Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Dr Daniel J. Guerra

Episodes

Fatty Acids IV. Adipocyte lipases and the Diacylglycerol PKC/PKD circuit of cellular degeneration leading to chronic inflammation-associated obesity. DJGPhD.07.Feb.22. Authentic Biochemistry 08.02.2022 29:59

References Adv Exp Med Biol . 2017;960:135-160. Lipids in Health and Disease volume 19 , Article number: 113 (2020) Circulation Research. 2020.Volume: 128, Issue: 2, Pages: 232-245

Fatty Acids III. The inflammatory diseases and the correlation to dyslipidaemia. Dr Dan Guerra. 05 February 2022. Authentic Biochemistry Studios. 06.02.2022 29:56

References Dr. Guerra's lecture notes Infect Immun . 2013 Dec; 81(12): 4478–4489 Am J Gastroenterol. 2004 Nov;99(11):2147-9 Front Immunol. 2019 Jun 7;10:1309 Nat Rev Gastroenterol Hepatol. 2019 Dec 9.

Fatty Acids II. Obesity and lipotoxicity. Dr Daniel J. Guerra. Authentic Biochemistry 04. February 2022 05.02.2022 29:57

References Dr. Guerra's lecture notes Int J Mol Sci. 2021 Jan; 22(1): 330

Fatty Acids I. Dr. Daniel J. Guerra. 03.02.22. Authentic Biochemistry Podcast 04.02.2022 29:57

References Dr. Guerra's lecture notes Int J Mol Sci. 2021 Jan; 22(1): 330.

Anabolism VII. The allosteric control of purine biosynthesis involves complementarity and recipricol maintenance of steady state ADP/GDP ratios. DJGPhD. 31.01.22. Authentic Biochemistry. 01.02.2022 29:59

References Dr. Guerra's lecture notes

Anabolism VI. de novo Purine Nucleotide Biosynthesis. Dr. Dan Guerra. 30.01.22. Authentic Biochemistry 30.01.2022 29:56

References Dr. Guerra's lecture notes  Mol Genet Metab Rep. 2021 Mar; 26: 100709.

Anabolism V. The nucleic acids. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast.28.01.22 29.01.2022 29:54

References Dr. Guerra's lecture notes

Anabolism IV. Cholesterologenesis. Dr Daniel J. Guerra. 26 January 2022. Authentic Biochemistry Podcast 27.01.2022 30:00

From Dr. Guerra's lecture notes

Anabolism III. Fatty acid synthesis de novo . Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Productions. 25.01.22 26.01.2022 29:41

References Dr. Guerra lecture notes

Anabolism II. The role of Acetyl CoA Carboxylase isoform expression and discrete allosteric regulation in controlling hepatic fatty acid metabolism. Dr Dan Guerra. 23.01.22. Authentic Biochemistry. 24.01.2022 29:59

Malonyl CoA controls the categorical/biochemical logic of hepatic glucose and lipid homeostasis via metabolic inhibition of metabolic antimony. References Dr Dan Guerra Biochemistry Lecture Notes. 2010-2021  Vance and Vance Biochemistry of Lipids, Lipoproteins and Membranes  4th ed. 2002. Elsevier Publisher.

Anabolism I. Dr Daniel J. Guerra Authentic Biochemistry Podcast Production 22.01.22 23.01.2022 30:00

Basic reductive biosynthesis as an exemplar for this first lecture in anabolism.

Membrane lipid provide the architectonic signatures for cellular interactions including avirulence and either systemic and systematic-inflammatory disease. DJGPhD. 17.1.22. AuthenticBiochemistry 17.01.2022 59:49

References J Biol Chem. 2016 Feb.  291(7): 3658–3667 J Biol Chem 2013 Dec. 288 (52): 37355-37364  Biophys J. 2005 Feb;88(2):1091-103 Infect Immun. 2018 Jul; 86(7): e00035-18

Porphyria gingivalis derived dihydroceramides and serine dipeptide lipids secretion induce periodontitis and systemic hyperinflammation as associated with obesity and high sucrose diet. DJGPhD.16.1.22 17.01.2022 29:21

References Infect Immun. 2018 Jul; 86(7): e00035-18 J Biol Chem. 2019 Jun 7;294(23):9213-9224 Egyptian Journal of Basic and Applied Sciences. 2018. (5) 4 : 237-244 Arteriosclerosis, Thrombosis, and Vascular Biology. 2019. (39) 3: 432-445

Dihydroceramides as virulence factors in periodontal disease. Dr. Daniel J. Guerra Authentic Biochemistry. 15 January 2022 16.01.2022 29:21

