Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1334 episodes

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Author

Dr Daniel J. Guerra

Episodes

Avirulence protein factor heterogeneity in multiple mammalian host/pathogen interactions. Dr. Dan Guerra. Authentic Biochemistry Production.11.Jan.2022 12.01.2022 29:50

References International Journal of Pharmacy and Pharmaceutical Sciences 2015 7(9):20-29 PLoS One. 2016; 11(11): e0166656. PLoS Pathog. 2019 Nov15;15(11):e1007687 Clin Microbiol Rev. 2006 Oct;19(4):728-62 Expert Rev Vaccines. 2009 Apr;8(4):447-54 Front. Microbiol., 14 July 2021

Avirulence in the Streptococci and the Two-Component System of Histidine Kinase and Response Regulator. II. DJGPhD. Authentic Biochemistry 09Jan2022 10.01.2022 29:57

References Front. Microbiol., 14 July 2021 PLoS One. 2016; 11(11): e0166656. The Lancet Microbe 2021; 2(7 ) Pages e291-e299

Avirulence and the mechanisms of pathobiochemistry I. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production. 08.Jan 2022 09.01.2022 29:57

Reference Front. Microbiol., 14 July 2021

The neuronal porosomal and synaptosomal structural anatomy as a product of membrane lipid vesicular trafficking, Dr. Daniel J. Guerra Authentic Biochemistry. 05 January 2022 06.01.2022 30:00

PLoS One. 2015 Jan 21;10(1):e0116919. Neurochem Res. 2015 Jan;40(1):59-69 Physiology. 2009. Volume 24 Issue 6 : 367-376

The bioenergetic glucose sensing network of the appetitive reward pathway is linked to the periphery via the neuroendocrine system. DJGPhD. Authentic Biochemistry. 04.Jan.2022 05.01.2022 29:19

The human neuroendocrine system is directly regulated and in communication with the  autonomic nervous system via cortical and diencephalonomic CNS nuclei. These converging networks coordinate satiety, glycemia, bioenergetics, oxygen transport, dietary input, digestion and muscular activity in direct association with pancreatic insulin/glucagon ratio dynamics.  References Molecular Neuro...

The Motor Neuron Association to Reward Pathway: Motor Neuron Disease , an Introduction. Dr. Daniel J. Guerra. 03 January 2022. Authentic Biochemistry Productions. 04.01.2022 29:56

Introduction to motor neuron structure/function relationships and the MND's including Amyotrophic Lateral Sclerosis. 

The CNS and Pandemic Obesity: The Appetitive Reward Pathway, Energy Expenditure, and Neuroendocrine Signaling. DJGPhD. 02.Jan.2022 Authentic Biochemistry Productions. 02.01.2022 30:00

The CNS processes nutritional (biochemical) signaling from the external and internal environment during and subsequent to dietary ingestion. During the  initiation phase, affective  (limbic) and executive (PFC/OFC) attention is  facilitative toward  ingestive behavior linked to appetitive hunger stimulation via neural, visceral, and endocrine networking including memory cues th...

A short Pharmacology lecture on New Year's Day 2022. Dr Daniel J. Guerra. Authentic Biochemistry 01.01.2022 29:54

Pharmacokinetics are discussed.

Appetitive Reward Pathway III.-Neurobiochemistry and Epigenetics of Addiction. DJGPhD. 31.12.21 Authentic Biochemistry 31.12.2021 29:49

Dopaminenergic pathways are corrupted by addictive behaviors especially the use/abuse of psychoactive drugs that may become behavioral reward saliencies linked to epigenomic modifications.

Anhedonic and MDD- Associated Appetitive Reward Pathway Biochemistry and Pathophysiology II. DJGPhD. Authentic Biochemistry.30..12.21. 31.12.2021 29:50

References Front Neurosci. 2019; 13: 707 Nature Metabolism 2019.  1:754–764  Int. J. Mol. Sci. 2019, 20(6), 1505 Neuropsychiatr Dis Treat. 2015; 11: 875–888 Mol Psychiatry. 2016 Oct; 21(10): 1358–1365.

Appetitive Reward Pathway Biochemistry and Neural Circuitry Regulation I. Dr. Daniel J. Guerra. 29.12.21. An Authentic Biochemistry Production. 29.12.2021 30:00

References Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Front. Neurosci., 26 November 2019

AMPK and Immuno-Epigenetic Biochemistry Part 2/2/ DJGPhD. Authentic Biochemistry 27.12.21 28.12.2021 29:49

J Neuroinflammation. 2019; 16: 34 Nature Cell Biology, 02 Sep 2011, 13(9):1016-1023 Critical Reviews in Clinical Laboratory Sciences Volume 56, 2019 - Issue 7 Pages 472-492

AMPK and Immuno-Epigenetic Biochemistry Part 1. Dr. Daniel J. Guerra. 27.12.21. Authentic Biochemistry 27.12.2021 29:59

References Nat Cell Biol. 2019 Mar; 21(3): 397–407 CELL Volume 126, Issue 3, 11 August 2006, Pages 503-514 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Int J Biol Sci. 2015; 11(11): 1272–1280 Sci Signal. 2017 Jan 31; 10(464): eaaf7478. Front Immunol. 2019; 10: 345. J Neuroinflammation. 2019; 16: 34.

