Authentic Biochemistry

Membrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic Biochemistry 21.06.2022 29:50 ↓

References Dr Guerra's notes Sci Signal. 2016 Aug 23; 9(442): ra83 Front. Pharmacol., 24 April 2019

CytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022 06.06.2022 29:54 ↓

References Dr Guerra's notes Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:436 JAMA. 2008;299(11):1345-1350

CytoEpigenetics XVIII. Membrane lipid architectonics organized for cell cycle and both nuclear and mitochondrial biochemical mediation of gene expression. Dr. Dan Guerra. 05 June 2022 05.06.2022 20:02 ↓

References Dr Guerra's synthesis of lecture material Histochemistry and Cell Biology volume 145, pages275–286 (2016) Biol Rev Camb PhilosSoc.. 2018 May;93(2):827-844.

CytoEpigenetics XVII. The role of ceramide metabolism in epigenetic and bioenergetic cross talk among multiple subcellular compartments. Dr Dan Guerra. 03June2022 Authentic Biochemistry Podcast 04.06.2022 29:40 ↓

References Dr Guerra's synthesis of lectures Scientific Reports volume 5, Article number: 15292 (2015)

CytoEpigenetics XVI. The Mt DNA replicase and helicase enzymes are epigenetically nuclear encoded and localize to the mitochondrial membrane into lipid rafts containing cholesterol. DJGPhD. 2June2022 02.06.2022 29:50 ↓

References Dr Guerra's lecture sytheses Scientific Reports volume 5, Article number: 15292 (2015)

CytoEpigenetics XV.An AMPK phosphorylation cascade promoting mTOR pro-translational induction of NFkappa-B SASP transcription is modulated by NAD+ Sirtuin and PARP during Chromatin retailoring.DJGPhD 28.05.2022 29:59 ↓

References Dr Guerra's synthesis of the relevant literature BioEssays, Volume: 39, Issue: 5, First published: 20 February 2017. Front Cardiovasc Med. 2020; 7: 2.

CytoEpigenetics XIV. The details of AMPK mediated control over DNA methyl transferase thus coordinating bioenergetics with cell fate via the epitranscriptome. DJGPhD. 25.5.22 26.05.2022 29:57 ↓

References Dr. Guerra's synthesis of the epitranscriptome lecture notes Sci Signal. 2017 Jan 31; 10(464): eaaf7478.

CytoEpigeneticsXIII. Epitranscriptomics of Fatty acid Utilization is a driver of Heart-Failure associated Cardiorenal disease. Dr daniel J. Guerra. Authentic Biochemistry.22.5.22 22.05.2022 29:49 ↓

References Sci Signal. 2017 Jan 31; 10(464): eaaf7478 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Nat Commun. 2020; 11: 4664. Int J Biol Sci. 2015; 11(11): 1272–1280

CytoEpigenetics XII. The central role of mitochondria in regulating cell fate and metabolic switching is necessary and universal in epigenetic modification of gene expression. DJGPhD.20.5.22 21.05.2022 30:00 ↓

References Dr Guerra's lecture notations and synthesis Cell. 2014 Dec 18; 159(7): 1615–1625 Nat Commun. 2020; 11: 102.

CytoEpigenetics XI. The interactive intermediary metabolic architectonic of methylation and acetylation in epigenetic mediation of gene expression between the mitochondria and nucleus. DJGPhD.17.5.22 18.05.2022 29:11 ↓

References Dr Guerra's lecture notes Nat Commun. 2020; 11: 102. Cold Spring Harb Perspect Biol. 2013 Sep; 5(9): a017947.

CytoEpigenetics X. The IDH isofrom roles of mutant, hypoxic and constitutive activities mediate DNA, RNA and Histone3 Lys methylation patterns thus redirecting gene expression.DJGPhD.15.5.22 16.05.2022 29:57 ↓

References Dr Guerra's letures/reasoning SCIENCE ADVANCES • 22 May 2019 • Vol 5, Issue 5 Cell MetabolismVolume 22, Issue 2, 4 August 2015, Pages 304-311 Cell Chem Biol. 2020 May 21; 27(5): 538–550.e7.

