Vincent Racaniello

Immune

Science EN ↓ 136 episodes

A podcast about the body's defenders against disease.

Author

Vincent Racaniello

Episodes

Immune 11: Immunomimetic designer cells 18.08.2018 1:08:33

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent...

Immune 10: Immune goes viral 21.07.2018 1:15:39

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Rebecca Lynch Become a patron of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal . Immune logo i...

Immune 9: Neither mice nor lamprey lie 20.06.2018 1:35:11

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Lamprey VLR response to influenza virus (eLife) VLR-based immunity (Ann Rev Immunol) How the Immune Sy...

Immune 8: Staying warm with γδ T cells 25.05.2018 1:19:29

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode γδ17 T cells , T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers (Nat Rev Immunol) Image credit Le...

Immune 7: Contradictory complements in Alzheimer's disease 18.04.2018 1:13:05

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's (Science) Superresolution structured illumination microscopy Image credit Weekly Sci...

Immune 6: Potent antiviral antibodies without somatic mutation 16.03.2018 1:29:03

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine e...

Immune 5: Mother knows best about food allergies 22.02.2018 1:40:57

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy (Nat Rev Dis Prim) Maternal allergen sensitization (J Exp Med) Image credit Letters read on Immune #5 Mu...

Immune 4: Putting the immunotherapy CAR T before the cancer 23.01.2018 1:23:15

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells...

Immune 3: Two epitopes, four serotypes, and a partridge in a pear tree 16.12.2017 1:19:15

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Model for dengue ADE (Scitable) Dengue ADE in humans (Science) Dengvaxia discussion ( TWiV 471 ) Bi-specific antibody to Zika virus (Cell) Buildin...

Immune 2: Lymphocytes after dark 25.11.2017 1:26:55

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Circadian clocks control lymphocyte trafficking (Immunity) Lymph node image credit Letters read on Immune #2 Weekly Science Picks Cindy -...

Immune 1: Some like it hot 31.10.2017 1:05:31

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts: Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Become a patron of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res)...