXDeOYJI Are seed oils the real issue, or are we missing the bigger picture? We examine the weak evidence for harm, the role of rancidity and context, and why blanket bans miss the mark. This clip explores public health messaging, the push for simple slogans, and claims about beef tallow versus seed oils. We also touch on how activism, diet context,...

👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/ Longevity is everywhere right now, but has it become a trend instead of a truth? In a world overflowing with health hacks, supplements, and promises of a longer life, it has never been harder to know what actually works. Beneath the noise, there is a clea...

Watch the FULL podcast here: https://youtu.be/7kfykswH6Io Are you getting the balance between Zone 2 and HIIT right? I’m exploring how an 80/20 split by sessions, with most training at lower intensity and select high-intensity work, supports results without burning you out. This clip explores why all-HIIT programs often feel unsustainable and can lead to fatigue or injuries, what 80/20 really mean...

Watch the FULL podcast here: https://youtu.be/IIenBH9xAEk Are wearables helping you understand your health or making you feel more stressed? This clip explores how our relationship with daily health scores can shape how we feel and why long term trends matter more than single-day data. This discussion focuses on the mindset behind using wearables, why subjective sleep quality often predicts wellbe...

👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/ What if everything you’ve believed about “fast” and “slow” metabolism has quietly been steering you off course? And what if the real barriers to sustainable fat loss have less to do with willpower, and far more to do with how your body protects you when i...

Watch the FULL podcast here: https://youtu.be/HQepDqbCIyI How can changes in fascia and daily movement influence the face and overall wellbeing? This clip explores a four-year journey shown through photos, highlighting shifts in facial alignment, skin tone and emotional expression as he adjusted lifestyle habits. This discussion focuses on reducing everyday chemical exposure, addressing past injur...

Watch the FULL podcast here: https://youtu.be/7kfykswH6Io This clip explores why VO2 max, despite being a long-standing marker of fitness, does not capture the full picture of our metabolic and longevity potential. We take a closer look at how oxygen is actually used at the cellular level and why mitochondrial function is emerging as the next frontier in understanding performance and healthy agein...

👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/ Here's the thing about stress that nobody tells you: it's not actually happening to you. You're actively participating in creating it. That sounds provocative, maybe even annoying if you're genuinely stressed right now. But stay with me, because what Dr....

Watch the FULL podcast here: https://youtu.be/KO_kNTtWahU Do you want to feel more alive without having to earn it by ticking everything off first? I’m exploring how the natural drive to improve is healthy, but using it to reach a standard so you can finally relax keeps you gripping for certainty you can’t get. This clip explores the relief of seeing that the future can’t be made certain, why “get...