Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1333 episodes

Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.

Be sure to visit the podcast's website and support the creator: podcasters.spotify.com

Author

Dr Daniel J. Guerra

Episodes

Holiday Ethanol Abuse Lecture I. EtoH ingestion, while intoxicating redox metabolism is also a membrane lipid -protein interacting agent that corrupts inwardly rectifying K voltage gated channels. 30.12.2022 30:00

References Dr Guerra EtOH lectures PNAS November 5, 2013 vol. 110 no. 45 Alcohol, 2017-12-01, Volume 65, Pages 51-62

ImmunoEpigeneticsIX. Promoter/Enhancer proximal and distal epigenetic signatures and transcription factor protein heterogeneity compose gene expression event ontology.DJGPhD.29.12.22.AuthenticBiochem 29.12.2022 29:54

References Proc Natl Acad Sci U S A. 2021 Nov 16; 118(46) Nat Rev Mol Cell Biol. 2021 Dec 1; 22(12): 815–833. 

More "mere" epistemology opening a door to metaphysics II. Non-canonical epi-rational and epi-empirical retailoring of understanding and imagination via research scientific endojectification.DJGPhD. 25.12.2022 24:42

References Dr. Guerra's ongoing flight into the telos of research science.

ImmunoepigeneticsVIII. Protective immunotolerant neonate Th1 inactivity involves IL-12 p35subunit promoter methylation. DJGPhD.23.12.22. Authentic Biochemistry Podcast 24.12.2022 29:54

References Trends in Immunology. REVIEW. 2017. VOLUME 38, ISSUE 4, P287-297. J Biomed Sci. 2014 Aug 19;21(1):76.

Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB. 23.12.2022 30:00

References Neural Plasticity. 2019; 2019: 1648736. Molecular Pharmacology May 2017, 91 (5) 451-463.

Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem. 21.12.2022 29:58

References PLoS One. 2011;6(5):e17711 J Neuroinflammation. 2020; 17: 207 Front Neurosci. 2019 Nov 26;13:1280

Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast 21.12.2022 21:15

References Dr Guerra's ideas and concepts concerning the epistemics of research science . Lecture I.

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast 18.12.2022 30:00

References Dr Guerra EtOH lectures Dr Guerra Reward Pathway lectures Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Biochemistry and Cell Biology. 2019. Volume 97, Number 4.August.

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health. 18.12.2022 30:00

References Dr Guerra EtOH lectures Physiol Rev 2016. 96: 1261–1296. Clinical and Molecular Teratology. 2016. Volume 106, Issue 9 Pages 749–760

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem. 17.12.2022 29:55

References Dr Guerra's EtOH lectures Cells. 2020 Sep; 9(9): 2125.

Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise. 16.12.2022 30:00

References Dr. Guerra's EtOH lectures Clinical and Molecular Teratology 2016. Volume 106:749–760 Stat Pearls. Embryology and Gastrulation. NIH 2022. https://www.ncbi.nlm.nih.gov/books/NBK554394/

Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD. 14.12.2022 29:51

References Clinical and Molecular Teratology Volume 106, Issue 9 September 2016 Pages 749–760 Alcohol, 2017-12-01, Volume 65, Pages 51-62

Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry 11.12.2022 30:00

References Arthritis Res Ther. 2021; 23: 19. Frontiers in Immunology.  November 2014. 21(578):1

ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22 09.12.2022 29:53

References Frontiers in Immunology November 2014. 21(578):1 Clin Epigenetics. 2017; 9: 94  Cancer Cell International September 2020. 20(1):429

ImmunoepigeneticsV. TCR activation and the integration of cell senescence with epigenetic authorship and reading-mediated tumorigenesis. DJGPhD.07Dec22. Authentic Biochemistry 07.12.2022 29:52

References Cancer Cell Int. 2022; 22: 272. Cell Mol Life Sci. 2013 Oct;70(20):3753-72 PLoS Biol. 2013 Mar; 11(3): e1001502

ImmunoEpigeneticsIV. Membrane lipid raft components dynamically mediate Tcell reception, hippocampal pyrimidal neuron endocytosis, and lung cancer cell mesenchymal to endothelial transition.DJGPhD. 05.12.2022 29:28

