Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Author

Dr Daniel J. Guerra

Episodes

Membrane Biochemistry XX. Loss of CNS CA1-Caveolae Formation in Obese Type-2 Diabetics is Linked to insulin Resistance and Alzheimer's Disease. DJGPhD24.7.22. Authentic Biochemistry. 24.07.2022 26:15

References Archivum Immunologiae et Therapiae Experimentalis 2013 Apr;61(2):119-25. Journal of Neuroscience 23 October 2019, 39 (43) 8576-8583 Annual Review of Cell and Developmental Biology 2018 Volume 34, pp 111-136

Membrane Biochemistry XIX. Oxysterols and LDLR in atherosclerosis: transcriptional mediation of membrane control over cholesterol homeostasis. 21.7.22. DJGPhD.Authentic Biochemistry 21.07.2022 29:52

References Dr Guerra's lipids lectures Nature  2008. volume 455, pages40–41. Nature Immunology 2013. volume 14, pages893–900 European Heart Journal 2021. Vol 12 Dec.

Membrane Biochemistry XVIII> Valproic acid and Platelt Activating Factor:Membrane lipids in Alzheimer's DiseaseDJGPhD 18.7.22 Authentic Biochemistry 19.07.2022 29:58

References Dr Guerra's lipid lecture notes European Medicines Agency•20/05/2022 Pharmaceuticals (Basel). 2022 Feb; 15(2): 192 Neuropharmacology Volume 128 , January 2018, Pages 54-62

Membrane Biochemistry XVII. Epoigenetic changes in protein controlled membrane lipid transport in human disease. DJGPhD.14.7.22 15.07.2022 29:52

References Dr Guerra's notes Biomedicines. 2021 Dec; 9(12): 1908 RNA. 2020 Aug; 26(8): 903–909 Journal of Alzheimer's Disease,  1 Jan. 2019 : 743 – 750.

Membrane Biochemistry XVI. The Acid Sphingomyelinase Deficiencies. Dr Dan Guerra. 13.7.22 Authentic Biochemistry 13.07.2022 29:59

References Dr. Guerra's notes Biochem Biophys Res Commun. 2007 Aug 31;360(3):593-9 Cell Death Dis. 2021 Feb; 12(2): 180.

Membrane Biochemistry XV. REST mediated gene repression and membrane function and plaque formation in atherosclerosis. DJGPhD. 11JUly22. Authentic Biochemistry 12.07.2022 59:51

References Pharmacology & Therapeutics Available online 27 June 2022,  paper # 108237 Cell Death Dis. 2021 Feb; 12(2): 180. Dr Guerra's notes

Membrane Biochemistry XIV. Apoptosis and Necroptosis review. Dr. Daniel J. Guerra. 8 July 2022. Authentic Biochemistry Podcast 09.07.2022 26:24

References Dr Guerra's notes Oncogene. 2009 Sep 3;28(35):3097-110 Mol Cell Biol. 2005 Aug;25(15):6363-79 J Neuroinflammation. 2019; 16: 236.

Membrane Biochemistry XIII.Fatty acid induced membrane protein phosphorylation can shift pro-oncogenic to apoptotic cell fate in human breast cancer cell lines. DJGPhD. 5July 2022 Authentic Biochem. 05.07.2022 29:46

References Dr. Guerra's notes The Journal of Nutrition, Volume 137, Issue 3, March 2007, Pages 548–553

Membrane Biochemistry XII. The specificity of membrane lipid raft molecular species and the dialectics of protein sorting. DJGPhD.3 July 2022 Authentic Biochemistry. 04.07.2022 29:48

References Dr. Guerra's notes The Journal of Nutrition, Volume 137, Issue 3, March 2007, Pages 548–553 Front Immunol. 2019; 10: 1309. Int J Mol Sci. 2019 Oct 11;20(20):5028

Membrane Biochemistry XI. Inflammasomes and omega three fatty acid involvement in various pathogenic and human disease states. DJGPhD.02.July 2022. 02.07.2022 30:00

References Front Immunol. 2019; 10: 1309. Int J Mol Sci. 2019 Oct 11;20(20):5028.