References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Infect Immun. 2018 Jul; 86(7): e00035-18

Pathogenesis and Virulence are Linked to Alterations in the Infection Court via Secretion of Bacteriocins in Dental Plaque-producing Caries and S. pneumoniae Migration to the Lower Respiratory Tract. 14.01.2022 30:00

References J Dent Res. 2019 Nov;98(12):1315-1323 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1996.Vol. 335, No. 1, November 1, pp. 102–108,. Nature Reviews Microbiology. 2003. volume 1, pages219–230  Front. Microbiol. 2021. 14 July 

Acquired Molecular Evolution of Antibacterial Resistance Unintentionally Selected via Pharmacotherapy to Counteract Natural Avirulence. DJGPhD. Authentic Biochemistry. 12.Jan2022 13.01.2022 29:09

References Infect Immun . 2013 Dec; 81(12): 4478–4489 Journal of Molecular Evolution 2020. 88:26–40  PLoS One. 2016; 11(11): e0166656

Avirulence protein factor heterogeneity in multiple mammalian host/pathogen interactions. Dr. Dan Guerra. Authentic Biochemistry Production.11.Jan.2022 12.01.2022 29:50

References International Journal of Pharmacy and Pharmaceutical Sciences 2015 7(9):20-29 PLoS One. 2016; 11(11): e0166656. PLoS Pathog. 2019 Nov15;15(11):e1007687 Clin Microbiol Rev. 2006 Oct;19(4):728-62 Expert Rev Vaccines. 2009 Apr;8(4):447-54 Front. Microbiol., 14 July 2021

Avirulence in the Streptococci and the Two-Component System of Histidine Kinase and Response Regulator. II. DJGPhD. Authentic Biochemistry 09Jan2022 10.01.2022 29:57

References Front. Microbiol., 14 July 2021 PLoS One. 2016; 11(11): e0166656. The Lancet Microbe 2021; 2(7 ) Pages e291-e299

Avirulence and the mechanisms of pathobiochemistry I. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production. 08.Jan 2022 09.01.2022 29:57

Reference Front. Microbiol., 14 July 2021

The neuronal porosomal and synaptosomal structural anatomy as a product of membrane lipid vesicular trafficking, Dr. Daniel J. Guerra Authentic Biochemistry. 05 January 2022 06.01.2022 30:00

PLoS One. 2015 Jan 21;10(1):e0116919. Neurochem Res. 2015 Jan;40(1):59-69 Physiology. 2009. Volume 24 Issue 6 : 367-376

The bioenergetic glucose sensing network of the appetitive reward pathway is linked to the periphery via the neuroendocrine system. DJGPhD. Authentic Biochemistry. 04.Jan.2022 05.01.2022 29:19

The human neuroendocrine system is directly regulated and in communication with the  autonomic nervous system via cortical and diencephalonomic CNS nuclei. These converging networks coordinate satiety, glycemia, bioenergetics, oxygen transport, dietary input, digestion and muscular activity in direct association with pancreatic insulin/glucagon ratio dynamics.  References Molecular Neuro...

The Motor Neuron Association to Reward Pathway: Motor Neuron Disease , an Introduction. Dr. Daniel J. Guerra. 03 January 2022. Authentic Biochemistry Productions. 04.01.2022 29:56

Introduction to motor neuron structure/function relationships and the MND's including Amyotrophic Lateral Sclerosis. 

The CNS and Pandemic Obesity: The Appetitive Reward Pathway, Energy Expenditure, and Neuroendocrine Signaling. DJGPhD. 02.Jan.2022 Authentic Biochemistry Productions. 02.01.2022 30:00

The CNS processes nutritional (biochemical) signaling from the external and internal environment during and subsequent to dietary ingestion. During the  initiation phase, affective  (limbic) and executive (PFC/OFC) attention is  facilitative toward  ingestive behavior linked to appetitive hunger stimulation via neural, visceral, and endocrine networking including memory cues th...

A short Pharmacology lecture on New Year's Day 2022. Dr Daniel J. Guerra. Authentic Biochemistry 01.01.2022 29:54

Pharmacokinetics are discussed.

Appetitive Reward Pathway III.-Neurobiochemistry and Epigenetics of Addiction. DJGPhD. 31.12.21 Authentic Biochemistry 31.12.2021 29:49

Dopaminenergic pathways are corrupted by addictive behaviors especially the use/abuse of psychoactive drugs that may become behavioral reward saliencies linked to epigenomic modifications.