References Respir Res. 2017 Sep 6;18(1):168 Front Behav Neurosci. 2020; 14: 24 JLR Methods| 2020.Volume 61, ISSUE 11, P1512-1523, November 01

Immunoepigenetics 3. EtOH abuse interrupts membrane lipid raft -mediated TCR signaling by decreasing the TF NFAT nuclear translocation and IL-2 transcription.DJGPhD.04.DEC.22.Authentic Biochemistry. 04.12.2022 29:08

Reference Alcohol Clin Exp Res. 2011 Aug; 35(8): 1435–1444

Immunoepigenetics 2. Treg and ILC differentiation and the evolution of lymphocytic response specificity incl. B cell class switch recombination and somatic hypermutation deamination.DJGPhD.2.12.22 02.12.2022 30:00

References Advances in Immunology. 2011 v.109.Pp125 Biomed J. 2014 Sep-Oct;37(5):269-83 Alcohol Clin Exp Res. 2011 Aug; 35(8): 1435–1444 Cell Reports 10, 2043–2054, March 31, 2015 Front. Immunol., 28 September 2015 | https://doi.org/10.3389/fimmu.2015.00493 Front. Immunol., 07 January 2021 Sec. T Cell Biology https://doi.org/10.3389/fimmu.2020.609891

Membrane Biochemistry 86/Immunoepigentics1. The complex divergent roles of Inhibitor of DNA (Id) binding proteins in terminal differentiation and disease states. DJGPhD.01.12.22.Authentic Biochemistry 02.12.2022 30:01

References Cell Reports Volume 17, Issue 11, 13 December 2016, Pages 2827-2836 Cardiovascular Research, cvac159, https://doi.org/10.1093/cvr/cvac159.Published:27 September 2022 Cancer Med. 2012 Oct; 1(2): 176–186. Nat Immunol. 2011 Nov 6; 12(12): 10 Nat Immunol. 2014 Aug; 15(8): 767–776 Stem Cells. 2007 Feb;25(2):500-10.

Membrane Biochemistry 85. EBV latent membrane protein induction of haemopoietic proliferative disease and Id repressor protein transcriptionally mediated terminal differentiation.DJGPhD.30.11.22. 30.11.2022 29:58

References Stem Cell Reviews and Reports volume 17, pages 1486–1499 (2021) BMC Cancer. 2008 Dec 19;8:379 Curr Top Microbiol Immunol. 2015;391:119-49.

Membrane Biochemistry 84. Isolation of membrane protein using non-ionic detergents exposes the prescence of cellular lipid raft domains. DJGPhD. 29.11.22. Authentic Biochemistry. 30.11.2022 29:56

References Methods Mol Biol. 2021; 2268: 1–20

Membrane Biochemistry 83. Countercurrent distribution theory of membrane lipid raft mediated endomebranous sequence ontology. DJGPhD.26.11.22 26.11.2022 29:59

Referernces Dr. Guerra's deductive reasoning

Membarne Biochemistry 82. Coda in absentia. Redux of the epistemological lens and the membrane lipid raft resurfaces. Dr. Daniel J. Guerra. 23.11.22. Authentic Biochemistry Podcast 23.11.2022 29:52

References Timaeus, Plato Dr Guerra's thoughts and lectures N Engl J Med 2005;353:604-15

Membrane Biochemistry 81. Synopsis. Logical judgment and square of opposition applied to lipids as transcription factors and membrane sequence derivatives respectively. DJGPhD19.11.22.Authentic Bioch 19.11.2022 29:59

References Dr Guerra's unpublished writings

Membrane Biochemisty.Steroidogenic endo-nuclear sphingolipid metabolism involving ganglioiside turnover mediates transcription factor de-repression via DAG kinase.DJGPhD.18.11.22. 19.11.2022 30:00

References Dr Guerra's  lipid lectures Front Pharmacol. 2020; 11: 569802 B iomolecules 2022 , 12 (10), 1434; https://doi.org/10.3390/biom12101434