Authentic Biochemistry

A Biochemical Partita 4th Movement.Regulation of gluconeogenesis vs. glycolysis and the fatty acyl CoA beta-oxidation pathway provide REDOX and allosteric control over bioenergetics. DJGPhD.01FEB23. 02.02.2023 29:03 ↓

References&Inspirations Guerra intermediary metabolic lectures https://youtu.be/nDidA8_gfbU

ImmunoepigeneticsXXIV. The Cathelicidin anitmicrobial peptide cysteine protease domain may contibute to innate immune defense against cancer via epigenetically regulated ferroptosis.DJGPhD.1Feb23 01.02.2023 30:00 ↓

References Peptides . 2020 Jan;123:170177 Molecular Cancer. 2020. volume 19, Article number: 39.

A Biochemical Partita 3rd movement. Principle of Sufficient Reason and the refutation of biological reductionism. DJGPhD.31.1.23. Authentic Biochemistry Podcast Productions 01.02.2023 28:47 ↓

Inspirations https://youtu.be/XkfsGCIiHb4

A Biochemical Partita. 2nd movement. DJGPhD. 29.1.23 Authentic Biochemistry Podcast Production 30.01.2023 29:56 ↓

References Guerra lecture notes https://youtu.be/X0T6KysSejQ

A Biochemical Partita. Ist movement. DJGPhD. 28.1.23 Authentic Biochemistry Podcast Production 28.01.2023 29:53 ↓

Inspiration https://music.youtube.com/watch?v=BR1_FhZdUIM&feature=share

ImmunoepigeneticsXXIII. Vitamin D hydroxylation mediated alteration of VDR chromatin retailoring and alteration of promoter methylation generate a dialectically ontological pathophysiology.DJGPhD. 28.01.2023 29:39 ↓

References Sci Transl Med . 2015 Apr 8;7(282):282ra47 Cell Physiol Biochem . 2018;47(3):1060-1073 Hum Genomics. 2021; 15: 24

Immunoepigenetics XXII. The role of circulating vitaminD in the regulation of innate immune antimicrobial peptide generation. DJGPhD. 25.1.23 Authentic Biochemistry 26.01.2023 30:00 ↓

References Hum Genomics. 2021; 15: 24 Nutrients. 2022 Jan; 14(2): 284

ImmunoepigeneticsXXI. Methylation patterns of CpG vs histone modification of specific loci must be sequenced to verify pathophysiological events. DJGPhD. 22.1.23 Authentic Biochemistry. 22.01.2023 29:59 ↓

References Hum Genomics. 2021; 15: 24 JCI Insight. 2020 Sep 3;5(17):e138443 N ature Reviews Genetics volume 14 , pages 204–220 (2013)

A Special Message for Authentic Biochemists. A direct way to contact your host and a little more. DJGPhD.21.1.23 Authentic Biochemistry Productions. 21.01.2023 10:36 ↓

Rather than referencing this episode I am enlisting your input. Please email me at our new email address: authenticbiochemistry@gmail.com   Sincerely, Dr Guerra

Immunoepigenetics XX. Inflammatory cytokines and associated transcription factors are controlled by epigenetically regulated microRNA. DJGPhD.20.1.23. Authentic Biochemistry. 21.01.2023 29:49 ↓

References Dr Guerra's micro RNA lectures FEBS J Volume278, Issue10 May 2011. Pages 1598-1609 International Journal of Molecular Sciences 2013. 14(11):22796-22816  Front. Genet., 07 September 2021

ImmunoEpigeneticsXIX. Diet-induced and db/db mouse model Type 2 diabetes is dissimilar to the human pathophysiology but shares epigenetic mechanisms controlling pro-inflammatory PLA2/COX2/PGE2. 20.01.2023 29:58 ↓

References Dr. Guerra's lipid lectures JCI Insight. 2020 Sep 3;5(17):e138443 Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7): 4061–4065.

