Evidence Based Medicine presented by InpharmD™

Early data suggests the incidence of true anaphylaxis to the Pfizer-BioNTech COVID-19 vaccine is rare (11.1 cases per million vaccine doses). Anaphylaxis is more common in women and persons with a history of allergies, and symptoms typically appear within 30 minutes of injection.

A retrospective, observational, cohort study done to assess whether a diagnosis of a schizophrenia spectrum disorder, mood disorder, or anxiety disorder is associated with mortality in patients with COVID-19.

A randomized, multicenter, double-blind, placebo-controlled, phase 1/2a clinical trial to evaluate the safety, reactogenicity, and immunogenicity of Ad26.COV2.S - a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike (S) protein

An observational cohort study performed to describe characteristics and outcomes of hematopoietic stem-cell transplantation (HSCT) recipients after developing COVID-19

A prospective, randomized, open-label trial performed to evaluate whether continuation of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) is beneficial or harmful in patients who are admitted to hospital with COVID-19.

A cohort study done to comparatively examine differences in risk of clinical manifestations and death among people admitted to hospital with coronavirus disease 2019 (COVID-19) and seasonal influenza.

A phase 3 randomized, stratified, observer-blinded, placebo-controlled trial to to assess the safety and efficacy of the mRNA-1273 vaccine in preventing SARS-CoV-2 infection. 

A randomized, multicenter, adaptive, double-blind, placebo-controlled trial to evaluate whether the combination of baricitinib plus remdesivir was superior to remdesivir alone.

A comparative study done to evaluate the fitted filtration efficiency (FFE) of various consumer-grade and improvised face masks, as well as several popular modifications of medical procedure masks that are intended to improve mask fit or comfort.

A case report describing two monozygotic twins with different clinical courses, despite having the same environment and genomic factors. 

A retrospective, cohort study conducted to determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19

A randomzied, double-blind, placebo-controlled, multicenter, phase 2, pilot trial conducted to determine whether inhaled SNG001 (recombinant interferon beta-1a) has the potential to reduce the severity of lower respiratory tract illness and accelerate recovery in patients diagnosed with COVID-19. 

The purpose of this study was to evaluate the efficacy and safety of LY-CoV555 (bamlanivimab) in patients with recently diagnosed mild or moderate COVID-19 in the outpatient setting

What does the evidence says on the safety and immunogenicity of pfizer's potential vaccine - BNT162b2 - as compared to other candidates?

A cohort study examining levels of severity of depressive symptoms over time among individuals with high risk in the UK during the COVID-19 pandemic

A randomized, double-blind, placebo-controlled trial conducted to assess if early intervention with interleukin-6 receptor blockade might limit COVID-19 progression to hypoxemic respiratory failure or death, reduce the risk of clinical worsening, and decrease the duration of supplemental oxygen use. 

A 25-year old male patient was infected on two separate occasions, with the second infection being symptomatically more severe than the first. Genomic analysis showed the two viral agents were genetically distinct.

The objective of this study was to evaluate the clinical efficacy and safety of remdesivir among hospitalized adults with laboratory-confirmed COVID-19.

The objective of the cohort study was to investigate the effect of serum testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 in SARS-CoV-2 infected male patients

The objective of this study was to use the Extracorporeal Life Support Organization (ELSO) Registry to report the epidemiology, treatment, outcomes, and hospital characteristics of patients receiving extracorporeal membrane oxygenation (ECMO)with a confirmed diagnosis of Corona Virus Disease 2019 (COVID-19).

A study to determine the risk of hospitalization, mechanical ventilation, and death associated with infection; and to identify characteristics independently associated with these outcomes in patients who tested positive for severe acute respiratory syndrome coronavirus 2. Read more: inpharmd.com/covid 

What does the evidence say on the safety and immunogenicity of the new Novavax vaccine for the SARS-CoV-2 infection?

Is cell phone location data associated with the rate of change in new COVID-19 cases by county across the US? Tune in to what the evidence say.

An open-label, non-randomized, single-arm, Expanded Access Program (EAP) trial conducted to explore potential signals of efficacy of COVID-19 convalescent plasma. Read more here: inpharmd.com/covid 

A prospective, multi-center, single-blind, randomized controlled phase II trial assessing the efficacy and safety of ruxolitinib in hospitalized COVID-19 patients