Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Author

Dr Daniel J. Guerra

Episodes

Membrane Biochemistry 71. Intracellular-endomembranous cholesterol trafficking and estrogen biosynthesis is under epigenetic control. DJGPhD.29.10.22.Authentic Biochemistry. 29.10.2022 29:55

References Dr Guerra's lipid lectures Periodicum Biologorum 2011. 113(1):43-49 Obstet Gynecol Sci 2014. v.57(2)

Membrane Biochemistry 70. Ketogenesis and cholesterologenesis are mediated by mitochondrial bioenergetics and the ER+Peroxisomal metabolism of VLCPUFA's via membrane domain event ontology.DJGPhD 27.10.2022 29:58

References J Biol Chem v.298(7); 2022 Jul PMC9207681 Antioxidants (Basel). 2021 Jun 3;10(6):906. Dr Guerra lipid lectures

Membrane Biochemistry 69. Distilled electrochemical potential mediated Inner mitochondrial membrane redox and the introduction to sterol involvement.DJGPhD.27.10.22. Authentic Biochemistry 27.10.2022 30:00

Dr. Guerra's Basic Biochemistry Lecture notes

Membrane Biochemistry 68. Elevatum Hypostasis. Dr Daniel J. Guerra. 22.10.22b Authentic Biochemistry 22.10.2022 29:58

Necessary and sufficient knowledge eo ipso obtaining the communicated telos.

Membrane Biochemistry 67. VDAC oligimerization inhibition can block mitochondria-mediated apoptosis and NLRP3 inflammasome activation. DJGPhD.22.10.22.Authentic Biochemistry. 22.10.2022 29:59

References Immunity 2022 551370-1385.e8DOI: (10.1016/j.immuni.2022.06.007 J Biol Chem. 2016 Nov 25; 291(48): 24986–25003. J of Visualized Experiments . 2013; (81): 50966

Membrane Biochemistry 66. Staph aureus infection, autoimmune disease, biliary cholangitis, and neurodegeneration involve NLRP3 Inflammasome activation with core bioenergetic involvement. DJGPhD. 21.10.2022 29:57

References Dr Guerra's immunology lecture notes J Vis Exp . 2013; (81): 50966 Front Immunol. 2019; 10: 1309. Infect Immun . 2013 Dec; 81(12): 4478–4489. Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8

Membrane Biochemistry 65. The integration of pro-inflammatory signaling from a plenum of molecular membranous events: The NRLP3 Inflammsome. DJGPhD. 19.10.22. Authentic Biochemistry. 20.10.2022 29:43

References Dr Guerra's Immunology lectures Am J Gastroenterol. 2004 Nov;99(11):2147-9. Front Immunol. 2019 Jun 7;10:1309 Nat Rev Gastroenterol Hepatol. 2019 Dec 9 I mmunity Volume 55 Issue 8 Pages 1370-1385.e8 (August 2022) DOI: 10.1016/j.immuni.2022.06.007

Membrane Biochemistry 64. Prelude to Biochemical Metaphysics and the Mitochondrial Membrane Damage Response I. Dr. Daniel J. Guerra.18.10.22.Authentic Biochemistry Podcast 18.10.2022 29:13

References Dr. Guerra's lecture notes I mmunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8.

Membrane Biochemistry 63. The TCR:APC Chemokine receptor Trigger for Cytokine Stimulation. DJGPhD. 16 Oct 2022 Authentic Biochemistry Podcast 17.10.2022 29:51

References Dr Guerra's membrane immune synapse lectures Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1 Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXC...

Membrane Biochemistry 62. The T cell receptor mechanism II. Dr. Daniel J. Guerra. 14.10.22 Authentic Biochemistry 15.10.2022 29:47

Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1 Dr Guerra Membrane lipid lectures

Membrane Biochemistry 61. The Tcell membrane :APC synapse I. Dr Daniel J. Guerra 13.10.22 Authentic Biochemistry 13.10.2022 29:14

References Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1 Seminars in Immunology Volume 13, Issue 2 , April 2001, Pages 129-138

Membrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry. 04.10.2022 29:55

References Dr Guerra's membrane lipid lectures Neuron 2015. Volume 85, Issue 4.Pages 695–702

Membrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic Biochemistry 01.10.2022 29:49

Referewnce Guerra basics lecture

Membrane Biochemistry 58. Cardiolipin biosynthesis involves a PC-linoleic acid requiring maturase and a unique phosphatidylglycerol phosphate phosphatase. DJGPhD.25.9.22.Authentic Biochemistry 26.09.2022 29:59

