Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1334 episodes

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Author

Dr Daniel J. Guerra

Episodes

Diabetes XXXIV. White vs brown adipocytes and the role of transcription factors and metabolic enzyme expression to mediate bioenergetics vs.lipogenesis in store depot fat.DJGPhD.17.4.22. Authentic B. 18.04.2022 30:00

References Dr. Guerra's lipid lecture archives PNAS July 24, 2017 | 114 (32) 8649-8654 Int J Mol Sci. 2019 Oct; 20(19): 4924

Diabetes XXXIII. Synthesis of lecture arc Part 2. Dr Daniel J. Guerra. Authentic Biochemistry Podcast Studios. 16.4.22 16.04.2022 29:58

References Dr. Guerra's notes

Diabetes XXXII. Fatty acid oxygenation and use of eicosanoid molecular species to regulate T2D-linked inflammation via the agonization of the nuclear receptor transcription factor PPAR.DJGPhD 15.4.22 15.04.2022 29:59

References Dr Guerra lipid lecture notes Biophysical J. Volume 110, Issue 11, 7 June 2016, Pages 2397-2406 Am J Pathol. 2020 Sep; 190(9): 1782–1788

Diabetes XXXI. REDOX biochemistry mini-review and the roles of essential fatty acid elongation/desaturation metabolism and COX/LOX oxygenation as ligands for PPAR isoforms in T2D pharmacotherapy. 14.04.2022 29:55

References Dr. Guerra lecture material Nutr J. 2014; 13: 17.

Diabetes XXX. The pleitropic roles of free fatty acids and PPAR's as mediating insulin sensitivity, intermediary metabolism and the inflammatory response in T2D.Dr Daniel J. Guerra 13.4.22. Authentic 13.04.2022 29:45

References Dr. Guerra lecture notes Prog Neurobiol. 2018 Apr-May; 163-164: 27–58. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:28–40

DiabetesXXIX. THe CNS axis of Obesity-linked T2D via alterations in PPAR transcription factor mediated expression of ameliorative hippocampal AMPAR and LTP neural transmission in Alzheimer's Discsease 12.04.2022 29:37

References Dr. Guerra's Lecture Notes Journal of the American College of Nutrition. 2019. 38:8, 693-702. Curr Diabetes Rev. 2020;16(8):797-806

Diabetes XXVIII. Diabetic nephropathy is a consequence of non-esterified free fatty acid associated ceramide induction of the IRS-1 phosphorylation in glomerular podocytes inducing inflammation 08.04.2022 30:00

References Dr Guerra lecture notes Front. Endocrinol., 14 October 2014. Sci Rep. 2020; 10: 21628.

Diabetes XXVII. Dyslipidaemia and the Insulin Resistance Axis. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast 7April2022. 07.04.2022 29:28

References Dr. Guerra's lectures Curr Med Chem. 2017;24(17):1827-1852 Cancer Res. 2018 Apr 1; 78(7): 1713–1725

Diabetes XXVI. Adipogenic and hypertrophic adiposity differentially control dyslipidaemia and Insulin resistance in association with pro-inflammatory cytokine induced T2D and breast cancer.DJGPhD. 05.04.2022 29:55

References Dr. Guerra's lipid lecture notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725. Progress in Lipid Research Volume 74, April 2019, Pages 145-159

Diabetes XXIV. Sphingosine 1-phosphate targeting and the abalation of primary breast cancer metastasis: IL6 mediated tumorigenesis blockade? Dr Daniel J. Guerra 01April2022. Authentic Bbiochemistry 02.04.2022 29:53

References Dr Guerra's notes Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042

Diabetes XXIII. Obesity-associated IL6 and sphingosine 1-phosphate are linked to breast cancer.Dr. Daniel J. Guerra. 31 March 2022. Authentic Biochemstry 01.04.2022 29:50

References Dr. Guerra's  lecture notes Front. Physiol., 30 January 2019 | https://doi.org/10.3389/fphys.2019.00042 Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.

Diabetes XXII. Obesity and cancer are linked by inflammation and dyslipidaemia. Dr Daniel J. Guerra. 30.3.22 Authentic Biochemistry 31.03.2022 29:41

References Dr Guerra's lectures notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725 Cold Spring Harb PerspectBiol. 2018 Feb; 10(2): a028415.

