Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Author

Dr Daniel J. Guerra

Episodes

Holiday Ethanol Use V. EtOH mediated WNT signaling and PLC mediated IP3/DAG induction of protein kinase and Ca2+ mobilization contribute to aberrant transcription and translation corrupting health. 18.12.2022 30:00

References Dr Guerra EtOH lectures Physiol Rev 2016. 96: 1261–1296. Clinical and Molecular Teratology. 2016. Volume 106, Issue 9 Pages 749–760

Holiday Ethanol Use IV. MDH and LDH play essential roles in EtOH mediated corruption of bioenergetics, development, and gene expression during fetal development.DJGPhD.16.12.22 b.Authentic Biochem. 17.12.2022 29:55

References Dr Guerra's EtOH lectures Cells. 2020 Sep; 9(9): 2125.

Holiday Ethanol Use III. In utero fetal cardiac muscle development is corrupted by maternal EtOH exposure via metabolic, bioenergetic and epigenetic means involving fatty acid and folate redox poise. 16.12.2022 30:00

References Dr. Guerra's EtOH lectures Clinical and Molecular Teratology 2016. Volume 106:749–760 Stat Pearls. Embryology and Gastrulation. NIH 2022. https://www.ncbi.nlm.nih.gov/books/NBK554394/

Holiday EtOH Lecture II. Ethanol ingestion permanantly corrupts myelin lipid composition while altering MET and Folate metabolism leading to epigenetic syntactic and semantic chromatin errors.DJGPhD. 14.12.2022 29:51

References Clinical and Molecular Teratology Volume 106, Issue 9 September 2016 Pages 749–760 Alcohol, 2017-12-01, Volume 65, Pages 51-62

Immunoepigenetics VII. MicroRNA mediated feedback control over signalling response toward inflammation.DJGPhD. 10Dec22. Authentic Biochemistry 11.12.2022 30:00

References Arthritis Res Ther. 2021; 23: 19. Frontiers in Immunology.  November 2014. 21(578):1

ImmunoepigeneticsV!. TLR's and TCR's use membrane lipid raft signal transduction to obtain transcription factor mediated cell fate via epigenetic modification. DJGPhD.09 Dec.22 09.12.2022 29:53

References Frontiers in Immunology November 2014. 21(578):1 Clin Epigenetics. 2017; 9: 94  Cancer Cell International September 2020. 20(1):429

ImmunoepigeneticsV. TCR activation and the integration of cell senescence with epigenetic authorship and reading-mediated tumorigenesis. DJGPhD.07Dec22. Authentic Biochemistry 07.12.2022 29:52

References Cancer Cell Int. 2022; 22: 272. Cell Mol Life Sci. 2013 Oct;70(20):3753-72 PLoS Biol. 2013 Mar; 11(3): e1001502

ImmunoEpigeneticsIV. Membrane lipid raft components dynamically mediate Tcell reception, hippocampal pyrimidal neuron endocytosis, and lung cancer cell mesenchymal to endothelial transition.DJGPhD. 05.12.2022 29:28

References Respir Res. 2017 Sep 6;18(1):168 Front Behav Neurosci. 2020; 14: 24 JLR Methods| 2020.Volume 61, ISSUE 11, P1512-1523, November 01

Immunoepigenetics 3. EtOH abuse interrupts membrane lipid raft -mediated TCR signaling by decreasing the TF NFAT nuclear translocation and IL-2 transcription.DJGPhD.04.DEC.22.Authentic Biochemistry. 04.12.2022 29:08

Reference Alcohol Clin Exp Res. 2011 Aug; 35(8): 1435–1444

Immunoepigenetics 2. Treg and ILC differentiation and the evolution of lymphocytic response specificity incl. B cell class switch recombination and somatic hypermutation deamination.DJGPhD.2.12.22 02.12.2022 30:00

References Advances in Immunology. 2011 v.109.Pp125 Biomed J. 2014 Sep-Oct;37(5):269-83 Alcohol Clin Exp Res. 2011 Aug; 35(8): 1435–1444 Cell Reports 10, 2043–2054, March 31, 2015 Front. Immunol., 28 September 2015 | https://doi.org/10.3389/fimmu.2015.00493 Front. Immunol., 07 January 2021 Sec. T Cell Biology https://doi.org/10.3389/fimmu.2020.609891

Membrane Biochemistry 86/Immunoepigentics1. The complex divergent roles of Inhibitor of DNA (Id) binding proteins in terminal differentiation and disease states. DJGPhD.01.12.22.Authentic Biochemistry 02.12.2022 30:01

References Cell Reports Volume 17, Issue 11, 13 December 2016, Pages 2827-2836 Cardiovascular Research, cvac159, https://doi.org/10.1093/cvr/cvac159.Published:27 September 2022 Cancer Med. 2012 Oct; 1(2): 176–186. Nat Immunol. 2011 Nov 6; 12(12): 10 Nat Immunol. 2014 Aug; 15(8): 767–776 Stem Cells. 2007 Feb;25(2):500-10.

