Immune

The whole Immune gang gathers with special guests Gretchen Diehl and Shruti Naik at The Incubator with an audience to celebrate the 100th episode. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Stephanie Langel,  and  Brianne Barker Guests:  Gretchen Diehl  and  Shruti Naik Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server...

David Schatz talks about his discovery of Rag genes that are critical for antigen receptor development and how that discovery depended on taking high risks and using approaches that everyone thought could never work. Host:  Cindy Leifer Guest:  David Schatz Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server T ransfer of re...

The Immune team discusses the groundbreaking discoveries of regulatory T cells, which was the topic of the 2025 Nobel Prize in Physiology or Medicine. Hosts:  Vincent Racaniello ,  Cindy Leifer , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Sakaguchi lab  paper on FoxP3 and regulatory T cells  (Sci...

Susan Schwab talks about how she got the research bug, bugs she ate, and her research on how the lipid S1P helps T cells decide- should I stay or should I go. Host:  Cindy Leifer Guest: Susan Schwab Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Schwab lab  website Monocytes  produce the lipid S1P  to regulate T cell m...

Immune discusses cross-reactive antibodies to avian influenza neuraminidases and a role for gut-derived T cells in the brain to regulate eating behavior.   Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Antibody  cross-reactivity to influen...

Kristian Andersen from Scripps Research Institute joins Cindy to talk about how he got interested in virus evolution, how the immune system drives viral adaptation, and what we can learn from this research to better prepare us for the next pandemic. Host:  Cindy Leifer Guest:  Kristian Andersen Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode Mi...

Cindy and Steph discuss a paper that challenges the textbook dogma that B cells must first bind to an antigen for antibody affinity maturation to occur, and a snippet on dysfunctional T cells during bacterial vaginosis. Hosts:  Cindy Leifer  and  Steph Langel Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Somatic  hyper...

Cindy sits down with Bali Pulendran at the AAI 2025 meeting where he told the story of how a childhood fascination with the cosmos grew into a career addressing fundamental questions about the human immune response, and how when an antigen enters the body it is like the big bang in how it initiates immune responses. Host:  Cindy Leifer Guest:  Bali Pulendran Subscribe (free): Apple Podcasts ,  RSS...

Elizabeth Marnik, also known as Science Whiz Liz, grew up unvaccinated, yet she is now an immunologist, science communicator, and advocate for vaccines–this is her story.    Host:  Cindy Leifer Guest:  Elizabeth Marnick Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server More about Liz on her  webpage ScienceWhizLiz  on Inst...

Immune discusses the potential future of delivering vaccines by flossing your teeth and how antibodies in human milk shape the normal immune responses in newborns.  Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server Floss-based  vaccination (N...

Cindy speaks with Aimee Pugh Bernard from University of Colorado about her career and her passion for teaching and communicating immunology to the public.    Host:  Cindy Leifer Guest:  Aimee Pugh Bernard Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Server More about Aimee on her  webpage Funsizeimmuninja  on Instagram Fun S...

Immune discusses how cancer cells swap mitochondria with T cells and then digs in for a discussion of an unusual checkpoint blockade that failed for cancer but could be repurposed for autoimmune inflammation. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV...

Cindy talks with Shane Crotty about his teenage days driving 3 ½ hours every weekend to have his first research experience in marine biology, how that eventually led to studying how vaccines work and how we can make them better, and how immunology research and publishing got a turbo-boost during the pandemic. Hosts:  Cindy Leifer Guest:  Shane Crotty Subscribe (free):  Apple Podcasts ,  RSS ,  ema...

The Immune team goes up the nose to discuss cytotoxic T cells activating complement through secretion of granzyme K to drive inflammatory nasal polyps and how IgA-producing B cells are made in the nose. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Disc...

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne talk with Darren Lee to discuss his career, how he got interested in immunology of the eye, and how his team visualizes immune responses of the eye in real time with the hope of better understanding autoimmune uveitis. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Darren Lee Subscribe (free): Apple Podcasts ,  RSS ,  email...

Vincent and Cindy discuss differences between MPox-specific T cell responses following infection and vaccination, and lymph node macrophage control of memory B cell localization and trafficking that might be important for choosing which arm to get a vaccine. Hosts:  Vincent Racaniello  and  Cindy Leifer Subscribe (free):  Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this e...

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne sit down with Justin Wilson to talk about how he got into research and his more recent studies on innate immune sensors and the interaction between the gut microbiome and inflammation related to inflammatory bowel disease and cancer. Hosts: Cindy Leifer  and  Brianne Barker Guest:  Justin Wilson Subscribe (free): Apple Podcasts...

Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free):  Apple Pod...

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Holger Heine about the discovery of immune recognition of bacterial lipopolysaccharide and innate immunity to organisms within the kingdom Archaea. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Holger Heine Become a patron  of Immune! Links for this episode MicrobeTV Discord Server TLR8 recognizes human  gut-associated arch...

Immune talks with David Peterson and Kim Klonowski from the University of Georgia about their careers, their People, parasites, and plagues podcast, placental malaria immunity, and and how interferons in the thymus affect T cell repertoire selection. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Guests:  David Peterson  and  Kim Klonowski Subscribe (free): Apple...

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Amy Hise about her career in science, her current research using mouse models for investigating fungal immunity and navigating the challenges of being a mom in science. Hosts:  Cindy Leifer  and  Brianne Barker Guest:  Amy Hise MicrobeTV Discord Server Mouse model for testing  drugs to treat Candida fungal infection Inflammasom...

Immune 90: Immunology of Injury March 25, 2025 From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune's Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and immunity during trauma. Hosts: Cindy Leifer  and  Brianne Barker Guests:  James Lederer  and  Elizabeth Kovacs Subscribe (free):  Apple Po...

Immune Booster #10 HIV in the brain with Amanda Brown March 18, 2025 From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection. Hosts:  Cindy Leife...

Immune discusses how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens. Hosts:  Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this e...

Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis. Hosts: Vincent Racaniello ,  Cindy Leifer ,  Steph Langel , and  Brianne Barker Subscribe (free): Apple Podcasts ,  RSS ,  email Become a  patron  of Immune! Links for this episode MicrobeTV Discord Se...