Authentic Biochemistry

Pro-inflammatory gene transcription is tanked when demethylation is inhibited but cytotoxicity of  virally infected or cancer cells by NK’s (where demethylation is inhibited) remains intact. References J. Biol. Chem. 2018;293:2422-2437 J. of Biol. Chem. 2016. 291, 23756-23768

Dr. Guerra discusses some of the complexity of both the epigenetic mechanisms and cellular responses associated with immunomodulatory failure  in the aging human. References  Anal Cell Pathol (Amst). 2018; 2018: 787.1814. Daniel J. Guerra. 2018. DOI: 10.5772/intechopen.82176  https://www.intechopen.com/chapters/64596

Dr. Guerra continues a dialectical accounting of the biochemical and cellular events leading to the terminal outcome of aging. Topic today is the reintroduction of Natural Killer Cells and the epigenetic mechanisms that orchestrate unique gene expression.  References Anal Cell Pathol (Amst). 2018; 2018: 787.1814. The Journal of Biological Chemistry2018. 293: 2422-2437

Oxidases, dehydrogenases and oxygenases in the electron transport chain et al.

This is the link to my new (second in the series) of synoptic Human Aging YouTube lectures. https://youtu.be/IckyMGw8Ffs Please subscribe to both my podcast and YouTube channels! And please contribute! It is the First day of Autumn. Enjoy!

Interferons are innate immune agents of inflammation and recovery. Mutations or epigenetic modifications associated with advanced aging may corrupt interferon pathway  fidelity involving mitophagy leading to autoimmune disease and morbidity later in life. References Nat Immunol. 2021 Mar; 22(3): 312–321 J Neuroinflammation. 2019; 16: 236.

A general audio lecture involving a molecular interactome mediating  the  innate immune response and the control over T and B lymphocyte memory cells resulting in long term potentiation of autoimmune disease during aging.

I discuss the complex  but potent interactions of TLR signaling with plasma membrane protein complexes including  semaphorin cytoplasmic kinase interactions leading to PPAR gamma transcription that fires off CD36 and beta oxidation gene transcription to switch M1 to M2 macrophage polarity thus feedback regulating the pro-inflammatory glycolytic mToRC system dynamics. Aging is associated...

Macrophage polarization and differentiation works in conjunction with CD4+ T lymphocyte differentiation into Th1 and Th2 subclasses and both NK and B cell activities. The aging human loses feedback control over the pro-inflammatory and anti-inflammatory pathways from these classical cellular differentiations contributing to hyperinflammation and/or hypoinflammatory responses ultimately resulting i...

https://youtu.be/4sW-BNVhzrs

Dr. Guerra introduces a primer on membrane biochemistry in preparation for a florid analysis of autophagy and the various forms of programmed cell death linked to the aging human. References Cell Discovery volume 7, Article number: 4 (2021)

Non coding RNA may regulate melanogenesis and in combination with plasma cell producing IgG the nutritional regulation of satiety. Aging results in alterations of this complex system thus resulting in localized melanogenesis and a corruption of the HPA axis. References: Aging (Albany NY). 2021 Jan 31; 13(2): 2700–2726. Stem Cells Int. 2020; 2020: 1047896. First Published online 2020 Jul 8 PNAS. 20...

Components of metabolic sequence toward gluconeogenesis in the human liver.

Dr. Guerra details the glucagon and epinephrine mediated control through Stimulatory G-protein couple adenylate cyclase activating PKA over Hepatic Glycolysis and Gluconeogenesis. 

Utilization of a protein cysteine SH derived thioester intermediate alters the free energy hurdle for the synthesis of 1,3 bis PGA thus allowing for glycolytic ATP and NADH synthesis.

The interaction of glycolysis and lactic acid transport from skeletal muscle to the liver plays a significant role in oxygen uptake, transport and release in association with pulmonary carbon dioxide efflux . Dr. Daniel J. Guerra. An Authentic Biochemistry Production 19.8.21.

Any chronic decrease in the ability for molecular oxygen to bind to circulating Hb will diminish its availability in the Central Nervous System and Skeletal Muscle resulting in the potential for long-term Pathophysiology and Illness. Dr. Dan Guerra Published 11 August 2021. Authentic Biochemistry.

Classical Amino Acid Degradation Biochemistry : Emphasis on pathway interconversions and production of bioactive amines

J Physiol. 2005 563:285-90 Eur J Appl Physiol(2011) 111:2837–2843

Biomedicines. 2020 Aug 6;8(8):277.

Journal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464

Journal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464) Life Sci . 2019 Sep 1;232:116612

This is one of my classical biochemistry introductory lectures on amino acid utilization.

Trends in Immunology Volume 36, Issue 4, 2015, 217–228  Carcinogenesis 2015;36:1180-1192

Clinical and Molecular Allergy volume 15 , Article number: 21 (2017) Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247