Authentic Biochemistry

CytoEpigenetics XI. The interactive intermediary metabolic architectonic of methylation and acetylation in epigenetic mediation of gene expression between the mitochondria and nucleus. DJGPhD.17.5.22 18.05.2022 29:11 ↓

References Dr Guerra's lecture notes Nat Commun. 2020; 11: 102. Cold Spring Harb Perspect Biol. 2013 Sep; 5(9): a017947.

CytoEpigenetics X. The IDH isofrom roles of mutant, hypoxic and constitutive activities mediate DNA, RNA and Histone3 Lys methylation patterns thus redirecting gene expression.DJGPhD.15.5.22 16.05.2022 29:57 ↓

References Dr Guerra's letures/reasoning SCIENCE ADVANCES • 22 May 2019 • Vol 5, Issue 5 Cell MetabolismVolume 22, Issue 2, 4 August 2015, Pages 304-311 Cell Chem Biol. 2020 May 21; 27(5): 538–550.e7.

Cytoepigenetics IX. c-MYC controls transcription of two dehydrogenases that alter the ratio of 2-HG/alphaKG thus controling epigenetic signatures on DNA and RNA in a cancer mouse model.DJGPhD.11May22 12.05.2022 29:40 ↓

References Dr Guerra's  Lecture notes Cell Chem Biol. 2020 May 21; 27(5): 538–550.e7 Circulation. 2020 Dec 15;142(24):2356-2370

CytoEpigenetics VIII. The epigenetic processors, TET and BRD4, mediate control over fatty acid oxidation, pyruvate metabolism, the electron tranport chain and OXPHOS. DJGPhD.8May22. Authentic Biochem 09.05.2022 25:22 ↓

References Dr Guerra's notes Circulation. 2020 Dec 15;142(24):2356-2370 Cancer Science June 2014. 105(9)

Cytoepigenetics VIIB. Warburg glycolysis explained from an epigenetic perspective plus some details of DNA methylation/demethylation. DJGPhD. Authentic Biochemistry Podcast 06May2022 07.05.2022 29:59 ↓

References Dr. Guerra's notes Cancer Res. 2011 May 1; 71(9): 3400–3409 Front. Neurosci., 17 May 2017

Cytoepigenetics VIIa. Micro RNA control over the electron transport chain and oxidative phosphorylation via binding to nuclear and mitochondrial transcripts. DJGPhD03.may 2022. Authentic Biochemistry 04.05.2022 21:38 ↓

References Dr Guerra's pathbiochemistry lecture notes Cancer Res. 2011 May 1; 71(9): 3400–3409

CytoEpigenetics V!. The 'magmatic' alteration of nuclear and mitochondrial gene expression via microRNA processing and translocalization is under bioenergetic control. DJGPhD. 2 May 2022. 03.05.2022 29:54 ↓

References Radiol Oncol. 2021 Dec; 55(4): 379–392

Cytoepigenetics V. Small interfering and micro RNA mediate mitochondrial and nuclear transcripts thus rendering cell fate, bioenergetics, and immunogenicity. DJGPhD.29.4.22. Authentic Biochemsitry 29.04.2022 29:54 ↓

References Guerra lecture notes/ideas Genes (Basel). 2014 Dec; 5(4): 865–886. Molecular Therapy—Nucleic Acids (2015) 4, e252 Int. J. Mol. Sci. 2016, 17(5), 719

Cytoepigenetics IV. Using Raman and IR spectroscopy to analyze the physical chemistry of pyrimidine nucleotide methylation. Dr. Daniel J. Guerra. 26.4.22. Authentic Biochemistry Podcast Productions 26.04.2022 29:50 ↓

References J of Computational Chemistry 2011 Volume32, Issue10: Pages 2077-2083

Cytoepigenetics IIIB. The Geometrical constraints decribed by the valence shell electron pair repulsion in biochemical reactivity. DJGPhD.25.4.22 25.04.2022 27:29 ↓

Dr Guerra organic chemistry notes and concepts

Cytoepigenetics IIIA. Dissection of the PPAR-gamma epigenetic retailoring. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 25.4.2022 25.04.2022 15:38 ↓

Review mini lecture

Cytoepigenetics II. The First Principle of Biochemical Epigenetics and the dialectic of methylated promoter region PPAR-gamma and peroxisomal mitigation between rodent and human. DJGPhD.24.4.22 25.04.2022 29:59 ↓

References Dr Guerra's ideas and concepts Cells. 2021 Jun; 10(6): 1355. Cells. 2019 Mar; 8(3): 227.

CytoEpigenetics I. Introduction. Dr. Daniel J. Guerra . 22.4.22. Authentic Biochemistry Podcast Productions 23.04.2022 29:50 ↓

References Introductory remarks from Guerra's research Trends in Cell Biology, 2017-06-01, Volume 27, Issue 6, Pages 453-463.