References Dr Guerra membrane lectures Cell Metab. 2020 Dec 1;32(6):981-995.e7 PNAS  2011.108 (29) 11860-11865 J. Dev. Biol. 2020, 8(2), 10. Chem & Phys of Lipids.2000. June. 106:1-29

Membrane Biochemistry 57. c-Fos osteoclastogenesis and control over acetyl ceramide mediated apoptosis.Dr Daniel J.Guerra.22.9.22 Authentic Biochemistry 22.09.2022 27:51

References Dr Guerra Tumor lectures Nature Reviews Endocrinology 2020.volume 16, pages224–233 J Neurochem. 2006 Nov;99(4):1237-50. doi: 10.1111/j.1471-4159

Membrane Biochemistry 56. Membrane Associated Cholesterol hydroxylation leads to bile acid conjugate- promoting human breast cancer stem cell proliferation. DJGPhD.19.9.22 Authentic Biochemistry. 20.09.2022 29:59

References Dr Guerra's membrane sterol  lecture notes Cells. 2019 Apr; 8(4): 293.

Membrane Biochemistry 55. A phosphoglycerolipid primer. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 16 Sept. 2022. 17.09.2022 29:59

References  Dr Guerra's Lecture notes

Membrane Biochemistry 54. De-phospho TYR cFos doubles the VMax of specific glycolipid and phospholipid biosynthetic enzymes via ER stabilization.Dr Daniel J. Guerra. Authentic Biochemistry.14.9.22 14.09.2022 30:00

References Dr Guerra's lipid and membranes lectures Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014.Volume 1841, Issue 9,  Pages 1241-1246 Onco Targets Ther . 2017;10:5491-5524

Membrane Biochemistry 53. cFos correlates with light-induced retinal membrane retailoring without de novo transcription. Dr Dan Guerra. 13.9.22.Authentic Biochemistry Podcast 13.09.2022 29:31

References Dr Guerra's lecture notes Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014. Volume 1841, Issue 9, Pages 1241-1246

Membrane Biochemistry 52. Epigenetic modifications in pathophysiology and the synthesis of nascent membrane lipid in cell cycle progression. DJGPhD.12Sept22. AUthentic Biochemistry 12.09.2022 29:59

References Dr Guerra's membrane lecture notes Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014. Volume 1841, Issue 9, September  Pages 1241-1246 BioEssays, Volume: 40, Issue: 5, First published: 30 March 2018, DOI: (10.1002/bies.201800007) International Journal of Molecular Sciences. 2015. 16(1):1928-48

Membrane Biochemistry 51. The BRD4 epigenetic reader control over cardiac mitochondrial function via bioenergetic gene expression may be corrupted in oncogenic pharmacotherapy driven BETi. DJGPhD. 08.09.2022 30:00

References Circulation. 2020 Dec 15;142(24):2356-2370. Journal of Biological Chemistry 2016. 291, 23756-23768. Nature Reviews Drug Discovery 2014, Vol. 13 Issue 9, p673-691

Membrane Biochemistry L (50). SCFA's work via membrane free fatty acid receptors through transcription factor Nrf2 to reduce ROS with an epigenetic mark-up.DJGPhD.7Sept22.Authentic Biochemistry. 07.09.2022 29:59

References Nature Reviews Drug Discovery. 2014, Vol. 13 Issue 9, p673-691 Redox Biology 2021.Volume 47, November. 102165

Membrane Biochemistry 49. linking membrane reception and endocrine steroid lipid signaling to disease and longevity.DJGPhD.06Sept22 07.09.2022 29:24

References Redox Biology 2021  Volume 47, November. 102165 Front. Immunol., 26 August 2020

Membrane Biochemistry 48.Coxsackievirus B enterovirus causes myocarditis in young men due to lack of estrogen-receptor-mediated control of mitochondrial fission/fusion & inflammation. DJGPhD.3Sept22 04.09.2022 29:50

References J Virol. 2017 Dec 15; 91(24): e01347-17 Br J Pharmacol. 2014 Apr; 171(8): 1890–1906 European Review for Medical and Pharmacological Sciences 2021; 25: 3762-3771 •Mol Med Rep. 2014 Dec; 10(6): 2811–2818.

Membrane Biochemistry 47. AMPK is regulated by steroid hormone activating kinases and calcium. DJGPhD. 02September2022, Authentic Biochemistry Podcast 02.09.2022 29:31

References Nature Cell Biology, 02 Sep 2011, 13(9):1016-1023 Cell Biochem Biophys. 2015 Jul;72(3):701-7 Int J Mol Sci. 2018 Sep; 19(9): 2753. Sci Signal. 2017 Jan 31; 10(464): eaaf7478.