Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1332 episodes

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Author

Dr Daniel J. Guerra

Episodes

ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23 16.03.2023 29:22

References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association. 12.03.2023 29:48

References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry. 09.03.2023 29:32

References Antioxidants (Basel). 2023 Feb; 12(2): 274 J Lipid Res. 2016 May; 57(5): 868–881. J Biol Chem. 2007 Jan 12;282(2):1384-96. J. Am. Chem. Soc. 2014, 136, 36, 12624–12630

ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe 08.03.2023 30:00

References Int J Hematol 2022. 116, 828–836 Cancer Immunol Res (2022) 10 (1): 87–107 Front Immunol. 2022; 13: 881191 Nature Reviews Immunology 2018. volume 18, pages 617–634.

ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23. 06.03.2023 28:13

References Biochem J 2012 444(1):105-114 Epigenetics. 2015 May; 10(5): 418–430. Nature Reviews Immunology volume 2018. 18, pages 617–634 

ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast 05.03.2023 29:52

References Genes & Diseases Available online 26 December 2022 Int J Mol Sci. 2021 May; 22(10): 5317 Haematologia 2016. Vol. 101 No. 6  June. Blood (2005) 106 (1): 274–286 Nature Reviews Immunology 2018. volume 18, pages 617–634.

ImmunoEpigenetics XXXX. Transcription factor complex permutaions combine with histone acetylomic and methylomic covalent mofications in T -ALL disease. DJGPhD. 04 March 2023. Authentic Biochemistry. 04.03.2023 29:55

References Nature Reviews Immunology volume 18, pages 617–634 (2018) Genes (Basel). 2021 Aug; 12(8): 1118.

ImmunoEpigenetics XXXIX. T cell acute lymphoblastic leukaemia genetics and epigenetics: the role of chromatin retailoring via histone LYS acetylation/deacetylation event ontology. DJGPhD.3March23 04.03.2023 29:45

References Genes (Basel). 2021 Aug; 12(8): 1118. Nature Reviews Immunology 2018. volume 18, pages 617–634.

ImmunoEpigenetics XXXVIII. Tcell receptor activation and the PIP3/AKT/mTORCI/mTORCII control over cytokine expression:a primer. DJGPhD.2March2023.Authentic Biochemistry Podcast. 03.03.2023 29:45

References Guerra's immunology lectures Experimental & Molecular Medicine volume 51, Article number: 80 (2019) Genes (Basel). 2021 Aug; 12(8): 1118

ImmunoEpigenetics XXXVII. Differential substrates for the Adenylate Cyclase-PKA phosphorylation cascade distributes assymetric inflammatory, hormonal and metabolic sequalae. DJGPhD.01March23. 02.03.2023 29:38

REferences Dr Guerra's graduate biochemistry lectures J Biol Chem. 2013 Mar 8; 288(10): 7137–7146

ImmunoEpigeneticsXXXVI. Tumor-specific methylation respondent transcription of Adenylate Cyclase 2 may be linked to differential cytokine expression controlling T cell activation. DJGPhD.01March23. 01.03.2023 29:57

References Naunyn Schmiedebergs Arch Pharmacol . 2014 Apr;387(4):329-39. J Biol Chem. 2013 Mar 8; 288(10): 7137–7146 J Anim Sci. 1998 Jan;76(1):160-72 Journal of Bone Oncology 2017. Volume 9:  34-40

Immunoepigenetics XXXIV. Methylation signatures in neoplasias1. DJGPhD. Authentic Biochemistry Podcast Productions. 26.2.23 26.02.2023 29:59

References Journal of Bone Oncology 2017. Volume 9, November.  Pages 34-40 Journal of Disease and Global Health 15(3): 22-47, 2022.ISSN: 2454-1842, NLM ID: 101664146 https://www.ikppress.org/index.php/JODAGH/article/view/8023

ImmunoEpigenetics XXXIII. Crisper CAS , small molecule,and LOXP-CRE targeting of SDH/ComplexII decrease Th1 cytokine production: Standard Oxidation Potentials and TCA anapleurotic involvement.DJGPhD. 24.02.2023 29:56

References Nature. 2019 Jul; 571(7765): 403–407 Dr Guerra's lectures

ImmunoEpigeneticsXXXII. Apriori synthesis of the glycolytic/TCA/ETC axis mediating target and endogenous apoptotic control with Th and NK cell activation/proliferation and effector function. DJGPhD. 22.02.2023 29:14

