Decera Clinical Education Infectious Disease Podcast

In this episode, Patrick W. G. Mallon, MB, BCh, PhD, FRACP, FRCPI, discusses new data on COVID-19 presented at ECCMID 2023, including: Treatment in special populations REDPINE: remdesivir in people with renal impairment hospitalized for COVID-19 pneumonia Remdesivir and readmission for COVID-19 in immunocompromised patients Molnupiravir vs nirmatrelvir plus ritonavir for COVID-19 with hematologic...

In this episode, Renslow Sherer, MD, and Trinh P. Vu, PharmD, BCIDP, discuss strategies for managing ambulatory patients with acute or previous COVID-19 infection, including: Current COVID-19 landscape Rapid antigen tests and PCR tests Risk stratification of patients who have a positive SARS-CoV-2 test Antiviral treatment (nirmatrelvir + ritonavir, remdesivir, and molnupiravir) Long COVID Presente...

In this episode, David van Duin, MD, PhD, FIDSA, FAST, discusses new data on complicated clinical infections presented at ECCMID 2023, including: Gram-negative resistance Pharmacokinetic and clinical outcomes in patients receiving meropenem/vaborbactam for KPC-producing carbapenem-resistant Enterobacterales infections Comparative study of cefiderocol- vs colistin-containing regimens for CRAB VAP w...

In this episode, Tracey Piparo, PA-C, and Renslow Sherer, MD, discuss cases of nonhospitalized patients with COVID-19, including: Young, healthy patient with no risk factors Young, healthy patient with risk factors Older patient with immunocompromise Older patient with renal dysfunction Patient experiencing hypoxia  Presenters:  Tracey Piparo, PA-C  Department of Palliative Medicine  RJWBarnabas ...

In this episode, Tatyana Kushner, MD, MSCE, and Stefan Zeuzem, MD, address key considerations when screening, diagnosing, and treating patients with HDV, such as: Barriers to HDV screening, including limitations to AASLD guideline recommendations Use of double reflex testing to improve HDV diagnosis Considerations for repeat HDV testing in patients who are HBsAg positive who previously tested nega...

In this episode, Joseph Lim, MD; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and Jennifer Wild, MS, BSN, RN, OCN, discuss strategies for overcoming barriers to HBV care in Asian American people, including: HBV-related stigma Language barriers Health insurance navigation Presenters: Joseph Lim, MD Professor of Medicine  Director, Clinical Hepatology Vice-Chief, Section of Digestive Diseases Yale Unive...

In this episode, Essa Mohamed, PhD; Daouda Ndiaye; and Ponni Perumalswami, MD, MS, discuss strategies for overcoming barriers to HBV care in African immigrant people, including: HBV awareness and misconceptions HBV-related stigma Language barriers Health insurance navigation Presenters:   Essa Mohamed, PhD Clinical Researcher Division of Gastroenterology and Hepatology Mayo Clinic Rochester, Minne...

In this episode, Daniel R. Kuritzkes, MD, discusses considerations for patients experiencing weight gain on antiretroviral therapy, including: • Commonly implicated antiretroviral therapy regimens and patient populations • Guideline recommendations for management of weight gain Presenter: Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Inf...

In this episode, Isolde Butler, MD, and Brenda E. Crabtree Ramírez, MD, discuss rapid ART initiation for people newly diagnosed with HIV, including: The HIV care continuum in the United States and Latin America Barriers to HIV diagnosis, including stigma, discriminatory laws and policies, social determinants of health, and lack of access to healthcare Factors that predict delayed care linkage and...

In this episode, Daniel R. Kuritzkes, MD, discusses considerations for rapid initiation of antiretroviral therapy in patients who are newly diagnosed with HIV, including: Recommended regimens Management of patients previously receiving PrEP Timing of laboratory testing Presenter: Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Infectious D...

In this episode, 2 HIV experts from the Asia-Pacific region share their thoughts on some of the most important new insights from HIV treatment and prevention research over the past year. Specifically, the faculty discuss the role of newer innovations in HIV, including 2-drug oral antiretroviral therapy (ART) regimens, 2-drug long-acting injectable ART, and long-acting HIV pre-exposure prophylaxis...

In this episode, Angela Branche, MD, and Helen Y. Chu, MD, MPH, discuss the clinical presentation of respiratory syncytial virus (RSV) in adults and the importance of early detection, including:   Clinical symptoms and presentation   Complications, including exacerbations of cardiopulmonary diseases Use of medical resources compared with other respiratory viruses Diagnostic approaches and challeng...