Cytoepigenetics IX. c-MYC controls transcription of two dehydrogenases that alter the ratio of 2-HG/alphaKG thus controling epigenetic signatures on DNA and RNA in a cancer mouse model.DJGPhD.11May22 12.05.2022 29:40 ↓

References Dr Guerra's  Lecture notes Cell Chem Biol. 2020 May 21; 27(5): 538–550.e7 Circulation. 2020 Dec 15;142(24):2356-2370

CytoEpigenetics VIII. The epigenetic processors, TET and BRD4, mediate control over fatty acid oxidation, pyruvate metabolism, the electron tranport chain and OXPHOS. DJGPhD.8May22. Authentic Biochem 09.05.2022 25:22 ↓

References Dr Guerra's notes Circulation. 2020 Dec 15;142(24):2356-2370 Cancer Science June 2014. 105(9)

Cytoepigenetics VIIB. Warburg glycolysis explained from an epigenetic perspective plus some details of DNA methylation/demethylation. DJGPhD. Authentic Biochemistry Podcast 06May2022 07.05.2022 29:59 ↓

References Dr. Guerra's notes Cancer Res. 2011 May 1; 71(9): 3400–3409 Front. Neurosci., 17 May 2017

Cytoepigenetics VIIa. Micro RNA control over the electron transport chain and oxidative phosphorylation via binding to nuclear and mitochondrial transcripts. DJGPhD03.may 2022. Authentic Biochemistry 04.05.2022 21:38 ↓

References Dr Guerra's pathbiochemistry lecture notes Cancer Res. 2011 May 1; 71(9): 3400–3409

CytoEpigenetics V!. The 'magmatic' alteration of nuclear and mitochondrial gene expression via microRNA processing and translocalization is under bioenergetic control. DJGPhD. 2 May 2022. 03.05.2022 29:54 ↓

References Radiol Oncol. 2021 Dec; 55(4): 379–392

Cytoepigenetics V. Small interfering and micro RNA mediate mitochondrial and nuclear transcripts thus rendering cell fate, bioenergetics, and immunogenicity. DJGPhD.29.4.22. Authentic Biochemsitry 29.04.2022 29:54 ↓

References Guerra lecture notes/ideas Genes (Basel). 2014 Dec; 5(4): 865–886. Molecular Therapy—Nucleic Acids (2015) 4, e252 Int. J. Mol. Sci. 2016, 17(5), 719

Cytoepigenetics IV. Using Raman and IR spectroscopy to analyze the physical chemistry of pyrimidine nucleotide methylation. Dr. Daniel J. Guerra. 26.4.22. Authentic Biochemistry Podcast Productions 26.04.2022 29:50 ↓

References J of Computational Chemistry 2011 Volume32, Issue10: Pages 2077-2083

Cytoepigenetics IIIB. The Geometrical constraints decribed by the valence shell electron pair repulsion in biochemical reactivity. DJGPhD.25.4.22 25.04.2022 27:29 ↓

Dr Guerra organic chemistry notes and concepts

Cytoepigenetics IIIA. Dissection of the PPAR-gamma epigenetic retailoring. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 25.4.2022 25.04.2022 15:38 ↓

Review mini lecture

Cytoepigenetics II. The First Principle of Biochemical Epigenetics and the dialectic of methylated promoter region PPAR-gamma and peroxisomal mitigation between rodent and human. DJGPhD.24.4.22 25.04.2022 29:59 ↓

References Dr Guerra's ideas and concepts Cells. 2021 Jun; 10(6): 1355. Cells. 2019 Mar; 8(3): 227.

CytoEpigenetics I. Introduction. Dr. Daniel J. Guerra . 22.4.22. Authentic Biochemistry Podcast Productions 23.04.2022 29:50 ↓

References Introductory remarks from Guerra's research Trends in Cell Biology, 2017-06-01, Volume 27, Issue 6, Pages 453-463.

Authentic Biochemistry is moving to a remote geographical region but will do so seamlessly and with full dedication. Please SUBSCRIBE and take notice of the discussion I have recorded here. DJGPhD 20.04.2022 29:31 ↓

Dr Guerra takes this episode to redouble the committment of Authentic Biochemistry to providea detailed analysis and synthesis of current biomedical research science based on peer-reviewed published literature. Please become a regular subscriber! Grazie!

Diabetes XXXVI. Coda. Final lecture in diabetic dyslipidaemia. 20.04.2022 29:56 ↓

References Dr. Guerra lipid lectures Journal of Diabetes Research, 2016, Article ID 2372741, 12 pages Lipids in Health and Disease 2013.12(1):98 Cell Reports 2022. 38, 110566

Diabetes XXXV. Rodent model adipose mitochondrial respiratory contribution to obesity control involves a selenium protein and UCP1 sulfenylation. Dr Daniel J. Guerra. Authentic Biochemistry.18.4.22 19.04.2022 29:57 ↓

References Dr. Guerra Lipid and Intermediary Metabolism lectures Cell Reports 2022. 38, 110566 PNAS July 24, 2017 | 114 (32) 8649-8654