Bryan Johnson Podcast

Should I try shrooms for science? In part two of three of our series investigating drugs for longevity, I’m putting psilocybin, LSD and DMT under the microscope - and revealing some pretty exciting research that connects psychedelics to longer lifespans. We’ll also talk about weed, and what the data says about marijuana for longevity.   Study Links: Psilocybin for Cancer Patients   LSD: Longevity...

Can doing lines help you live longer? That depends on what you’re taking. In this three-part series, I’m ranking drugs based on their ties to longevity, starting with ketamine and cocaine. I tested ketamine on myself to study its impacts on the brain — here’s what we found.   Study Links: Ketamine’s Effects on Epigenetic Age  Extending Ketamine’s Therapeutic Window Ibogaine Therapy for PTSD  Hosts...

Fitness creator Jesse James West is a natural bodybuilder who makes some of the coolest videos on YouTube for over 7 million subscribers. We’re talking about his motto of “stay relentless,” and how he balances work, health and life now that he’s newly married. Plus, he shares about the time that he also had a breakdown in Target - and how it may have saved his life. Connect with Bryan:  X: https:/...

Between synthetic dyes, air pollution, and environmental toxins, kids have a lot of obstacles in the way of their health. I’m reviewing some top offenders (like synthetic dyes and added sugars) and discussing how to empower our kids to make informed choices.  Study Links:  Synthetic Dyes in Food & Beverages HEPA Filters in LA Schools US Kids Face Deadlier Odds Peanut Allergies & Air Pollution Host...

My team and I looked into the biological effects of eating a*s and choking during sex - here’s what we found. I’m also sharing why I monitor my erections - and why this metric is critical for good health and longevity.  Study Links:  Choking During Sex  Overnight Erections Female Erection Cycles  Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint Co-Founder Dr. Mike Mallin: Lead Physicia...

Had I protected my body and brain, I’d be wealthier and more successful today. Culture is lying to you — you do not need to martyr yourself to be successful. Here’s how you can avoid making the same mistake I did. Study Links:  Burnout + Heart Attack Risk  Hours Worked + Heart Disease Sleep Deprivation in CEOs Sleep Deprivation in Judges Hosts: Bryan Johnson: Blueprint Founder Kate Tolo: Blueprint...

Society is bathing us in chemicals. From wildfires to 4th of July fireworks, toxins feel inescapable. Here’s what I’m doing to limit exposure and reduce my levels. Show Links:   Blueprint Food Guide: https://blueprint.bryanjohnson.com/pages/blueprint-protocol#food-guide Further Listening:  “How Sauna Detoxified My Body” - Bryan Johnson Podcast  “We Need to Talk About Microplastics” - Bryan Johnson...

International travel is brutal on your mind, body, and sleep. We discuss the recent data and I share my current jet lag protocol (still evolving) to help minimize the damage after long flights. Study Links:  Olympic Athletes + Jet Lag: https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.998484/full Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com...

Microplastics are everywhere — even in glass bottles. Should you be worried? Kate, Mike, and I interpret the data to understand the risk. I’ll share how I reduced my own levels by 93% so you can too.   Study Links:  Glass Bottle Study: https://www.sciencedirect.com/science/article/pii/S0889157525005344 Impact on Children: https://www.nejm.org/doi/abs/10.1056/NEJMms2409092 Connect:  X: https://x.co...

Quality sleep is the highest-return investment I’ve ever made. In this episode we walk you through my exact protocol, so you can cherry-pick what works, experiment, and track gains for yourself.  Study Links:  https://pmc.ncbi.nlm.nih.gov/articles/PMC3902870/ Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjohnson  ...

At last, we tested sauna for longevity. I’m dropping my sauna protocol and explaining why they are definitely worth the hype. Plus, hear about my first time ever stepping into one, and why it was one of the most difficult — but rewarding — protocols I’ve ever done. Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjoh...

Dr. Mike Israetel is back. We’re talking about deep work, sharing a brain with AI, strategies for creativity, and how money and fame changed our lives, for better and worse. About Dr. Mike:  Dr. Mike Israetel is an expert in the field of fitness and performance. He’s served as a professor at Lehman College, Temple University, and the University of Central Missouri, teaching exercise science course...

I’ve become the worlds healthiest human. Today I’m sharing more on my longevity protocols and biomarker testing and why that’s an essential piece of the Don’t Die movement. We’re also getting into sperm health and why it’s important to keep your testicles cool.  Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjohnso...

If you’re worried about “dad bod,” listen up. We’re discussing a new study among mice. We review the new data behind dad bod and how you can prevent it. We also dive into bone health and why you should care, and the healthiest way to get your protein.    Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjohnson   TikT...

Is it better to work out at night or in the morning? A new WHOOP study covers new data on evening exercise. Kate, Mike and I also share why lowering your resting heart rate (RHR) may be one of the most powerful strategies for longevity and overall health.  WHOOP Study: https://www.nature.com/articles/s41467-025-58271-x Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@Brya...

There’s a new treatment for longevity — one you probably haven’t heard of before. I review my experiments with hyperbaric oxygen therapy (HBOT) and how it dramatically transformed my biomarkers. We’ll also cover the ways air pollution shows up in your body, something I experienced firsthand while traveling in India.   Links and Studies  Analyzing India’s Air Quality: https://x.com/bryan_johnson/st...

What’s the truth when it comes to creatine? And which sleep tracker gets you the best results? Blueprint co-founder Kate Tolo and Blueprint Chief Medical Officer Dr. Mike Mallin join me to discuss the science behind some of the hottest wellness topics to find out which ones are actually worth your time.   UNSW Creatine study: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatine...

The Bryan Johnson Podcast is ushering in a new era of being human. In this podcast I am joined by longevity physician Dr. Mike Mallin, my co-founder Kate Tolo, and the occasional guest. We discuss the science-based protocol to help you become your best self. Join us on this journey. New episodes releasing weekly.

Just how bad is Trevor Wallace’s comedy career for his body? Comedian and host of the podcast “Stiff Socks” talks about his life on the road. I offer Trevor some practical tips to help him look and feel his best.  Connect:  X: https://x.com/bryan_johnson YouTube: https://www.youtube.com/@BryanJohnson Instagram:  https://www.instagram.com/bryanjohnson   TikTok:  https://www.tiktok.com/@_bryan_johns...

Fitness expert Dr. Mike Israetel shares his take on artificial intelligence, what to consider before trying steroids, and his experience dealing with haters. Dr. Mike Israetel is an expert in the field of fitness and performance. He’s served as a professor at Lehman College, Temple University, and the University of Central Missouri, teaching exercise science courses focusing on nutrition, strength...