Membrane Biochemistry 85. EBV latent membrane protein induction of haemopoietic proliferative disease and Id repressor protein transcriptionally mediated terminal differentiation.DJGPhD.30.11.22. 30.11.2022 29:58

References Stem Cell Reviews and Reports volume 17, pages 1486–1499 (2021) BMC Cancer. 2008 Dec 19;8:379 Curr Top Microbiol Immunol. 2015;391:119-49.

Membrane Biochemistry 84. Isolation of membrane protein using non-ionic detergents exposes the prescence of cellular lipid raft domains. DJGPhD. 29.11.22. Authentic Biochemistry. 30.11.2022 29:56

References Methods Mol Biol. 2021; 2268: 1–20

Membrane Biochemistry 83. Countercurrent distribution theory of membrane lipid raft mediated endomebranous sequence ontology. DJGPhD.26.11.22 26.11.2022 29:59

Referernces Dr. Guerra's deductive reasoning

Membarne Biochemistry 82. Coda in absentia. Redux of the epistemological lens and the membrane lipid raft resurfaces. Dr. Daniel J. Guerra. 23.11.22. Authentic Biochemistry Podcast 23.11.2022 29:52

References Timaeus, Plato Dr Guerra's thoughts and lectures N Engl J Med 2005;353:604-15

Membrane Biochemistry 81. Synopsis. Logical judgment and square of opposition applied to lipids as transcription factors and membrane sequence derivatives respectively. DJGPhD19.11.22.Authentic Bioch 19.11.2022 29:59

References Dr Guerra's unpublished writings

Membrane Biochemisty.Steroidogenic endo-nuclear sphingolipid metabolism involving ganglioiside turnover mediates transcription factor de-repression via DAG kinase.DJGPhD.18.11.22. 19.11.2022 30:00

References Dr Guerra's  lipid lectures Front Pharmacol. 2020; 11: 569802 B iomolecules 2022 , 12 (10), 1434; https://doi.org/10.3390/biom12101434

Membrane Biochemistry 79. Sphingolipids and cyclic phosphatidic acid control PPAR isoform-mediated gene transcription over lipid metabolism and inflammation. DJGPhD.16.11.22. Authentic Biochemistry 16.11.2022 29:49

References Circulation Research. 2008;102:283–294 Neurochemical Research volume 45, pages 972–988 (2020) Biochim Biophys Acta. 2008 Sep; 1781(9): 519–524.

Membrane Biochemistry 78. Nuclear sphingolipid metabolism controlling cAMP response element-mediated transcription promoting proinflammation and anti-inflammation temporally and spatially.DJGPhD. 15.11.2022 29:46

References Nature Scientific Reports 2017.volume 7, Article number: 18004  Cells 2022, 11(13). https://doi.org/10.3390/cells11132020 European Journal of Endocrinology 2015. (July). 173(4). Front Pharmacol. 2020; 11: 569802.

Membrane Biochemistry 77. Membrane lipid mediated IGF-I in contextual expression within discrete organ systems controls an inflammatory valence DJGPhD. 9 November 2022 Authentic Biochemistry 10.11.2022 29:40

References Front Aging Neurosci. 2017; 9: 365 J Physiol Biochem. 2017; 73(2): 245–258 Annu Rev Physiol. 2012; 74: 131–151.

Membrane Biochemistry 76. Introduction to SubCellular-Distribution Mechanisms and Function of Nuclear-Localized Lipids. DJGPhD.06Nov22b.Authentic Biochemistry Podcast 06.11.2022 29:57

References Dr Guerra lecture notes Annu Rev Physiol. 2012; 74: 131–151.

Membrane Biochemistry75. Rational judgment as the epistimological prolegomena to research science:isoprenoid lipid biosynthesis guided event ontologies.DJGPhD.6NOV22.Authentic Biochemistry. 06.11.2022 30:00

Dr Guerra's Lecture notes 

Membrane Biochemistry 74. ER-Phosphatidylcholine biosynthesis regulates neuritigenesis and the use of logical judgment in research science. DJGPhD. 03Nov22. Authentic Biochemistry 03.11.2022 29:56

References PLoS One. 2019 Jan 10;14(1):e0210207 Nature Communications volume 9, Article number: 1784 (2018)) Cell Death & Disease volume 8, page e2897; 2017 Nat Cell Biol. 2013 Apr;15(4):373-84 Dev Neurobiol. 2010 Jul; 70(8): 589–603 J. Lipid Res. (2022) 63(8) 100213

Membrane Biochemistry 73. Pathogenic membrane associated phosphatidylcholine and sphingomyelin metabolism is linked to skeletal and CNS pathology. DJGPhD.02NOV22. Authentic Biochemistry 02.11.2022 30:00

References J. Lipid Res. (2022) 63(8) 100213 Front. Cell Dev. Biol., 15 October 2019  Bortlein et al. Cell Death & Disease. 2016.  volume 7, page e2488 J. Biol. Chem. 1998;273:14550-14559

Membrane Biochemistry72. DHEA and the steroidogenic pathways as biochemical prolegomena to logical judgments. Dr. Daniel J. Guerra.29.10.22b.Authentic Biochemistry 29.10.2022 29:51

References Dr Guerra's lipid biochemistry lectures Int. J. Mol. Sci. 2019, 20, 4660; doi:10.3390/ijms20194660