Immune

From SLB22 on the Island of Hawai'i, Julia and Musa join Immune to reveal their remarkable career paths, and their research on understanding trained innate immunity. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guests: Julia Bohannon and Musa Mhlanga Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this e...

Somali and Phil join Immune to discuss their approaches to immunology education. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Sumali Pandey and Phil Mixter Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode ImmunoReach ASMCUE: ASM Conference for Undergraduate Educators (ASMCUE) Upcoming...

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be 'good' or 'bad' in their function. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Mandy McGeachy Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links...

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Lin...

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Bacteria induce skin regeneration via IL-1beta (Cell Host Mic...

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guest: Al Singer Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode T cell FlipFl...

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode KIR+CD8+ regulatory T cells...

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Age-dependen...

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts:  Vincent Racaniello , Cynthia Leifer, and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Trogocytosis in Immune 18 B cells steal from dendritic cells (Science) Tim...

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Gabriel Victora Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Concerto in B ( TWiV 161 ) Visualizi...

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Nikhil Joshi Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this...

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode DNA binding to TLR9 on red blood cells (Sci T...

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Keke Fairfax Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Beco...

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Timothy Ha...

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Antiviral IgA potentiates NETosis (PNAS) Lett...

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Dampened STING in bats (Cell...

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this epis...

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Intestinal IgA regulates neuroinflammation (Cell) Time stamps by Jol...

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CAR-T...

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Christian Gaebler Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Evolution of antibody immunity to...

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Madina Wane Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  o...

Immune reminisces about a year in COVID-19 immunology, Steph's receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron...

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Imm...

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Sallie Permar Subscribe (free):  iTunes...

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guests: Alexis Mobley , Joel Babdor , Elaine Kouame , Justine Noel , Ev...