CorConsult Rx: Evidence-Based Medicine and Pharmacy

On this episode, we review the data for tirzepatide, a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist that is under development for the treatment of type 2 diabetes a new medication that is being investigated. We discuss the unique mechanism of action and summarize the data from the SURPASS studies.  Thanks for listening! If you want to suppo...

On this episode, we review medication regimens for special patient populations. We start with a quick overview of CYP450 drug-drug interactions. We then discuss safety conerns when starting medications in a patient that is pregnant, is at an increase risk for a bleed, renal impairment, and hepatic impairment. Once again, we're excited to announce that our listeners can claim ACPE-accredited contin...

On this episode, we discuss some of the basics of treating a patient with hepatitis C. We list the labs that should be drawn prior to starting treatment as well as non-invasive ways of assessing fibrosis/cirrhosis. We also review some information about the pangenotypic medications, Epclusa and Mavyret.  Click the following link to see the upcoming events from the Southeast Viral Hepatitis Interact...

On this episode, Cole and I are joined by Trevor Walker, PharmD Candidate 2022. We begin by comparing and contrasting the original SSRIs as well as new agents like vortioxetine and vilazodone. We then review some serotonin (5-HT) receptors and how their activity (or inhibition) determine and mitigate outcomes and adverse effects. We close by reviewing the ANTLER trial that was published in NEJM in...

On this episode, we discuss the management of endometriosis. We begin with some background information including risk factors, sign and symptoms, and more. Then we review the common first-line agents used, sometimes even before a definitive diagnosis via laparoscopy. We then compare and contrast more specialized treatment options including gonadotropin-releasing hormone agonists with add-back ther...

On this episode, we review the 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults published by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).  Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacothe...

On this episode, we are joined by the host of the Pharm So Hard podcast, Dr. Jimmy Pruitt, PharmD, BCPS, BCCCP, to discuss the 2021 Surviving Sepsis Campaign Guidelines. The guidelines can be found at the Society of Critical Care Medicine's website: SCCM Sepsis Guidelines For more critical care educational content, make sure you check out Dr. Pruitt's new website: Acute Care University Follow the...

On this episode, we discuss the prevention and acute management of migraines. We start by reviewing the pathophysiology associated with a migraine. We then compare and contrast various pharmacological classes utilized in migraine prophylaxis as well as acute relief of symptoms.  Once again, we are excited to announce that listeners can claim ACPE-accredited continuing education for this episode! W...

On this episode, we are joined by Dr. Spencer Carter, MD and Dr. Kyle Fischer, PharmD, to discuss preserved ejection fraction heart failure. Dr. Carter is a cardiologist finishing his fellowship that is focused on heart failure and cardiac transplant.  Dr. Fischer is currently a PGY1 general clinical pharmacy resident. We begin by discussing some background information including pathophysiology an...

On this episode, we review the pharmacotherapy options for managing Parkinson's disease. We begin with some background pathophysiology/etiology. Then, we compare and contrast the various medication options available.  Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as down...

On this episode we are joined by MUSC P4, Calynn Dioses, to discuss medications that help patients with their weight loss goals.  Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable Power Point slides for each lecture. You can find our account at the website be...

On this episode, we discuss the use of hormone therapy in perimenopausal/menopausal women. We give some background information as well as labs that should be monitored. We then separate the therapy options based on whether the patient is experiencing vasomotor symptoms, vulvovaginal symptoms, or a combination of both. We close by reviewing the results of the Women's Health Initiative (WHI) study. ...

On this episode, we discuss the management of rheumatoid arthritis. We start by reviewing some background information. Then, we compare and contrast the various medications options including DMARDs, TNF-alpha biologics, and non-TNF-alpha biologics.  Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmaco...

On this episode, we are joined by 4th year, MUSC students, Shannon Himes and Blake Adams. We discuss a patient case that involves HFpEF (with uncontrolled hypertension), type-2 diabetes, stage 2 chronic kidney disease, and benign prostatic hyperplasia.  Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new phar...

On this episode, we discuss immunologically mediated adverse reactions that patients can have to foods (food allergies). We provide a brief overview of some background information and pathophysiology. We then review the pharmacological management of an acute allergic reaction and close with some noteworthy information about the drug, Palforzia (peanut allergen extract).  Thanks for listening! If y...

On this episode, we are joined by PGY1 resident, Dr. Kristen Ingold, PharmD. Kristen came on the show to discuss her series of training videos designed to help students prep for their residency/fellowship interviews. She virtually interviewed 20-25 residency program directors (RPDs) from across the United States. Each RPD was asked the same list of questions. After collecting all of the interview...

On this episode, we discuss the latest pharmacotherapy recommendations for asthma management based on the 2021 GINA guidelines. We review the various medication options as well as compare and contrast the different options for rescue/maintenance therapies. We also discuss the use of biologics in patients with worsening asthma and evidence of type-2 inflammation.  Once again, we're partnering with...

On this episode, we compare and contrast the various formulations of hormonal contraceptive options. We discuss some clinical pearls that are important for selecting the best option based on a patient's specific comorbidities and symptoms during her menstrual  cycle. We then provide some examples of cormorbidities and explain the process for selecting a hormonal contraception product that will wor...

On this episode, we discuss medication safety during pregnancy. We start by listing common teratogens to watch for in patients that are currently pregnant or trying to become pregnant. We then review the preferred treatment options for common disease states in patients that are currently pregnant. The list of common pregnancy/lactation references we mentioned is below: Briggs' Drugs in Pregnancy a...

On this episode, we revisit the topic of managing acute coronary syndrome. We review some background information and differentiate between a STEMI, NSTEMI, and unstable angina. We then review the inpatient treatment algorithm for each. We close by discussing the follow up including the length of dual anti-platelet therapy.  Thanks for listening! If you want to support the podcast, check out our Pa...

On this episode, we are joined by MUSC forth year PharmD student, Matthew Brock.  We review a patient case that covers multiple co-morbidities. We start by discussing the patient's COPD management and the recommendations from the 2021 GOLD guidelines. We then review low dose rivaroxaban with lose dose aspirin in patients with PAD. Then, we talk about strategies for managing his angina and hyperten...

On this episode, we do a deep dive into hypertension management. We discuss the various medication classes, and then go into the pharmacotherapy algorithm.  Once again we're excited to partner with freeCE for our listeners claim ACPE-accredited continuing education for this episode! Listeners will have the opportunity to claim 1 hour of home-study continuing education credit by visiting the follow...

On this episode, we are joined by Dr. Swathi Varanasi to review adaptogens, nutraceuticals, Ayurveda, and other elements of Integrative Health. We also discuss the upcoming webinar series called Integrative Health 101 that she developed along side Integrative Health expert, Dr. Pam Tarlow. More information about the upcoming webinar is below:   https://www.doctorswathi.com/integrative-health-101/...

On this episode, we discuss treating community-acquired pneumonia. We start with the outpatient treatment options based on the 2019 IDSA CAP guidelines. We also discuss managing a patient that has been admitted. We review some reasons to use more broad-spectrum empiric therapy, and close by mentioning the new Prevnar 20 vaccine.  We want to thank the sponsor of this episode, Pyrls. Pyrls is a new...