Authentic Biochemistry

Oncotarget. 2013 Oct; 4(10): 1552–1553

In this episode Dr. Guerra provides the overview of Pharmacodynamics .

A.D.M.E. Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492. Please subscribe and donate! Dr. Guerra needs your support!

Risk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization. The immune  response becomes compromised during aging leading to states of hyperinflammation followed by hypo-immune sequalae opening up the potential for opportunistic respiratory infections and alterations in pulmonary endothelial membrane lipid fluidity restrict...

Seminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126 Pharmaceutical Research March 2018, 35:49 Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182 J. Lipid Res. 2018 59:(3) 488-506.

Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020 Molecular Neurodegeneration volume 7, Article number: 45 (2012) J Biol Chem. 2019 Jun 7;294(23):9213-9224

Annu. Rev. Physiol. 2013. 75:685–705 Nutrients. 2020 Mar; 12(3): 622

FASEB J. 2013 Jun; 27(6): 2458–2467. Scientific Reports volume 7, Article number: 13763 (2017)

Scientific Reports volume 9, Article number: 1220 (2019) Prog Neuropsychopharmacol Biol Psychiatry . 2005 Oct 12 Bulletin of Experimental Biology and Medicine .2003. 136.(3). 1573-8221  Pharmacological reports 2005, vol. 57, no6, pp. 811-817 Brain Res Bull, December 11, 2006; 71(1-3): 279-86. Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997) Scientific Reports volume 7, Article num...

Brain Behav Immun. 2019 Oct;81:41-51 Neuroimmunomodulation 2002/2003;10:101-121 Front. Neurol., 23 January 2018

TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling. TLR  interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's. J Neuroinflammation. 2014 Sep 20;11:166 Brain Behav Immun....

Pathogens, and abiotic ischaemic damage manifest a constellation of  molecular interactions triggering pattern recognition receptors such as TLR's, with canonical protein binding domains that signal through intracellular cascades such as activating  Ca2+ signaling; eo ipso obtaining potent hyperimmune inflammation,  providing  event ontological foundation and episodic contribut...

Oncotarget. 2016 Jan 26; 7(4): 4195–4209 Nature Reviews Immunology volume 6 , pages644–658(2006)

The removal of damaged neurons and associated synaptic connections with the simultaneous repair of other neuronal circuits is a mechanism for the sculpting of the brain network and thus a means by which the highly innervated and connected prefrontal cortex can receive and respond to neurotransmission from the limbic system. Reference: Genes (Basel). 2019 Mar; 10(3): 249

Authentic Biochemistry Podcast 27 April 2021 References Clin Diagn Lab Immunol. 2003 Jan;10(1):13-8 J Exp Med (2012) 209 (1): 187–199. Cell Reports 2020. V 30, (Issue 5) :1585-1597.e6

References Experimental & Molecular Medicine volume51, Article number: 80 (2019) Am J Nephrol.2017;46(5):371-379 EMBO Rep . 2003 Aug;4(8):774-80 J Biol Chem. 2020 Jul 3;295(27):9052-9060 Mol Immunol. 2017Aug;88:125-134

As an hypothetico-deduction,  Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity. In conjunction with a neutral sphingomyelinase and the subsequent synthesis of diacylglycerol thence promoting activation of a PKC-Zeta, T cell receptor translocation and activation are obtained.  Prior RAG mediated recombination events...

Single-nucleotide polymorphisms and  copy-number variations (CNV’s)  result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in  the accumulation of chromosomal variation. Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene p...

Neuroinflammatory mediators play a critical role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. These processes occur throughout life and involve the immune system, biochemical pathways, cellular turnover and alteration of gene expression. Signal transduction cascades allow for genome...

An Introduction to the theory of immunoepigenetic tailoring of human instanence. Dr. Guerra Authentic Biochemistry Podcast Studios

J Immunol August 1, 2017, 199 (3) 874-884 Ann Rev Cell Dev Biol 2018. 34:111-136 Blood. 2016 Apr 14;127(15):1930-9 J BiolChem. 2017 Aug 25; 292(34): 14292–14307

What is involved to make a sound decision? Biochemistry is a scientific discipline; one that examines and interprets the foundational structures and functions of living systems. As with any judgment, as there are reasons for believing, there are also reasons for disbelieving, and the freely willed decision to choose which, should involve the discovery of truths to use as exemplars for seeking cohe...

Annual Review of Cell and Developmental Biology Vol. 34:111-136 Journal of Neuroscience 23 October 2019, 39 (43) 8576-8583 Archivum Immunologiae et Therapiae Experimentalis 2013 Apr;61(2):119-25.

 In this foundational lipid absorption lecture,  Dr. Guerra address the roles of apo- lipoproteins, triacylglycerol and cholesteryl esters with membrane associated caveolae transport in adipocytes, endothelia and skeletal muscle. An Authentic Biochemistry Podcast Production. 25 March 2021.

Electron transport and the anapleurotics of intermediary metabolism. Dr. Daniel J. Guerra Authentic Biochemistry Studios 21.3.21