Gyno Gurus Podcast

In this episode of the Gyno Gurus Podcast, we break down the emerging concept of PMOS (Polyendocrine Metabolic Ovarian Syndrome) and why many experts believe the term “PCOS” may no longer fully capture what’s really happening in the body. We explore how genetics, epigenetics, insulin resistance, brain signaling, ovarian dysfunction, and androgen excess may all converge through different pathways t...

If you’ve ever been told you have PCOS—or think you might—you’re not alone… but you may not have gotten the full picture.   In Part 1 of this PCOS series, we break down what PCOS actually is (and what it isn’t), why it’s called a syndrome, and how it’s diagnosed in real clinical practice. We also dive into common symptoms, ultrasound criteria, and the metabolic connections that are often overlooke...

Is PMS really “all in your head”? 🤔   In this Fact or Fiction episode of the Gyno Gurus Women’s Health Podcast, we break down one of the most dismissive myths in women’s health—and replace it with actual physiology.   We dive into what’s really driving PMS and PMDD, from hormonal signaling and progesterone sensitivity to neurotransmitters like serotonin. We also explore evidence-based treatments...

Can you get pregnant on your period? Is Natural Family Planning only for women with “perfect” cycles? Does birth control protect—or harm—future fertility? In this Fact or Fiction episode of the Gyno Gurus Podcast, we break down three of the most common fertility myths. We’ll walk through how the menstrual cycle actually works, why cervical mucus matters more than most people realize, how LH surge...

Human Papillomavirus (HPV) is one of the most common sexually transmitted infections—but there’s a lot of confusion, fear, and misinformation surrounding it. In this episode of The Gyno Gurus Podcast, we break down HPV in a clear, evidence-based, and patient-centered way.   We cover what HPV actually is, how it’s tested, how it relates (and doesn’t always relate) to cervical cancer, and what preve...

Unlock the essentials of hypothyroidism, thyroid optimization, Hashimoto’s, and evidence-based treatment options in this deep-dive episode. Whether you're a clinician, patient, or someone trying to understand thyroid health, this video breaks everything down in a clear, practical way.   We cover the anatomy & physiology of thyroid regulation, the differences between TSH, T4, T3, and Reverse T3...

The FDA has officially begun removing the long-standing Black Box warnings from Hormone Replacement Therapy (HRT) products — a major shift after more than two decades of confusion, fear, and misinformation. In this video, we break down what this change means, why it’s happening now, and how it impacts women using HRT for menopause symptom relief and long-term health.   We walk through the history,...

In this episode, we break down three of the most talked-about tools in metabolic health — Allulose, Metformin, and GLP-1 agonists (like Ozempic) — and explore how each impacts insulin resistance, glucose regulation, and metabolic health. We start with a clear overview of insulin resistance, then dive deep into the science of Allulose, how Metformin improves mitochondrial and hepatic function, and...

🧠 Insulin Resistance: Exercise, Lifestyle, and Supplements (Myo-Inositol & Berberine)   In this episode, we break down how exercise, nutrition, and evidence-based supplements can improve insulin sensitivity and metabolic health. Learn how muscle mass, time-restricted feeding, and protein intake all play key roles — plus how myo-inositol, berberine, and allulose may support glucose control thr...

In this Clinical Conversations episode, we bring insulin resistance to life through a real patient story — showing how disrupted blood sugar balance can ripple through a woman’s hormonal cycle. We walk through her cycle charts, hormone patterns, and lab results, including fasting insulin, glucose, and OGTT with insulin response — uncovering how insulin resistance was silently affecting ovulation,...

Today we’re breaking down insulin resistance — what it really means, why it happens, and how you can spot it early. We’ll walk through what’s actually going on in your body when your cells stop responding to insulin, how that leads to cravings, fatigue, and weight gain, and which tests can help you find out if you’re at risk.   💡 In this episode: What insulin resistance actually is (in plain Engl...

Insulin Resistance: What it is, how to test it, and evidence-based ways to improve it. In this episode we break down insulin’s role in metabolism, the difference between normal vs optimal glucose/insulin ranges, the most useful labs (and how to read them), and practical strategies that can improve insulin sensitivity.   Your Hosts: Alexandra Marks, WHNP-BC Peter Mandel, MD, FACOG   Follow us on In...