ImmunoepigeneticsXVIII. Variable DNA and histone methylation in cooperation with micro RNA mediate macrophage plasticity,inflammation and wound repair in T2D patients. DJGPhD.18.1.23.AuthenticBiochem. 19.01.2023 30:00 ↓

Reference JCI Insight . 2020 Sep 3;5(17):e138443

Epistemological integration into realized metaphysicsV. Energy and mass like space and time are estimations of uncertain certainties yet are used as universals in physico-chemical event ontologies 16.01.2023 30:00 ↓

References Thomas Hobbs-Leviathan Heraclitus-Collected Works

Immunoepigenetics XVII.TGF beta involvement in disease pathology and normal developmental physiology demonstrates the complexity of categorical ontologies in biochemical events.DJGPhD.13.1.23.AB 14.01.2023 29:56 ↓

References JCI Insight . 2020 Sep 3;5(17):e138443 J Clin Invest. 2022 Apr 15;132(8):e151020

ImmunoepigeneticsXVI. TGFbeta 1 and subfamily member Activin A diferentially alter the categorical valence and modality of Th17 cells in multiple sclerosis via receptor kinase modulatory specificity. 13.01.2023 30:00 ↓

References Immunity. 2021 Feb 9; 54(2): 308–323.e6. J Endocrinol. 2003 Sep;178(3):479-89.

ImmunoepigeneticsXV. In utero fetal exposure to high concentration of maternal cortisol can induce histone code hypomethylation proximal to the TGF B-1 receptor resulting in adult OA.DJGPhD.12Jan23 13.01.2023 29:51 ↓

References Stem Cell Res Ther. 2021; 12: 163 Biomedicines. 2021 Nov; 9(11): 1666

ImmunoepigeneticsXIV. Epithelial cell metabolism and the potential transition to mesenchyma is regulated by TGF-Beta and linked to ALK-1 receptor associated OA. DJGPhD.11Jan23.Authentic Biochemistry. 11.01.2023 30:00 ↓

References Clin Podiatr Med Surg . 2001 Jan;18(1):35-53 Biomedicines. 2021 Nov; 9(11): 1666

Biochemical Consequences of Sensorial Phenomenology V. The possibility of Necessary biological modality . DJGPhD. 09Jan23. Authentic Biochemistry. 10.01.2023 29:57 ↓

References A plenum of  time.

ImmunoepigeneticsXIII. The interplay of NFKappB and articular cartilage glycosaminoglycan metabolism in regulating pro-inflammatory cytokine expression in OA. DJGPhD.Authentic Biochemistry. 08Jan2023 08.01.2023 29:17 ↓

references J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161 Connect Tissue Res. 2017 Jan; 58(1): 49–63.

ImmunoepigeneticsXII. Osteo-Arthritis 1. Clinical manifestation and the role of TGF-Beta. DR. Daniel J. Guerra. 06Jan2023. Authentic Biochemistry Podcast Productions 07.01.2023 29:45 ↓

References Connect Tissue Res. 2017 Jan; 58(1): 49–63 J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161

Cytoepigenetics XI. The Treg essential linneage specific transcription factor FOXp3 promoter is regionally variably demethylated and acetylated to control Th immunosuppression.DJGPhD.04.Jan.23. 04.01.2023 30:00 ↓

References Front. Immunol. 2015. 6: 493. Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55

Epistemological integration into realized metaphysics III. Mensam de phaenomenus and the concept of evidentiary existentialism in research science. DJGPhD.01Jan23.Authentic Biochemistry. 02.01.2023 29:40 ↓

References Anaximander 6th century B.C. Plato-Timaeous 4th century B.C. Kant 1781 Critique of Pure Reason Basic quantum physics notes Dr Guerra Neuroscience lectures  

ImmunoEpigenetics X(A). Inhibtion of histone trimethyl-Lys demethylases as arbiter of controlling human Acute Myeloid Leukaemia (AML). Dr Daniel J. Guerra. 30.12.22. Authentic Biochemistry 31.12.2022 30:00 ↓

References The Journal of Biological Chemistry16/2/2018293: 2422-2437. Anal Cell Pathol (Amst). 2018; 2018: 787.1814 Nature Reviews Drug Discovery. Sep2014, Vol. 13 Issue 9, p673-691 J Cancer Res Clin Oncol. 2018; 144(6): 1065–1077.

Diabetes XXV. Obesity linked disruption of adipose mediated endocrine hormone control over fatty acid turnover from TAG leads to T2D in humans. Dr. Daniel J. Guerra. 3April22.Authentic Biochemistry 30.12.2022 29:59 ↓

References Dr. Guerra lecture materials Progress in Lipid Research Volume 74, April 2019, Pages 145-159

Holiday Ethanol Abuse Lecture I. EtoH ingestion, while intoxicating redox metabolism is also a membrane lipid -protein interacting agent that corrupts inwardly rectifying K voltage gated channels. 30.12.2022 30:00 ↓

References Dr Guerra EtOH lectures PNAS November 5, 2013 vol. 110 no. 45 Alcohol, 2017-12-01, Volume 65, Pages 51-62