In this episode, Angela Branche, MD, and Helen Y. Chu, MD, MPH, discuss the impact of respiratory syncytial virus (RSV) and describe those at risk for severe RSV disease, including:  RSV prevalence and seasonality   RSV burden throughout life, including burden in older adults Comorbidities that increase the risk of RSV complications   RSV transmission in the hospital and care home setting Implicat...

In this episode, José R. Arribas, MD, and Melissa Badowski, PharmD, MPH, FIDSA, FCCP, BCIDP, BCPS, AAHIVP, discuss optimizing antiretroviral therapy (ART) for people with HIV who are treatment experienced or failing a current ART regimen, including: The use of proviral DNA genotyping for switching therapy Maintaining nucleos(t)ide reverse-transcriptase inhibitors after a first failure The role of...

In this episode, Darrell H. S. Tan, MD, FRCPC, PhD, and Kenric Ware, PharmD, AAHIVP, discuss considerations for HIV pre-exposure prophylaxis (PrEP) persistence, including: The PrEP continuum of care in the United States, including inequities in PrEP uptake and persistence by race CDC PrEP guidance regarding PrEP indications PrEP eligibility by regimen Summary of renal, bone, and weight outcomes wi...

In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, and Samantha Strong, PharmD, BCACP, AAHIVP, CDCES, answer questions including: Strategies to improve disparities in pre-exposure prophylaxis (PrEP) access in difficult-to-reach populations  Key remaining questions related to PrEP options for cisgender women and people who inject drugs Concerns about resistance at seroconversion in patients with...

In this episode, Maria Buti, MD, and Richard H. Davis, PA-C, address key considerations when screening, diagnosing, and treating patients with hepatitis delta virus (HDV), such as: Barriers to screening  HDV screening based on patient risk factors  Universal screening for all patients with positive hepatitis B surface antigen (HBsAg) Reflex testing  Availability of commercial testing Monitoring su...

In this episode, Latesha Elopre, MD, MSPH, discusses key considerations to barriers to PrEP uptake, including: Addressing disparities among racial and ethnic minority populations Understanding the concept of intersectionality  Tackling multiple levels of intersectionality Individual (eg, self-stigma, mental health) Network (eg, access to PrEP services) Community (eg, racism, stigma, poverty) Socia...

In this episode, Darcey Wooten, MD, discusses updated guidance and rationale for monitoring for new HIV infections in people receiving long-acting PrEP, including: Testing both Ag/Ab and HIV-1 RNA Steps to take when a person receiving long-acting PrEP develops a new HIV infection Presenter: Darcy Wooten, MD Associate Professor of Medicine Division of Infectious Diseases and Global Public Health De...

In this episode, Darcey Wooten, MD, discusses the long-acting HIV treatment agent lenacapavir for treatment-experienced people with HIV, including: Efficacy data Initiation strategies Virologic failure data Safety information Presenter: Darcy Wooten, MD Associate Professor of Medicine Division of Infectious Diseases and Global Public Health Department of Medicine University of California, San Dieg...

In this episode, Nancy Reau, MD, and Lydia Tang, MBChB, discuss how to increase linkage to care rates for persons with hepatitis D virus, including: Updates on currently low rates of linkage to care Barriers preventing patients with HBV/HDV  coinfection from engaging in care Interventions to increase retention in care for patients with HDV   Faculty:  Nancy Reau, MD Professor of Medicine Chief , S...

In this episode, Coleman I. Smith, MD, and Lydia Tang, MBChB, discuss how to screen for hepatitis delta virus (HDV), including: Algorithm for evaluation of HDV Diagnosis of different stages of HDV infection  Strategies to increase HDV testing rates  Faculty: Coleman I. Smith, MD Professor of Medicine Hepatologist Georgetown Transplant Institute Georgetown University Washington, DC Lydia Tang, MBCh...

In this episode, Jill Blumenthal, MD, MAS, and William R. Short, MD, MPH, AAHIVS, address key considerations when evaluating ART safety and tolerability in pregnant people, those trying to conceive, and transgender individuals, such as: Approaching patients trying to conceive on nonpreferred ART regimens (eg, 2-drug regimens like LA CAB and RPV) Optimizing the use of the Antiretroviral Pregnancy R...

In this episode, 2 HIV experts from Latin America share their thoughts on the current status of HIV prevention strategies in the region, including recent successes and ongoing challenges. Specifically, the faculty discuss: Barriers that limit PrEP availability in many regions of Latin America despite the high need among vulnerable and at-risk groups Successful expansion of PrEP access in Brazil Ke...

In this episode, Canadian HIV experts share their thoughts on some of the most important new insights from HIV treatment and prevention research over the past year. Specifically, the faculty discuss treatment strategies for patients with a history of NRTI resistance based on findings from the 2SD and NADIA trials; the latest data informing the use of 2-drug oral and injectable treatment regimens;...