Immune

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections. Hosts:  Cindy Leifer  and  Steph Langel Guest:  Rafael Polidoro Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patro...

Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Stephanie Langel  and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity. Hosts: Cindy Leifer  and  Steph Langel Guest:  Jane Buckner Subscribe (free): Apple Podcasts ,  R...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Tonya Webb Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Music by  Tat...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Michal Tal Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Mus...

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne where meet up with Luis Montaner to talk about his career and his research on boosting the immune system to combat viral diseases or cancer progression. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Luis Montaner Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for th...

Immune travels to Chicago for the American Association of Immunologists conference where they meet up with Joseph Larkin III to talk about his career and his research on the contribution of T lymphocyte subsets and functions in maintaining tolerance. Hosts:  Stephanie Langel  and  Brianne Barker Guest:  Joseph Larkin III Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune!...

Immune presents three stories: intranasal neomycin and antiviral immunity, sexual dimorphism in skin immunity, and maternal diet changes infant microbes that alter gut DC responses and respiratory health. Hosts:  Stephanie Langel ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Intr...

Immune explains how antibody-mediated depletion of myeloid-hematopoietic stem cells in aged mice restores characteristic features of a more youthful immune system, including increasing common lymphocyte progenitors, naive T cells and B cells, while decreasing age-related markers of immune decline. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,...

Immune discusses responses in a COVID hypervaccinated individual, synthetically glycosylated antigens for the antigen-specific suppression of established immune responses,  gut bacteria–derived serotonin promotes immune tolerance in early life, and mucosal and systemic immune correlates of viral control after SARS-CoV-2 infection challenge. Hosts:  Vincent Racaniello ,  Steph Langel ,  Cynthia Lei...

Immune reviews research showing that the migration of neutrophils between endothelial cells activates bactericidal function via mechanosensing. Hosts: Vincent Racaniello ,  Steph Langel ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Trans endothelial migration  ...

Juliet Morrison joins Immune to discuss her career and the research of her laboratory showing that pleural macrophages translocate to the lung during infection to promote improved influenza outcomes. Hosts:  Vincent Racaniello ,  Steph Langel ,  Cynthia Leifer , and  Brianne Barker Guest:  Juliet Morrison Click arrow to play Download Immune 76 (48 MB .mp3, 67 min) Subscribe (free):  Apple Podcasts...

Ang Cui joins Immune to discuss her career and her work on establishing the Immune Dictionary, a compendium of single-cell transcriptomic profiles of more than 17 immune cell types in response to each of 86 cytokines (>1,400 cytokine-cell type combinations) in mouse lymph nodes in vivo. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Guest:  Ang Cui Subscribe (free): Apple Podca...

Carla Nowosad joins Immune to discuss her career and her work on germinal centers, the structure in secondary lymphoid tissues where B cells proliferate, differentiate, and diversify their immunoglobulin genes by somatic hypermutation. Hosts:  Stephanie Langel ,  Cynthia Leifer , and  Brianne Barker Guest:  Carla R. Nowosad Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become...

Immune reveals the total mass (1.2kg), number (1.8 trillion), and distribution of immune cells in the human body, with macrophages contributing nearly 50% of the total cellular mass. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Immun...

From Cornell University in Ithaca New York, Vincent and Cindy meet with Ellen Rothenberg to review her career in science, starting with work on retroviruses to unraveling transcriptional networks underlying T-cell development and signaling. Hosts:  Vincent Racaniello  and  Cynthia Leifer Guest:  Ellen Rothenberg Click arrow to play Download Immune 72 (53 MB .mp3, 73 min) Subscribe (free):  Apple P...

Immune explains how, in a mouse model of roundworm infection with Nippostrongylus brasiliensis , exposure to lung-migrating helminths protects mice against SARS-CoV-2 infection. Hosts:  Cynthia Leifer ,  Stephanie Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Helminth pro...

Immune explains how mast cells, IgE antibody, and the brain collaborate to promote avoidance of certain foods to evade allergic responses. Hosts:  Vincent Racaniello ,  Cynthia Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Mast cells  and immune avoidance behavior (Nature...

Immune discusses immunological imprinting, also called original antigenic sin, in the context of infection with SARS-CoV-2 and influenza virus. Hosts:  Vincent Racaniello , Cynthia Leifer , and Steph Langel Download  Immune 66  (45 MB .mp3, 76 min) Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Immun...

Immune explains the results of a study which show that in mice, functional T cells respond to vaccination for over 10 years and 51 successive immunizations, exhibiting supernumerary cell division and longevity. Hosts:  Vincent Racaniello ,  Cynthia Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for...

Immune discusses the current understanding of immune memory to SARS-CoV-2 infection and COVID-19 vaccines, which supersedes that of any other acute infectious disease. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server COVID-1...

Jon joins Immune to discuss the research of his laboratory on understanding how the innate immune system recognizes and responds to pathogens, and his hypothesis that infection infidelities drive innate immunity. Hosts:  Vincent Racaniello ,  Cynthia Leifer ,  Steph Langel , and  Brianne Barker Guest:  Jonathan C. Kagan Subscribe (free): Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a ...

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of...

Cindy, Steph, Brianne, and Vincent review some of their favorite immunology papers of 2022. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CAR T for SLE (Nat MEd) Maternal gut microbiome induced IgG (Sci Immunol) Long-primed germinal centers (Nat...

De'Broski joins immune to reveal his remarkable career path and the research of his laboratory on neuroimmunology and the immune response to parasite infections. Hosts:  Vincent Racaniello , Cynthia Leifer , Steph Langel , and Brianne Barker Guests D'Broski Herbert Subscribe (free):  Apple Podcasts ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Immunology of...