JACC Author Interviews

JACC's February 17 issue gives readers a comprehensive focus issue on women's cardiovascular health, a long overlooked field of study. In this interview, JACC Associate Editor Makoto Mori, MD, joins resident Catherine M. Wagner, MD, MSc, to discuss her brief report on sex differences in tricuspid valve repair during mitral surgery, highlighting that women with moderate or severe tricuspid regurgit...

Early diagnosis in transthyretin cardiac amyloidosis (ATTR-CM) matters more than ever. Adith Arun talks with Dr. Ahmad Masri about key findings from the ATTRIBUTE-CM phase 3 trial on acoramidis, what recurrent event analyses reveal, and why delays in suspicion, diagnosis, or treatment can meaningfully impact outcomes. They also explore challenges in clinical pathways, updates in the therapeutic la...

JACC is pleased to publish this study from authors Nicole J. van Steijn, MD and Michiel M. Winter MD, PhD, featuring the results of integrating Apple Watch monitoring into a clinical workflow. In this video interview accompanying the article,  JACC: Associate Editor Xiaoxi Yao, PhD, MPH, MS  joins first author Nicole van Steijn, MD, to discuss how findings led to a fourfold increase in early atria...

This JACC Author Interview features  Karen Joynt Maddox, MD, MPH, and JACC Executive Associate Editor Mitsuaki Sawano, MD, discussing this paper published in the March 24 issue of JACC. The paper looks into cardiovascular care and outcomes among Medicare beneficiaries during the late phase of the COVID-19 pandemic (2021–2022). The research reveals persistent reductions in hospitalizations, increas...

In this episode of Behind the Science, Adith Arun, BS, speaks with Paul Lacaze, PhD, and Sultana Monira Hussain, PhD about their study in JACC's January 6 issue, examining loss of the Y chromosome (LOY) in older men and its association with cardiovascular disease. They discuss the study design, analytical approach, and key findings linking LOY to an increased risk of major adverse cardiovascular e...

In this episode of Behind the Science, Adith Arun and Dr. Neal K Lakdawala discuss the recent phase 2A trial of Danicamtiv in patients with dilated cardiomyopathy (DCM). They explore the study's design, patient cohorts, clinical implications, and the importance of genetic testing and patient-reported outcomes. The conversation also touches on the future of gene therapy in cardiomyopathy and ongoin...

In JACC's inaugural Behind the Science episode, Adith Arun, sits down with senior author Barry A. Borlaug, MD, to discuss his latest study published in JACC's December 16, 2025 issue, examining tricuspid regurgitation (TR) across the full spectrum of HFpEF. The study found that TR is common even in early HFpEF, with ventricular secondary TR (VSTR) representing the predominant pattern (≈26% vs. ≈8%...

Join JACC Associate Editor Emily Bucholz, MD, PhD, MPH, and author Rebecca Josowitz, MD, PhD as they discuss key findings from this JACC paper on placental malperfusion in congenital heart disease (CHD). The paper, published in JACC's November 11 issue, highlights future research directions, including identifying at-risk populations, developing imaging and molecular biomarkers, and exploring poten...

JACC continues its partnership with TCT 2025 in our latest interview, featuring JACC: Associate Editor Yousif Ahmad, MBBS, PhD, and author Shamir R. Mehta, MD, MSc. Listen here as they discuss this randomized, double-blind trial presented at TCT 2025 and published in JACC. Mehta et al demonstrate that intracoronary low-dose alteplase did not improve outcomes in STEMI patients with large thrombus b...

JACC is proud to present research from the PROCTOR trial, and in this video interview with JACC Associate Editor Yousif Ahmad, MD and author Ruben W. de Winter, MD, review the randomized study comparing PCI of native coronary arteries versus saphenous vein grafts in patients with prior CABG. Contrary to expectations, the trial found that at one year, patients treated with vein graft PCI had signif...

JACC continues its collaboration with TCT 2025 in this interview featuring JACC Associate Editor Celina M. Yong, MD, MBA, MSc, FACC, and lead investigator Professor Chao Gao, MD, PhD. The discussion spotlights the 3-year results of the REC-CAGEFREE I randomized trial comparing drug-coated balloons (DCB) with drug-eluting stents (DES) for de novo coronary lesions. Published in JACC and presented at...

In this episode, Dr. Makoto Mori, Associate Editor at JACC and Assistant Professor of Cardiac Surgery at Yale, interviews Dr. Paul Sorajja, lead author of the SUMMIT MAC Trial. They discuss the groundbreaking results of this study, which explores the use of the Tendyne transcatheter mitral valve replacement (TMVR) device in patients with severe mitral annular calcification (MAC)—a group traditiona...

