JAMA Clinical Reviews

Deaths during pregnancy and in the early postpartum period have increased in the US over the past several years, and approximately 80% of these deaths are considered preventable. JAMA Senior Editor Kristin L. Walter, MD, MS, speaks with Sadiya S. Khan, MD, MSc, from Northwestern University about the importance of monitoring and improving cardiovascular health during the postpartum period. Related...

Obesity affects approximately 42% of adults in the US. Multiple strategies are available to treat obesity, including behavior therapies, GLP-1 receptor agonists, and bariatric surgery. Therapies vary in effectiveness and risks. JAMA Deputy Editor Mary McGrae McDermott, MD, discusses evidence-based obesity treatment with Melanie Jay, MD, MS, New York University Grossman School of Medicine. Related...

Critical bleeding is associated with a high mortality rate in patients with trauma. JAMA Associate Editor Christopher W. Seymour, MD, MSc, discuses the results of the CRYOSTAT-2 trial with Nicola Curry, MD, Oxford University Hospitals, and Ross Davenport, PhD, Centre for Trauma Sciences, UK. Related Content: Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

In July 2023, the US Food and Drug Administration (FDA) approved the first oral contraceptive pill (Opill) that will be available without a prescription. JAMA Senior Editor Kristin Walter, MD, MS, spoke with JAMA Associate Editor Melissa A. Simon, MD, MPH, about the use, effectiveness, and potential side effects of Opill. Related Content: Over-the-Counter Progestin-Only Oral Contraceptives

Interview with John M. Ruiz, PhD, USPSTF member and coauthor of Screening and Preventive Interventions for Oral Health in Children and Adolescents Aged 5 to 17 Years, and Screening and Preventive Interventions for Oral Health in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening, Refe...

Approximately 5% of all primary care visits are related to knee pain. Osteoarthritis (OA), patellofemoral pain syndrome, and meniscal tears are among the most common causes of knee pain. JAMA Senior Editor Karen Lasser, MD, MPH, speaks with David Hunter, MD, PhD, from the University of Sydney, about common causes and first-line treatment of knee pain. Related Content: Evaluation and Treatment of K...

Hyperthyroidism affects 2.5% of adults worldwide and, if untreated, is associated with osteoporosis, heart rhythm abnormalities, heart failure, and increased mortality. JAMA Associate Editor Anne Cappola, MD, speaks with Elizabeth N. Pearce, MD, MSc, of Boston University, about the most common causes, symptoms, and first-line treatments for hyperthyroidism. Related Content: Hyperthyroidism

Preexposure prophylaxis (PrEP) and postexposure prophylaxis have recently gotten attention as ways to prevent sexually transmitted infections. JAMA Deputy Editor Preeti Malani, MD, MSJ, discusses postexposure prophylaxis using doxycycline (doxyPEP), with Kenneth H. Mayer, MD, professor of medicine and global health at Harvard and medical research director at Fenway Health in Boston. Related Conten...

Vasomotor symptoms are common during menopause and may have substantial negative effects on quality of life. JAMA Senior Editor Linda Brubaker, MD, MS, discusses nonhormonal therapies for menopausal vasomotor symptoms with Susan D. Reed, MD, MPH, MS, professor emeritus at the University of Washington and president and CEO of The North American Menopause Society. Related Content: Nonhormonal Therap...

Approximately 500 000 adults in the US have survived childhood cancer. JAMA Deputy Editor Mary McGrae McDermott, MD, speaks with Smita Bhatia, MD, MPH, University of Alabama, about common medical problems that occur in adults who have survived a childhood cancer and optimal approaches to medical care for these patients. Related Content: Clinical Care for People Who Survive Childhood Cancer

Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening for Hypertensive Disorders of Pregnancy: US Preventive Services Task Force Final Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Hypertensive Disorders of Pregnancy Screening for Hypertensive Disorders of Pregnancy Hypertension Screening in Pr...

Ulcerative colitis (UC) is a chronic inflammatory condition of the colon. Individuals with UC have a lower life expectancy and are at increased risk for colectomy and colorectal cancer. However, many new treatments are available. JAMA Senior Editor Karen E. Lasser, MD, MPH, speaks to Gilaad Kaplan, MD, MPH, University of Calgary, about the latest information related to this condition. Related Cont...