AMPK negatively regulates lipogenesis by phosphorylating ACCase 1&2 plus HMGCoA reductase thus supporting beta oxidation of fatty acids . Dr. Daniel J. Guerra. 22.12.21. Authentic Biochemistry 23.12.2021 29:54

Cell Metabolism 2020 31472-492 Amino Acids. 2012 Oct;43(4):1803-7 Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690

AMPK is associated with the POMC vs, NPY neuronal axis under Leptin Control. DJGPhD. 20.12.21 Authentic Biochemistry 21.12.2021 29:59

References HORMONES 2013, 12(2):172-191 Proc Natl Acad Sci U S A . 2002 Dec 24;99(26):17155-60 Eur J Endocrinol. 2017 176(5): R235–R246.

AMPK Allosteric Regulation and Interaction with the Opposing mTORC Network. Part 2. Dr. Daniel J. Guerra. Authentic Biochemistry 19.12.21 20.12.2021 30:00

Eur J Endocrinol. 2017 176(5): R235–R246 Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690

Bio-Molecular Regulator Series . AMPK. Part One. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production.19.12.21. 19.12.2021 30:00

An introductory lecture on the biomolecular sensor kinase, Adenosyl Mono-Phosphate (protein) Kinase;  AMPK. References Mol Genet Metab. 2013 Jul;109(3):260-8 PLoS One. 2016 Aug 16;11(8):e0161252. Experimental & Molecular Medicine volume 48, 224 (2016) Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690

T-lymphocyte and macrophage membrane CD38 ecto-enzyme mediated NAD catabolism is associated with ageing and the decline in Sirtuin-mediated deacylase activity. DJGPhD.11.Dec.21' Authentic Biochemistry 12.12.2021 29:57

References Cell Metabolism. 2016. 23, 1127–1139 Cells 2020, 9(1), 228 Front. Immunol., 31 May 2019 Int J Mol Sci. 2020 Nov; 21(22): 8609 Circ Res. 2018 Sep 14; 123(7): 868–885. Int J Mol Sci. 2019 Mar; 20(5): 1223

Aposteriori synthesis of neuroendocrine linked clock chronicity and the Senescent associated Secretory Phenotype through the synthetic apriori lens of NAD+. DJGPhD.10Dec21. Authentic Biochemistry 10.12.2021 29:47

References Nat Cell Biol. 2019 Mar; 21(3): 397–407 J Diabetes Metab Disord. 2020 Jul 21;19(2):1797-1825 Int. J. Mol. Sci. 2014, 15, 16848-16884

How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21 08.12.2021 30:03

Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation  can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppressor genes like p16INK4a while DNA Damage Repair (DDR) from pro-inflammatory cytokine production from senescent cells and Th1 lymphocytes can  inhibit commitment to mitosis and cytokinesis by ge...

Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21 07.12.2021 29:56

Cell fate from Either ageing associated senescence to programmed cell death OR cell proliferation is finely tuned to the splice variant  expression of Cell Cycle dependent kinase inhibitors and the relative production of pro-inflammatory cytokines under the synchrony of DNA Damage Repair (DDR), telomerase expression decline, and the protective role of the Senescence Associated Secretory Pheno...

Ageing and Asymmetric Dimethylarginine (ADMA)in Endothelial Nitric Oxide Synthase inhibition-associated decrease in respiratory vasodilation. Dr Dan Guerra 24.11.21 Authentic Biochemistry 25.11.2021 29:37

Age Ageing , Volume 48, Issue 6, November 2019, Pages 776–782 Biomedicines. 2020 Aug 6;8(8):277

Closing the window and drawing the curtain: cancer phenotypes are resolute signatures of Immunosenescence and inflammaging induced epigenetic collapse of vital biochemical homeostasis. DJGPhD.20/11/21 21.11.2021 29:29

Dr. Guerra authentically arrives at the inveighing cancer paradigm contribution to the sickness unto death.

Sealing Fate: Immunosenescent and inflammatory mechanisms combine the ineffectual with the increscent pathophysiology of sickness unto death. DJGPhD. 17.11.21 18.11.2021 29:16

Nutrients. 2020 Mar; 12(3): 622. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43.The Immune System and Its Dysregulation with Aging Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Springer Publishers

The interplay between Immunosenescence and inflammaging conduct the innate and acquired immune response toward functional cellular rigidity and incompetence obtaining morbidity and mortality. DJGPhD. 14.11.2021 29:52

1.Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43. The Immune System and Its Dysregulation with Aging.  Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Springer Publishers. 2. Aging (Albany NY). 2019 Apr 30; 11(8): 2343–2351. 3. Immun Ageing. 2020; 17: 2