Authentic Biochemistry is moving to a remote geographical region but will do so seamlessly and with full dedication. Please SUBSCRIBE and take notice of the discussion I have recorded here. DJGPhD 20.04.2022 29:31 ↓

Dr Guerra takes this episode to redouble the committment of Authentic Biochemistry to providea detailed analysis and synthesis of current biomedical research science based on peer-reviewed published literature. Please become a regular subscriber! Grazie!

Diabetes XXXVI. Coda. Final lecture in diabetic dyslipidaemia. 20.04.2022 29:56 ↓

References Dr. Guerra lipid lectures Journal of Diabetes Research, 2016, Article ID 2372741, 12 pages Lipids in Health and Disease 2013.12(1):98 Cell Reports 2022. 38, 110566

Diabetes XXXV. Rodent model adipose mitochondrial respiratory contribution to obesity control involves a selenium protein and UCP1 sulfenylation. Dr Daniel J. Guerra. Authentic Biochemistry.18.4.22 19.04.2022 29:57 ↓

References Dr. Guerra Lipid and Intermediary Metabolism lectures Cell Reports 2022. 38, 110566 PNAS July 24, 2017 | 114 (32) 8649-8654

Diabetes XXXIV. White vs brown adipocytes and the role of transcription factors and metabolic enzyme expression to mediate bioenergetics vs.lipogenesis in store depot fat.DJGPhD.17.4.22. Authentic B. 18.04.2022 30:00 ↓

References Dr. Guerra's lipid lecture archives PNAS July 24, 2017 | 114 (32) 8649-8654 Int J Mol Sci. 2019 Oct; 20(19): 4924

Diabetes XXXIII. Synthesis of lecture arc Part 2. Dr Daniel J. Guerra. Authentic Biochemistry Podcast Studios. 16.4.22 16.04.2022 29:58 ↓

References Dr. Guerra's notes

Diabetes XXXII. Fatty acid oxygenation and use of eicosanoid molecular species to regulate T2D-linked inflammation via the agonization of the nuclear receptor transcription factor PPAR.DJGPhD 15.4.22 15.04.2022 29:59 ↓

References Dr Guerra lipid lecture notes Biophysical J. Volume 110, Issue 11, 7 June 2016, Pages 2397-2406 Am J Pathol. 2020 Sep; 190(9): 1782–1788

Diabetes XXXI. REDOX biochemistry mini-review and the roles of essential fatty acid elongation/desaturation metabolism and COX/LOX oxygenation as ligands for PPAR isoforms in T2D pharmacotherapy. 14.04.2022 29:55 ↓

References Dr. Guerra lecture material Nutr J. 2014; 13: 17.

Diabetes XXX. The pleitropic roles of free fatty acids and PPAR's as mediating insulin sensitivity, intermediary metabolism and the inflammatory response in T2D.Dr Daniel J. Guerra 13.4.22. Authentic 13.04.2022 29:45 ↓

References Dr. Guerra lecture notes Prog Neurobiol. 2018 Apr-May; 163-164: 27–58. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:28–40

DiabetesXXIX. THe CNS axis of Obesity-linked T2D via alterations in PPAR transcription factor mediated expression of ameliorative hippocampal AMPAR and LTP neural transmission in Alzheimer's Discsease 12.04.2022 29:37 ↓

References Dr. Guerra's Lecture Notes Journal of the American College of Nutrition. 2019. 38:8, 693-702. Curr Diabetes Rev. 2020;16(8):797-806

Diabetes XXVIII. Diabetic nephropathy is a consequence of non-esterified free fatty acid associated ceramide induction of the IRS-1 phosphorylation in glomerular podocytes inducing inflammation 08.04.2022 30:00 ↓

References Dr Guerra lecture notes Front. Endocrinol., 14 October 2014. Sci Rep. 2020; 10: 21628.

Diabetes XXVII. Dyslipidaemia and the Insulin Resistance Axis. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast 7April2022. 07.04.2022 29:28 ↓

References Dr. Guerra's lectures Curr Med Chem. 2017;24(17):1827-1852 Cancer Res. 2018 Apr 1; 78(7): 1713–1725

Diabetes XXVI. Adipogenic and hypertrophic adiposity differentially control dyslipidaemia and Insulin resistance in association with pro-inflammatory cytokine induced T2D and breast cancer.DJGPhD. 05.04.2022 29:55 ↓

References Dr. Guerra's lipid lecture notes Cancer Res. 2018 Apr 1; 78(7): 1713–1725. Progress in Lipid Research Volume 74, April 2019, Pages 145-159