CorConsult Rx: Evidence-Based Medicine and Pharmacy

On this episode, we compare and contrast the various pharmacotherapy options used to manage acne vulgaris. We review topical retinoids, topical and oral antibiotics, androgen-receptor inhibitors, oral contraceptives, spironolactone, and oral isotretinoin. We close with a patient case to summarize the episode.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing ed...

On this episode, we discuss the management of ulcerative colitis and review the various pharmacotherapy options that are currently available.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing educa...

On this episode, we are joined by Dr. Will Flanary (AKA Dr. Glaucomflecken) and Kristin Flanary (AKA Lady Glaucomflecken). Dr. Flanary is a practicing ophthalmology who also creates hilarious skits incorporating a wide range of characters who worked at a fictional hospital called "Glaucomflecken General." As Dr. Glaucomflecken, he has collaborated with the US Surgeon General, given the 2022 Yale M...

On this episode, we review the pharmacotherapy options available for managing primary-open angle glaucoma. We discuss prostaglandin analogs, beta-blockers, alpha-2 agonists, carbonic anhydrase inhibitors, cholinergics, rho kinase inhibitor, and more. We also briefly review angle-closure glaucoma to finish the episode.  Cole and I are happy to share that our listeners can claim ACPE-accredited cont...

On this episode, we discuss the management and treatment of irritable bowel syndrome (IBS). We review the various medications recommended published in the 2020 American College of Gastroenterology and the 2022 American Gastroenterological Association treatment guidelines. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast e...

On this episode, we review the recently published CLEAR-outcomes trial that was looking at bempedoic acid's (Nexletol) ability to lower the risk of CV events in patients who were unable to tolerate statins at their recommended doses. While recording this episode, we used the trial summary written by Dr. Alex Poppen, PharmD who is the author/owner of the book High-Powered Medicine: Landmark Clinica...

On this episode, we review the treatment and management of various types of anemia. We discuss iron-deficiency anemia, B-12 and folate dificiency anemia, anemia due to CKD, anemia due to chronic disease (inflammation), and aplastic anemia.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to par...

On this episode we cover three different topics that have been in the medical news lately. First, we compare/contrast the blood pressure goals that were published by the American College of Physicians with other prominent hypertension guidelines. Second, we discuss the semaglutide "side effect" that has been coined Ozempic Face. Finally, Cole reviews some literature surrounding the health benefits...

On this episode we review typical (first generation) and atypical (second generation) antipsychotics. We discuss receptor signaling, various adverse effects, and specific clinical pearls for the individual medications in the antipsychotic class.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued...

On this episode, we discuss dosing antihypertensives at bedtime compared to the morning and if it impacts patient outcomes. We review the MAPEC, Hygia, and TIME studies as well as other editorials on this debated topic. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com...

On this episode we discuss the new drugs that have been approved in 2023 so far. We review Leqembi (lecanemab-irmb) injection for Alzheimer's disease, Airsupra (albuterol and budesonide) inhalation for as-needed use in asthma, and Brenzavvy (bexagliflozin) for type 2 diabetes. We also mention Rykindo (risperidone) ER injection, but we didn't go into much detail since we've gone over risperidone in...

On this episode, we discuss the pharmacotherapy options for managing obsessive compulsive disorder (OCD). We based our discussion on the treatment algorithm created by Dr David Osser. All of Dr. Osser's work with the Psychopharmacology Algorithms Project at the Harvard South Shore Psychiatry Residency Training Program can be found at the following website: https://psychopharm.mobi/algo_live/# Cole...

On this episode, Cole and I review some of the updates that were published in the 2023 American Diabetes Association guidelines. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit fo...

Below is the patient case information: 63-year-old white male. Problem List Bipolar II disorder Insomnia Epilepsy (tonic-clonic seizures) Dyslipidemia/hypertriglyceridemia Hypertension Recent weight gain History of hyponatremia   Diabetes type 2(controlled) Medications Clonazepam 2 mg QHS Risperdal 2 mg twice daily Carbamazepine 200 mg twice daily Divalproex DR 500 mg three times daily Levetiracet...

On this episode, we discuss the management of insomnia disorder. We review the criteria necessary for an insomnia disorder diagnosis. We then compare and contrast the pharmacotherapy options such as non-benzodiazepine hypnotics, benzodiazepines, anti-depressants, orexin receptor antagonists, and more.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education...

On this episode, we discuss the various therapeutic options for managing a patient with chronic pain. We discuss nonpharmacological options, anti-inflammatory medications, and other non-opioid pharmacological options. Then, we compare and contrast some of the commonly used opioids and discuss some of the nuances/clinical pearls for individual opioids. Cole and I are happy to share that our listene...

On this episode, Cole and I review the published treatment algorithm created by Harmony Raylen Abejuela, MD and David Osser, MD. This was part of the Psychopharmacology Algorithm Project at the Harvard South Shore Program. A link to the article on Pubmed is below: Anxiety Algorithm Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this...

On this episode, we review the results that have been reported from the Diuretic Comparison Project (DCP). The point-of-care clinical trial was looking at CV outcomes based on patients using HCTZ vs chlorthalidone. We also discuss the reasons for using indapamide over other thiazide (like) diuretics.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug...

On this episode, we compare and contrast oral medications that can be used to manage patients with type-2 diabetes. We review metformin, SGLT2 inhibitors, oral semaglutide, sulfonylureas, TZDs, and more.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide list...

On this episode, we review the management of amyotrophic lateral sclerosis (ALS). We discuss riluzole, edaravone, and sodium phenylbutyrate-taurursodiol (Relyvrio) that gained FDA approval in September 2022.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If...

On this episode, we discuss chronic coronary syndromes, and we focus primarily on the treatment of acute episodes of angina.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have continued to partner with freeCE.com to provide listeners with the opportunity to claim 1-hour of continuing education credit for s...

On this episode, we discuss the management of acute and chronic atrial fibrillation. We review the various pharmacotherapy options, compare rate control versus rhythm control, and discuss other clinic trials that support the newest treatment guidelines.  Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast episode! We have co...

We are joined by Dr. Wayne Weart to celebrate reaching our 200th episode. We discuss his career as a clinical pharmacist and educator and get his thoughts on the current state of the pharmacotherapy world.  Thanks for listening! We want to give a big thanks to our main sponsor Pyrls. Try out their drug information app today. Visit the website below for a free trial: www.pyrls.com/corconsultrx If y...

On this episode, we review the data that lead to some SGLT-2 inhibitors being used routinely in heart failure. We discuss the initial cardiovascular safety studies that initially showed heart failure benefit in this class. Then we look as some of the newer studies that have looked at empagliflozin and dapagliflozin in heart failure patients (with and without diabetes as a comorbidity). Cole and I...

On this episode, we discuss deucravacitinib tablets (Sotyktu), roflumilast cream (Zoryve), and tapinarof cream (Vtama). All three medications were approved in 2022 and represent new classes of medication for the treatment of plaque psoriasis. We also give a brief overview of the older treatment options that are used for plaque psoriasis as well.  Thanks for listening! We want to give a big thanks...