References  Authentic Biochemistry Podcast  Immunoepigenetics lectures XXIX-XXX1 Dr. Guerra's intermediary metabolism and bioenergetics lectures Nature. 2019 Jul; 571(7765): 403–407

ImmunoEpigenetics XXXI. The role of SDH on Complex II electron flow to ubiquinone subsequent to cardiac arrest is associated neuronal PCD similar to Tcell bioenergetic switching during activation. 19.02.2023 30:00

References J of Intensive Care. 2020. volume 8, Article number: 60. Neuroscience. 2018 Nov 21;393:24-32 Cancers 2020, 12(11), 3237 Nature. 2019 Jul; 571(7765): 403–407

Immunoepigenetics XXX.NK lymphoyctes programed tumor cell death by titrating anti-apoptotic BCL proteins with BH3 pro-apoptotic events. DJGPhD. 17.2.23. Authentic Biochemistry Podcast 18.02.2023 29:59

References Cancers (Basel). 2020 Aug; 12(8): 2137. Cell Death Dis. 2020 Jan 2;11(1):5 Cell. 2022. 185. 9. :521-1538.e18

ImmunoEpigenetics XXIX. Apoptosis unthwarted:preventing phosphorylation of RNAPOLII tanks histone acetylation near Mcl enhancer region thus epigenetically inhibiting expression in glioblastoma cells. 16.02.2023 29:52

References Cell Death & Differentiation 2020.27: 3374–3385  Cell Death & Differentiation 2019. 26: 1501–1515 Cancers  2020, 12 (8), 2137.

A Dialectic on Research Scientific Method I. How research questions may be apprehended through the hypothetico-deductive-experimental paradigm. DJGPhD. 14.2.23 14.02.2023 29:48

References Guerra: lectures on research methods

ImmunoEpigenetics XXVIII, Synthesis of epigenetically controlled ferroptosis with Cyto-Toxic T Lymphocyte APC/MHC activated IFN-Gamma induced tumor fatty acyl CoA synthase- lipid peroxide mechanism. 14.02.2023 29:33

References Cancer Cell  2020. 40, Issue 4 , Pages 365-378.e6 Circulation Research. . 2004 May 28;94(10):1318-24. Mol Cell. 2020 Jun 18;78(6):1192-1206.e10 Cell. 2012 Aug 17;150(4):685-96 Cell Death Differ. 2020 May; 27(5): 1660–1676.

Immunoepigenetics XXVII. PKM2 as an epigenetic and metabolic author of cell proliferation leading to tumorigenesis. DJGPhD. 12 Feb 2023. Authentic Biochemistry Podcast 13.02.2023 30:00

References Mol Cell. 2014 Mar 6;53(5):700-9 Mol Cell. 2015 Sep 3;59(5):850-7 Cell & Bioscience 2019.Volume 9 , Article number: 52.

ImmunoEpigenetics XXVI.The repressive deubiquitinase (PR-DUB) inhibits ubiquitinated histone 2A occupancy on SLC7A11 promoter causing cystine starvation and GSH depletion promoting ferroptosis. DJGPhD 11.02.2023 29:59

References Cell Research. 2022. volume 32, pages 687–690 .

ImmunoEpigenetics XXV. Lymphocyte Specific Helicase inhibits ferroptosis while promoting tumorigenesis via fatty acid desaturase gene transcription and subsequent oleic acid formation via CoQ10.DJGPhD 09.02.2023 29:26

References Molecular Cancer 2020. volume 19, Article number: 39.  Adv Exp Med Biol. 2021; 1301:41-57

A Biochemical Partita 7th Movement. The articulation of obesity as arbiter of pathophysiology. DJGPhD. 04Feb23. Authentic Biochemistry. 05.02.2023 29:46

References and Inspiration Dr Guerra lecture notes https://youtu.be/uubKzLxxj1s

A Biochemical Partita 6th Movement. Human bioenergetics and hormonal regulation involving FA beta-oxidation and gluconeogenesis "discourage" glyoxylate cycle molecular evolution a priori. DJGPhD. 04.02.2023 30:00

References and Inspirations Dr Guerra graduate biochemistry lectures https://youtu.be/156u4nV2uGE

A Biochemical Partita 5th Movement. The hepatic Malate Apartate Shuttle combined with the 2-oxoglutarate carrier facilitate reducing power and the OAA carbon source for cytosolic gluconeogenesis. 04.02.2023 29:50

References and Inspirations Dr Guerra's lecture notes-graduate biochemistry https://youtu.be/nP4nBxMtEug