Decera Clinical Education Infectious Disease Podcast

In this episode, Angela Branche, MD, discusses the Advisory Committee on Immunization Practices recommendations for RSV vaccines in older adults, including:  Use of shared clinical decision-making  How to approach the conversation about the RSV vaccine with patients Key populations who may benefit the most, such as those at risk for severe RSV disease (eg, increasing age and persons who are frail...

In this episode, Renslow Sherer, MD, discusses managing virologic failure in a person living with HIV who is heavily treatment experienced, including: Guideline recommendations for selecting a new ART regimen Options for patients with multidrug-resistant HIV from existing drug classes and novel mechanisms of action with no cross-resistance Data from TMB-301 and TMB-311 for ibalizumab, BRIGHTE for...

In this episode, Oni Blackstock, MD, MHS, and Brittany Williams, PhD,discuss key considerations to pre-exposure prophylaxis (PrEP) uptake in cisgender women, including:  The misconception by patients and healthcare professionals (HCP) that cisgender women are at low risk for HIV  Reframing HIV prevention from “risks” to “reasons” such as promoting self-care and taking control of one’s own sexual h...

In this episode, Kyle Molina, PharmD, BCIDP, discusses key considerations for successful implementation of long-acting lipoglycopeptides into clinical practice. Listen as he gives perspectives on: Reasons to consider use of long-acting lipoglycopeptides (eg, poor adherence to oral antibiotics, PICC-related costs and complications) Data supporting and challenging cost effectiveness of long-acting l...

In this episode, Joseph Ahn, MD, MS, MBA; Christina Delacruz Leyson, MD; and Alice Chan, a person who experienced pregnancy as a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in people of childbearing potential and their infants, including: HBV screening and vaccination in pregnancy Management of pregnant people who are HBsAg positive Infant care Bre...

In this episode, Daniel R. Kuritzkes, MD, and Cristina Mussini, MD, discuss managing ART failure, including: The definitions of virologic blips, low-level viremia, and virologic failure on ART The infrequency of failure with resistance on first-line INSTI-based ART and the instances where this has occurred with BIC- and DTG-based ART in clinical trials and in the real world The potential reasons f...

In this episode, Renslow Sherer, MD, discusses managing a first ART failure in the setting of COVID-19, including: Guideline recommendations for resistance testing Guideline recommendations for selecting a new ART regimen Data on retained efficacy of NRTIs in second-line regimens in the EARNEST and NADIA studies Consideration of drug‒drug interactions between ART and COVID-19 treatment Presenter: ...

In this episode, Kenyon R. Farrow and Raphael J. Landovitz, MD, MSc, discuss key considerations to PrEP uptake in transgender individuals and racial and ethnic minority men who have sex with men, including:  Rates of HIV diagnoses in Black and Brown communities Issues stalling success in HIV prevention (eg, stigma, healthcare coverage, and administration and operational barriers) Considerations fo...

In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD, and Meredith Clement, MD, discuss PrEP initiation, including: The importance of taking a sexual history and getting to know your patient Recommendations for who should be considered for PrEP Practicalities of PrEP initiation including laboratory assessments, interview and physical exam, evaluating concomitant medications, counsel...

In this episode, Stefan Zeuzem, MD, discusses new data on viral hepatitis presented at EASL 2023, including: Hepatitis B virus Durability of response with bepirovirsen HBsAg loss with siRNA VIR-2218 combined with either VIR-3434 (novel monoclonal antibody) or pegIFN-alfa Hepatitis delta virus 96-week follow-up of immediate vs delayed bulevirtide Off-treatment response for lonafarnib + ritonavir ±...

In this episode, Kyle Molina, PharmD, BCIDP, provides an overview of treatment of skin and soft tissue infections (SSTIs) and challenges in practice. Listen as he gives perspectives on: Guideline recommendations for treatment of purulent and nonpurulent SSTIs Logistical challenges with IV and oral antibiotics Pros and cons of various locations of care Data supporting the safety and efficacy of lon...

In this episode, Latesha Elopre, MD, MSPH, and Jason Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN, answer questions about HIV PrEP including: How long someone can receive PrEP and the monitoring that is needed over time Recommendations for monitoring bone health while receiving oral PrEP Treatment as prevention and PrEP efficacy data and options for people who inject drugs The role of circumcision...

In this episode, Milena Murray, PharmD, MSc, BCIDP, AAHIVP, FCCP, and Kevin Astle, PharmD, BCPS, BCACP, AAHIVP, CDCES, discuss key considerations to barriers to PrEP uptake, including: Limited data on “on-demand” PrEP in cisgender women  Strategies on improving communication with non‒English-speaking populations  Role of pharmacists with injectable PrEP  CDC PrEP guideline recommendations on routi...