There are long-term cardiometabolic health risks for individuals with pregnancies complicated by gestational diabetes. JAMA Senior Editor Linda Brubaker, MD, MS, discusses these risks with Kartik K. Venkatesh, MD, PhD, high-risk pregnancy specialist at The Ohio State University. Related Content: Gestational Diabetes and Long-Term Cardiometabolic Health

Interview with John B. Wong, MD, USPSTF member and coauthor of Preexposure Prophylaxis to Prevent Acquisition of HIV: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Preexposure Prophylaxis for the Prevention of HIV New USPSTF Guidelines for HIV Preexposure Prophylaxis Preexposure Prophylaxis to Prev...

Each year approximately 100 000 people in the US are treated for cervical precancer, and about 4000 individuals die from cervical cancer. JAMA Senior Editor Melissa Simon, MD, MPH, and Rebecca B. Perkins, MD, MSc, Boston University School of Medicine, discuss the importance of HPV screening, genotyping and cytology testing, and HPV vaccination. Related Content: Cervical Cancer Screening

In this interview, dementia expert Gil D. Rabinovici, MD, discusses monoclonal antibodies that target beta-amyloid–-including a recent phase 3 trial of donanemab published in JAMA-–and reviews considerations for their use in patients with Alzheimer disease. Related Content: Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease Donanemab in Early Symptomatic Alzheimer Disease

Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Folic Acid Supplementation to Prevent Neural Tube Defects Folic Acid Supplementation to Prevent...

JAMA Associate Editor David L. Simel, MD, MHS, discusses the latest European Society of Intensive Care Medicine (ESICM) Guidelines on Acute Respiratory Distress Syndrome, which were released in June 2023, with Derek C. Angus, MD, MPH, University of Pittsburgh. Related Content: Caring for Patients With Acute Respiratory Distress Syndrome

Interview with Li Li, MD, PhD, MPH, USPSTF member and coauthor of Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Lipid Disorders in Children and Adolescents Screening for Lipid Disorders in Children and Adolescents Still "on th...

The incidence of Cushing syndrome due to endogenous overproduction of cortisol is 2 to 8 people per million annually. JAMA Deputy Editor Mary M. McDermott, MD, discusses diagnosis, management, and treatment of this condition with authors Martin Reincke, MD, from University of Munich, and Maria Fleseriu, MD, from Oregon Health and Science University. Related Content: Cushing Syndrome

The 2021 US maternal mortality rate is more than 10 times the rate of other high-income countries, according to a March 2023 CDC report. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, is joined by Monica McLemore, PhD, MPH, RN, University of Washington, Audra Meadows, MD, MPH, UC San Diego, and Joia Crear-Perry, MD, founder and president of the National Birth Equity Colla...

Interview with Michael Silverstein, MD, MPH, USPSTF chair and coauthor of Screening for Depression and Suicide Risk in Adults, and Screening for Anxiety Disorders in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Anxiety Screening Depression and Suicide Risk Screening Screening for Depressi...

JAMA Senior Editor Kristin Walter, MD, MS, speaks with Fernando Zampieri, MD, PhD, assistant professor in the Department of Critical Care Medicine at the University of Alberta in Alberta, Canada, about fluid therapy in critically ill adults with sepsis. Related Content: Fluid Therapy for Critically Ill Adults With Sepsis

Transgender and gender diverse persons may desire gender-affirming medical and surgical treatment that can mitigate psychologic distress and reduce suicide risk. JAMA Associate Editor David L. Simel, MD, MHS, speaks with Andrew M. Davis, MD, MPH, University of Chicago, and Tonia Poteat, PhD, PA-C, MPH, University of North Carolina, Chapel Hill, about the Standards of Care for the Health of Transge...

Cirrhosis affects approximately 2.2 million adults in the US, and the annual age-adjusted mortality of cirrhosis has increased from 2010 to 2021. JAMA Senior Editor Karen E. Lasser, MD, MPH, and Elliot B. Tapper, MD, from the University of Michigan, discuss the diagnostic workup and evidence-based therapies for cirrhosis. Related Content: Diagnosis and Management of Cirrhosis and Its Complications