Membrane Biochemistry X. Dialectical Event Ontologies and the Complexity of Biological Systems. Dr. Daniel; J.Guerra 2 July 2022 Authentic Biochemistry 02.07.2022 29:41

References Dr Guerra's ideas 

Membrane Biochemistry IX. Omega Three fatty acid utilization via oxygenation to control inflammation. DJGPhD. 30.6.22 Authentic Biochemistry Podcast production 01.07.2022 29:50

References Dr Guerra's notes Int J Mol Sci. 2019 Oct 11;20(20):5028

Membrane Biochemistry VIII. The basics of lipid membranes. Part 1. Dr Daniel J. Guerra. Authentic Biochemistry Podacst Production. 28.6.22 29.06.2022 29:58

References Dr Guerra's lectures PNAS September 28, 2010 107 (39) 16783-16787;

Membrane Biochemistry VII. DNA methylation and histone acetylation may be at the core of memory and learning via LTP associated Integral Membrane Excitation. DJGPhD.24.6.22 Authentic Biochemistry. 25.06.2022 29:48

References Sci Signal. 2016 Aug 23; 9(442): ra83. Dr Guerra's Neuroscience lectures

Membrane Biochemistry VI. The involvement of membrane lipid omega 3 fatty acids in LTP and memory acquisition. Part 1. Dr Guerra. 23.6.22. Authentic Biochemistry 24.06.2022 30:00

References Dr Guerra lecture notes Nature Communications volume 11, Article number: 6133 (2020) Current Biology Volume 31, Issue 11, 7 June 2021, Pages 2274-2285.e5 Eur J Neurosci. 2019 Jan;49(1):40-50

Membrane Biochemistry V. Epigenetic alteration of gene expression is predicated by free will induced synaptic plasticity as an event ontology. DJGPhD. 21.6.22 Authentic Biochemistry 21.06.2022 29:35

References Dr Guerra's notes,concepts and ideas Sci Signal. 2016 Aug 23; 9(442): ra83.

Membrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic Biochemistry 21.06.2022 29:50

References Dr Guerra's notes Sci Signal. 2016 Aug 23; 9(442): ra83 Front. Pharmacol., 24 April 2019

CytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022 06.06.2022 29:54

References Dr Guerra's notes Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:436 JAMA. 2008;299(11):1345-1350

CytoEpigenetics XVIII. Membrane lipid architectonics organized for cell cycle and both nuclear and mitochondrial biochemical mediation of gene expression. Dr. Dan Guerra. 05 June 2022 05.06.2022 20:02

References Dr Guerra's synthesis of lecture material Histochemistry and Cell Biology volume 145, pages275–286 (2016) Biol Rev Camb PhilosSoc.. 2018 May;93(2):827-844.

CytoEpigenetics XVII. The role of ceramide metabolism in epigenetic and bioenergetic cross talk among multiple subcellular compartments. Dr Dan Guerra. 03June2022 Authentic Biochemistry Podcast 04.06.2022 29:40

References Dr Guerra's synthesis of lectures Scientific Reports volume 5, Article number: 15292 (2015)

CytoEpigenetics XVI. The Mt DNA replicase and helicase enzymes are epigenetically nuclear encoded and localize to the mitochondrial membrane into lipid rafts containing cholesterol. DJGPhD. 2June2022 02.06.2022 29:50

References Dr Guerra's lecture sytheses Scientific Reports volume 5, Article number: 15292 (2015)

CytoEpigenetics XV.An AMPK phosphorylation cascade promoting mTOR pro-translational induction of NFkappa-B SASP transcription is modulated by NAD+ Sirtuin and PARP during Chromatin retailoring.DJGPhD 28.05.2022 29:59

References Dr Guerra's synthesis of the relevant literature BioEssays, Volume: 39, Issue: 5, First published: 20 February 2017. Front Cardiovasc Med. 2020; 7: 2.

CytoEpigenetics XIV. The details of AMPK mediated control over DNA methyl transferase thus coordinating bioenergetics with cell fate via the epitranscriptome. DJGPhD. 25.5.22 26.05.2022 29:57

References Dr. Guerra's synthesis of the epitranscriptome lecture notes Sci Signal. 2017 Jan 31; 10(464): eaaf7478.

CytoEpigeneticsXIII. Epitranscriptomics of Fatty acid Utilization is a driver of Heart-Failure associated Cardiorenal disease. Dr daniel J. Guerra. Authentic Biochemistry.22.5.22 22.05.2022 29:49

References Sci Signal. 2017 Jan 31; 10(464): eaaf7478 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Nat Commun. 2020; 11: 4664. Int J Biol Sci. 2015; 11(11): 1272–1280

CytoEpigenetics XII. The central role of mitochondria in regulating cell fate and metabolic switching is necessary and universal in epigenetic modification of gene expression. DJGPhD.20.5.22 21.05.2022 30:00

References Dr Guerra's lecture notations and synthesis Cell. 2014 Dec 18; 159(7): 1615–1625 Nat Commun. 2020; 11: 102.