In this episode, Robert S. Brown, Jr., MD, MPH; Nancy Reau, MD; and Eric, a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in older adults, including: Awareness of HBV and CHB in older adults Updated HBV screening and vaccination recommendations Monitoring of renal and bone disease Adjustment of monitoring and treatment as a person with HBV ages Prese...

In this episode, Tarik Asselah, MD, PhD, and Ira Jacobson, MD, provide expert insight on HDV screening, diagnosis, and management, including: Approach to screening Barriers to screening (eg, test availability) Disease progression and complications Differentiating between coinfection and superinfection Approach to treatment (eg, whom to treat and when, treatment options, considerations for combinat...

In this episode, Helen Y. Chu, MD, MPH, shares updates on RSV vaccines, including: An overview of vaccine candidates under investigation Recently FDA-approved RSV vaccines for older adults Considerations for the next respiratory viral season Coadministration of RSV vaccines with other respiratory viral vaccines (eg, influenza, SARS-CoV-2) Target populations for RSV vaccination RSV prevention in in...

In this episode, Nancy Reau, MD, and Heiner Wedemeyer, MD, provide expert insight on HDV management, including: Use of noninvasive imaging or biopsy for staging liver disease Screening for hepatocellular carcinoma HBV treatment Role of comedications (eg, erythropoietin, eltrombopag) Approach to complex cases, such as patients with: Significant fibrosis and low HDV RNA levels Hepatitis delta antibo...

In this episode, Maunank Shah, MD, PhD, discusses using HIV-ASSIST to optimize treatment for both HIV and hyperlipidemia. Listen as he covers: Hyperlipidemia and cardiovascular disease risk among people living with HIV Recommendations for lipid screening for people living with HIV Using HIV-ASSIST to support ART treatment decisions for people living with HIV with comorbidities How HIV-ASSIST prior...

In this episode, Martin Krsak, MD, MSc, FASAM, provides background and context on skin and soft tissue infections. Listen as he gives perspectives on: Epidemiology and clinical outcomes Economic impact Bacterial etiology Importance of appropriate antimicrobial prescribing Clinical presentation Severity classification and distinction between purulent and nonpurulent infections Role of incision and...

In this episode, Marta Boffito, MD, PhD, FRCP, and Michelle Cespedes, MD, MS, discuss initial ART options, including: Recommended first-line ART options for most PWH according to DHHS, IAS-USA, EACS, BHIVA, and WHO guidelines  Data for weight gain after ART initiation with different ARV classes and drugs Weight gain disparities by race and gender after ART initiation Data from the RESPOND study in...

In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for PWH coinfected with HBV and HCV. Listen as she covers: How HIV-ASSIST supports ART selection in primary care Updates to viral hepatitis recommendations including:                CDC HBV screening and testing recommendations              AASLD simplified HCV treatment appro...

In this episode, Amanda Binkley, PharmD, BCIDP, AAHIVP, and Nimish Patel, PharmD, PhD, AAHIVP, discuss clinically relevant data on long-acting ART from CROI 2023, including: LA CAB + RPV in San Francisco’s Ward 86 Safety Net Clinic Serving Publicly Insured PWH SOLAR: Randomized Switch to LA CAB + RPV From BIC/FTC/TAF Amanda Binkley, PharmD, BCIDP, AAHIVP Clinical Pharmacy Specialist  Infectious Di...

In this episode, Christine Katlama, MD, and Babafemi Taiwo, MBBS, discuss optimizing ART for people with HIV who are treatment experienced or failing a current ART regimen, including: Recycling agents from the NRTI, NNRTI, INSTI, and PI classes in salvage ART regimens Maintaining NRTIs in second-line and salvage ART regimens, including the use of 3TC, TFV, and ABC ART regimen simplification When t...

In this episode, Sonya Krishnan, MD, MHS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for a virologically suppressed PWH who is planning a pregnancy. Listen as she covers: How to input patient specific factors into the HIV-ASSIST tool Discussion of available education sheets to review the data and recommendations for her current ART regimen in pregnancy An explanation of w...

In this episode, Ian Frank, MD, discusses long-acting HIV treatment with cabotegravir plus rilpivirine for people with HIV, including: Efficacy data with every-8-week dosing Real-world use in people with viremia  Initiation and continuation strategies Virologic failure data Safety information   Presenter: Ian Frank, MD Associate Chief Division of Infectious Diseases Professor of Medicine Universit...