Gut Podcast

The glands of the stomach body and antral mucosa contain a complex compendium of cell lineages. In lower mammals, the distribution of oxyntic glands and antral glands define the anatomical regions within the stomach. Now a paper in Gut has examined in detail the distribution of the full range of cell lineages within the human stomach. Mairi McLean talks to authors James Goldenring, Eunyoung Choi a...

Mairi McLean talks to Krisztina Gecse about the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease. Read the related article: http://gut.bmj.com/content/63/9/1381.full

The identification of a distinct syndrome, designated eosinophilic oesophagitis (EoE), with its own clinical and histopathological characteristics, was first described in the early 1990s. Meanwhile intense research has uncovered many molecular, immunological and clinical aspects of this chronic-inflammatory disorder. In this podcast, Mairi McLean talks to Professor Alex Straumann, Swiss EoE Clinic...

Inflammatory bowel disease is driven by a seemingly aberrant immune response to the gut microbiota with disease development dictated by genetics and environmental factors. A model exemplifying this notion is work by Andrew Gewirtz, Center for Inflammation, Immunity, & Infection, Georgia State University, and colleagues, demonstrating that colonisation of adherent-invasive Escherichia coli (AIE...

Despite the success of hepatitis B virus vaccination in preventing new infection in endemic areas, chronic hepatitis B still poses a heavy burden globally. There are approximately 350 million carriers in the world, with an estimated 60 000 persons dying annually of hepatitis B-related cirrhosis and hepatocellular carcinoma. In a study recent published in Gut, Professor Man-Fung Yuen, Department of...

Mairi McLean talks to Robin Spiller, NIHR Nottingham Digestive Diseases Biomedical Research Unit, and David Tooth, School of Biomedical Sciences, University of Nottingham, about their paper: Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit. Read the full article: http://goo.gl/0OIP34

Mairi McLean talks to Andres Acosta and Barham K Abu Dayyeh, both Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, about their review on the management of obesity. Read the full paper: http://goo.gl/V37xaq

Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity and mortality in neonates and alternative strategies are needed. Stem cells have become a therapeutic option for other intestinal diseases, which share some features with NEC. Along with colleagues, Simon Eaton and Paolo De Coppi, both from University College London Institute of Child Health, have tested the hypothesis...

Gut's education editor Mairi McLean discusses highlights from the guidelines on the diagnosis and management of Barrett's oesophagus with authors Rebecca Fitzgerald and Massimiliano di Pietro, both from the MRC Cancer Unit, University of Cambridge. Read the full paper here: http://bit.ly/1kkPkVW

Mairi McLean talks to Markus Peck-Radosavljevic, Division of Gastroenterology & Hepatology, Medical University Vienna, about his study looking at carvedilol for primary prophylaxis of variceal bleeding in cirrhotic patients with haemodynamic non-response to propranolol. Read the full paper here: bit.ly/1991biw

Mairi McLean talks to Anna Paterson and Rebecca Fitzgerald, both MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, about their study investigating whether a receptor tyrosine kinase (RTK) array could be used to select the most effective therapeutic strategies in molecularly heterogeneous oesophago-gastric adenocarcinomas. Read the full paper here: bit.ly/1acACwz

Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. In this podcast Mairi McLean, Gut education editor, talks to Professor Yoshiro Niitsu from Sapporo Medical University School of Medicine about his manuscript about the potential for therapeutic use of siRN...

Mairi McLean talks to Patrick Tan, associate professor, Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School Singapore, and Heike Grabsch, Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, about their genomic meta-analysis to identify predictors of survival in patients with gastric cancer. See also: Comprehensive genomic meta-analysis identifies in...

Mairi McLean talks to Emeran Mayer, Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, UCLA, about his paper: An update on the use and investigation of probiotics in health and disease. Read the full paper here: http://bit.ly/11ghKss

In this podcast, Mairi McLean interviews Julián Panés and Azucena Salas, both from the Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBER-EHD in Barcelona, Spain. They disuse their recent article, looking at transcription in the intestinal mucosa of patients with ulcerative colitis. read the full article online: http://tinyurl.com/n3uy6d4

Mairi McLean talks to Philip Rosenstiel, Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, and Stefan Schreiber, University Hospital Schleswig-Holstein, Kiel, about their paper: mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn’s disease http://bit.ly/11FU0Qw.

Mairi McLean, Gut’s education editor, talks to Xavier Hébuterne, Department of Gastroenterology and Nutrition, Archet Hospital, Nice, and Jean-Frédéric Colombel, Universite Lille Nord de France, about their paper: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol http://bit.ly/10dtab8.

Before the UK national bowel cancer screening programmes were implemented, a pilot was set-up in England to see if results from randomised controlled trials could be replicated in the general population. Gut has recently published findings from the third round of this. Co-author David Weller, Centre for Population Health Sciences–General Practice, University of Edinburgh, UK, talks to Gut’s associ...

Mairi McLean, Gut education editor, talks to Professor Mark Hull, Leeds Institute of Molecular Medicine, about his research into the action of polyunsaturated fatty acids on the formation of neoplams. See also: Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer (http://tinyurl.com/a7q8co4)

In the UK chronic gastrointestinal symptoms after cancer therapies have a similar impact as IBD. However, in contrast to patients with IBD, most of these patients won’t see a gastroenterologist. In this month’s Gut Editor’s Choice the causes of these side effects of cancer treatment are discussed, as well as the benefits of investigation and treatment. In this podcast Mairi McLean, senior clinical...

Liam O’Mahony (Swiss Institute of Allergy and Asthma Research) talks to Mairi McLean (senior clinical lecturer and consultant in gastroenterology at the University of Aberdeen) about his paper looking at Bifidobacterium infantis’s interaction with T cells, and the bacterium’s potential to protect against gastrointestinal inflammation. See also: Bifidobacterium infantis 35624 administration induces...

Mairi Mclean, Gut’s education editor, talks to Matteo Serino from the Institut National de la Santé et de la Recherche Médicale (INSERM), about his article Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota (http://tinyurl.com/a4rdl2e), which is this month’s editor’s choice.

Gut education editor Mairi Mclean talks to Professor Peter Malfertheiner, from the European Helicobacter Study Group, about the May editor’s choice paper: Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report. See also: Guidelines: Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report (http://tinyurl.com/bj2zn2g)

Gut education editor Mairi Mclean talks to Dr Shuji Ogino, from Harvard Medical School, about his paper on the asessment of colorectal cancer molecular features. See also: Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum (http://tinyurl.com/bgs7o7u)

Mairi Mclean (Gut education editor) talks to Maria Rescigno (European Institute of Oncology, Milan) about her editor’s choice paper - Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. (http://tinyurl.com/a8z4uqr)