JACC continues to provide context and highlight important content for readers, and our November 4 issue features the High Blood Pressure Guideline surrounded by a series of expert commentaries. In this video interview discussing the commentary on preeclampsia,  JACC Deputy Editor Erica S. Spatz, MD, FACC, speaks with author Vesna D. Garovic, MD, PhD about the complexities of hypertensive disorders...

The High Blood Pressure Guideline is paired with expert commentaries in JACC's November 4 issue. In this video interview focusing on one of the commentaries,  JACC Deputy Editor Erica S. Spatz, MD, FACC, talks with author Daichi Shimbo, MD, about the importance of out-of-office blood pressure monitoring. They discuss the latest guidelines, which give home and ambulatory monitoring the highest reco...

JACC's November 4 issue features the High Blood Pressure Guideline surrounded by a series of expert commentaries. In this video interview, JACC Deputy Editor Erica S. Spatz, MD, FACC, speaks with author Anand Vaidya, MD MMSc. Listen in for an insider view of the evolving understanding of primary aldosteronism in light of the 2025 high blood pressure guidelines. Dr. Vaidya emphasizes that primary a...

JACC is pleased to bring readers several studies and presentations for TCT 2025 this year. In this interview, JACC Senior Advisor. David J. Cohen, MD and Mark A. Hlatky, MD, discuss the cost-effectiveness analysis conducted alongside the FAME 3 trial, comparing PCI guided by fractional flow reserve with CABG. They conclude that while both procedures yield similar long-term clinical outcomes, PCI i...

Heart failure with preserved ejection fraction (HFpEF) has long lacked a unifying biological explanation—until now. In this presentation, Dr. Milton Packer introduces The Adipokine Hypothesis, a new framework that links visceral adiposity to the onset and progression of HFpEF through endocrine signaling between adipose tissue and the heart. Dr. Packer describes how visceral fat acts as an active e...

In this JACC interview, JACC Executive Associate Editor Karthik Murugiah, MD, FACC, speaks with lead author Fabrizio D'Ascenzo, MD, PhD, as they review the randomized, multicenter PULSE trial. In the study (606 patients with unprotected left main PCI), routine 6-month CCTA surveillance did not lower the 18-month composite of death, myocardial infarction, unstable angina, or stent thrombosis compar...

JACC covers the latest science at ESC 2025 in this video interview with Neha J Pagidipati, MD, FACC and Stephen J. Nicholls, MBBS, PhD, FACC. The study, published in JACC and presented at ESC, discusses obicetrapib, a highly selective cholesteryl ester transfer protein inhibitor which lowers LDL-C and Lp(a) and raises HDL-C. This pooled analysis of trials investigating the lipid effects of 12 mont...

Join Milton Packer, MD, FACC as he introduces the Adipokine Hypothesis—a groundbreaking framework for understanding heart failure with preserved ejection fraction (HFpEF). Drawing on decades of research, he explains how excess visceral adiposity alters adipokine biology, shifting from cardioprotective to pro-inflammatory signaling. This shift drives hypertrophy, inflammation, fibrosis, and ultimat...

JACC is proud to publish this video interview with Associate Editor Jason H. Wasfy, MD, MPhil, FACC and Kristoffer Grundtvig Skaarup, MD. In their talk about this paper presented at ESC and simultaneously published in JACC, they discuss this exploratory prespecified analysis of the DAN-RSV Trial. RSVpreF vaccination was associated with reduced risks of RSV-related, respiratory, and cardio-respirat...

JACC Associate Editor Michelle Kittleson, MD, PhD, speaks with author and ESC presenter Milind Desai, MBA. In this video interview related to the ODYSSEY-HCM trials presented at ESC, they discuss key findings published in JACC. The studies reveal promising insights into echocardiographic and biomarker changes, and long-term outcomes in asymptomatic HCM patients. Tune in for expert perspectives on...

JACC's latest research presented at ESC is reviewed here, with JACC: Associate Editor Theresa McDonagh, Bsc, MB ChB, MD speaking with co-authors and ESC presenters John W. Ostrominski, MD and Muthiah Vaduganathan, MD MPH. Listen in as they discuss two synergistic studies presented at ESC and simultaneously published in JACC. Both papers emphasize that BMI alone underestimates obesity prevalence an...

In this JACC interview, Michael Honigberg, MD, MPP joins Mitsuaki Sawano, MD, PhD, to discuss two simultaneous publications presented at ESC 2025 on the role of clonal hematopoiesis of indeterminate potential (CHIP) in cardiovascular disease. They highlight findings from the Women's Health Initiative Long Life Study, which examined CHIP in older women and revealed gene-specific risks (TET2, JAK2,...