Diabetes XXI. TAG accumulation in skeletal muscle of diabetics vs athletes and suggested role of Intramuscular TAG in Insulin Resistance due to subcelluar localization of lipid droplets. DJGPhD.27.3 28.03.2022 29:30

References Dr Guerra's lecture notes Diabetologia. 2021 Jan; 64(1): 168–180 Diabetologia. 2020 Dec;63(12):2654-2664

Diabetes XX. Intermediary metabolic allosteric regulation in the Myocardial Infarcted heart reveals HF aetiology from obesity-linked Type 2 Diabetes. DJGPhD.25.3.22. Authentic Biochemistry Production 25.03.2022 29:50

References Dr. Guerra lecture notes J AM Coll Cardiology Basic Trans Science.2019. (4) 3: 385-400

Diabetes XIX. THe ketogenesis bioenergetic system can be corrupted via DAG-kinase mediated pyroptosis in the obese/T2D CNS. Dr. Dan Guerra. 22.3.22. Authentic Biochemistry Podcast 22.03.2022 29:53

References Dr. Guerra lecture notes Circulation Research Volume 128, Issue 10, 14 May 2021; Pages 1419-1420 Adv Exp Med Biol . 2017;960:135-160. Current Opinion in Clinical Nutrition and Metabolic Care Issue: Volume 21(4), July 2018, p 260-266

Diabetes XVIII. Myokine mediated muscle mass signaling is corrupted by obesity linked Type 2 diabetes via massive inflammation and dyslipidaemia.DJGPhD. 21.3.22. Authentic Biochemistry 21.03.2022 29:34

References Dr. Guerra's lecture notes J Immunol. 2018 Nov 15;201(10):2934-2946 Endocr Rev. 2020 Aug; 41(4): 594–609.

Diabetes XVII. Short and medium chain fatty acid derived ketones and skeletal muscle Myokines to improve cognitive and homeostatic well-being in humans. DJGPhD. 20.3.22 Authentic Biochemistry. 21.03.2022 29:38

References Dr Guerra lecture notes Endocr Rev. 2020 Aug; 41(4): 594–609 Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) 2021 Volume7, Issue1 e12217

Diabetes XVI. Fornix white matter fascicular region of the hippocampus nuclei is spared from neurodegeneration by dietary medium chain saturated fatty acid. DJGPhD.Authentic Biochemistry19.3.22 19.03.2022 29:02

References Dr Guerra's Lecture notes Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) Volume7, Issue1 2021 e12217

Diabetes XIV. The Neuropsychiatric/Neurodegeneration axis from Sphingomyelin Degeneration to Increased Inflammation. Dr. Daniel J. Guerra. 17.3.22. Authentic Biochemistry Productions 17.03.2022 29:53

References Dr Guerra Lecture archives Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI) 2021.Volume7, Issue1 e12217 EBioMedicine. 2015 Dec; 2(12): 1888–1904

Diabetes XII. Free fatty acid dyslipidaemia associated dysregulation of hepatic and skeletal muscle Insulin Receptor Substrate (IRS)1/2 axis. Dr. Daniel J. Guerra15.3.22. Authentic Biochemistry . 16.03.2022 29:45

References Dr. Guerra's lecture notes Curr Med Chem. 2017;24(17):1827-1852 Journal of Hepatology 2012 56, 704-713DOI: (10.1016/j.jhep.2011.09.020)

Diabetes XI. Biometrics in research interpretation. Dr Dan Guerra 14.3.22 Authentic Biochemistry. 14.03.2022 29:42

Reference George A, Stead T S, Ganti L (August 26, 2020) What’s the Risk: Differentiating Risk Ratios, Odds Ratios, and Hazard Ratios?. Cureus12(8): e10047. doi:10.7759/cureus.10047.

Diabetes IX. The role of peroxisomes in ether-linked lipid biosynthesis. Dr.Daniel J. Guerra. 07March2022. Authentic Biochemistry Podcast production 08.03.2022 29:57

References Dr Guerra's lecture material

DiabetesVIII. Subcellular organization and the role of lipid metabolism in mitochondria and peroxisomes. Dr Daniel J. Guerra. 05March22. Authentic Biochemistry 05.03.2022 30:00

From Dr. Guerra's lecture archives

Diabetes VII. Cholangiocarcinomas and the corruption of the biliary system as sequalae of obesity and associated pancreatic exocrine insufficiency of diabetes. Dr Dan Guerra. 3.March.2022. A.B. 04.03.2022 29:48

References Dr Guerra's lecture notes World J Gastroenterol. 2013 Nov 14; 19(42): 7258–7266. Int J Endocrinol. 2015; 2015: 595649. PLoS One. 2017; 12(10): e0186643. BMC Cancer. 2019; 19: 185

Diabetes V . PEI and Diabetic Dyslipidaemia with Primary Cholagiocarcinoma. Primer on lipid digestion and Lipoprotein Trafficking. Dr. Dan Guerra. Authentic Biochemistry 01.March.2022 02.03.2022 30:00

References Dr. Guerra lecture notes BMC Cancer. 2019; 19: 185.