Immune

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Alexander Dent Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  ema...

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode COVID-19...

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. Hosts:  Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Cross-reactive coro...

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts:  Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CD8 cells defend against SARS-CoV (J Virol) Deep immune pr...

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for th...

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode How...

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode IL6 as COVI...

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode ACE2 in oral mucosa (I J Oral Sci) IL6 pre...

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Irene Salinas Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Evolution of mucosal Ig in rainbow tr...

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode H3K4me1 mark on memory-like NK cells (Cell Rep) Letters read on Immune 27 Time stamps by J...

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Michael Mina Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Measles virus infection diminishes pre-e...

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CD8+ T cell memory needs microbiome derived fatty acids (Imm...

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode New type of T helper cell drives anaphylaxis (Science) Image credit Time stamps by Jolene . Thanks! Le...

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene . Thanks! Vaccines and Your Child Lette...

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene . Thanks! Letters read on...

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time...

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis.   Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia an...

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease.   Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Maternal immunization protects offspring (Sci Trans Med) Diversity of herpesvirus in neonates ( TWiV 540 ) Mariana Mazzucato on Freakonomics Letters read on Immune...

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Trogocytosis for T cell antigen discovery (Nat Methods) Trogocytosis (J Immunol) Orphan T...

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Darwin Day Metabolic rewiring of macrophages by CpG (Nat Immunol) Letters read on Immune 17 Time stamps by Jolene . Thanks! Weekly Science Picks Steph - Pregnant Scholar Cindy...

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Role of B cell...

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling vid...

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine ( pdf ) What's in a name? (Can Res Inst)...

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes , Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virolog...

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a  patron  of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats ( TWiV 185 ) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science...