Authentic Biochemistry

ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23 25.06.2023 28:50 ↓

References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Sci Signal. 2015 Mar 31;8(370):re4

ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD. 24.06.2023 29:43 ↓

References J Exp Med. 2017 Jul 3;214(7):1861-1876 Immunol Rev. 2014 Sep;261(1):62-83 Int J Mol Sci. 2022 Mar; 23(5): 2878. Immunity 2022. Volume 55, Issue 8. :1402-1413.e4

ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast 23.06.2023 30:00 ↓

References Guerra: logical propositions and dialectical syntheses Annual Review of Immunology2021. Volume 39: 279-311

ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD 23.06.2023 29:17 ↓

References Nat Protoc. 2017 Nov;12(11):2342-2354 Annual Review of Immunology 2021. Volume 39. pp 279-311 Immunity 2022. Volume 55, Issue 8. Pages 1402-1413.e4

ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD. 22.06.2023 30:00 ↓

References Immunity 2022. 55, Issue 8. Pages 1402-1413. Methods Mol Biol. 2018;1675:167-181. Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Cell Reports 2015 10, 2043-2054DOI: (10.1016/j.celrep.2015.02.057)

ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23 18.06.2023 30:00 ↓

Reference Authentic Biochemistry Lecture synthesis

ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry 17.06.2023 29:50 ↓

Reference J BiolChem. 2023 Mar; 299(3): 103019.

ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast 16.06.2023 29:50 ↓

References J Biol Chem 2017 292: 20481. Critique if Pure Reason.1781. Kant,I. Guerra,2023. manuscripts in preparation

ImmunoEpigenetics77. T cell membrane phospholipase D mediated PA deprotonation as a biosensor for an electrostatic/hydrogen-bond signal transductionDJGPhD.15.6.23. Authentic Biochemistry Podcast. 16.06.2023 28:46 ↓

References The Journal of Biological Chemistry 2007.282,11356-11364. BMC Biology 2011. 9:85 Cancer Res . 2011 Jan 15;71(2):293-7. J BiolChem. 2023 Mar; 299(3): 103019.

Interum lecture VI. Entropic forces and the ergodic hierarchy of GPCR-linked phsopholipase phase space postioning temporality. DJGPhD.13.6.23 14.06.2023 29:47 ↓

References ACS Omega. 2019 Nov 26; 4(22):19526–19547 Guerra: general thermodynamics lectures

Interum Lecture V. Semi-closure on free energy and enthalpic involvement in leptin/AMPK mediated orexigenic states . DJGPhD.12June23.Authentic Biochemistry Podcast 12.06.2023 29:49 ↓

Reference Guerra lecture material

Interum Lecture IV. MBD:DNAMolecular Dynamics video lecture! 12.06.2023 1:07 ↓

https://youtu.be/O2CpwFLy0zI

Interum Lecture III. Protein methylation binding domain association with substrate CpG alters equilibrium torsion angle (epsilon-zeta) conformational states via enthalpic-free energy conservation. 11.06.2023 29:57 ↓

References Mol Informatics. 2012 Feb;31(2):114-22. Nat Struct Mol Biol. 2017 Jun; 24(6):544–552 Guerra: chemical thermodynamics lectures

Interum Lecture II. Rates of reactions in living systems.DJGPhD.8June2023 Authentic Biochemistry Podcast 09.06.2023 30:00 ↓

References Guerra-lecture notes and marginalia

Interrum lecture I. Obesity unsuccessfully violates the first law of thermodynamics. 07.06.2023 30:00 ↓

References Guerra: Faculties of reason

ImmunoEpigenetics 76. Sphingolipid metabolism and S1P receptor expression linked to multiple potentiating immunoinflammatory obese associated pathophysiologies. DJGPhD.6June23B AuthenticBiochemistry 07.06.2023 29:13 ↓

References Dr. Guerra-graduate lipid lectures Nutrients.2022 Jun 12;14(12):2438 Endocrinology. 2006 Dec;147(12):5835-44 The International Journal of Biochemistry & Cell Biology 2019. Volume 114, 105564

ImmunoEpigenetics 75. Sphingolipid receptor molecular discernment from exosome cargo mediated control involves M1 to M2 polarization shift post myocardial infarction induced fibrosis. DJGPhD.6June23 06.06.2023 30:00 ↓

Reference The International Journal of Biochemistry& Cell Biology Volume 114, 105564.

ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion 05.06.2023 30:00 ↓

References JCI Insight. 2016 Nov 17; 1(19): e87748. Graduate Biochemistry lecture archives-Guerra Nutrition. 2020 Oct;78:110935.

ImmunoEpigenetics 73. The dialectical synthesis of adipose PPAR-gamma mediated fatty acid binding protein4 expression in foam cell formation and subsequent adipokine contribution to insulin secretion 05.06.2023 29:42 ↓

References Cells. 2019 Mar; 8(3): 227 Chest. 2016 Jul; 150(1): 91–101 JCI Insight. 2016 Nov 17; 1(19): e87748.

ImmunoEpigenetics72. Chemistry of reactive oxygen/nitrogen radical species as adipose pathobiochemical sequalae to obesity via M1 macrophage polarity involving adipose and vasculature pathophysiology. 03.06.2023 29:46 ↓

References Inn Med (Heidelb). 2023 Apr;64(4):313-322 JBC 2001.Volume 276, Issue 31, Pages 28799-28805 Frein, Daniel. 2006. “Signaling and Redox Regulation by Nitric Oxide, Superoxide and Carbon Monoxide.” Hypertension. 2002;39:1088–1094 Nat Metab. 2022 Sep;4(9):1202-1213 JCI Insight. 2016 Nov 17; 1(19): e87748

ImmunoEpigenetics 71. Insulin receptor corruption is mediated by high circulating fatty acids, in situ DAG-PKCepsilon induced phosphorylation and membrane protein aggregation in obese diabetics.DJGPhD 02.06.2023 26:34 ↓

References Guerra Biochemistry lecture archives Nat Metab. 2022 Sep;4(9):1202-1213 Mol Cell. 2008 May 23; 30(4): 403–414 J Clin Invest. 2016 Nov 1; 126(11):4361–4371. Front Immunol. 2021; 12: 746151.

ImmunoEpigenetics 70.Obesity-linked adipose resident macrophage (M1)polarization meta-inflammation leads to Insulin Resistance via fatty acid oxygenation in situ. DJGPhD.01June2023.Authentic Biochem. 02.06.2023 29:36 ↓

References Graduate Biochemistry lectures-Guerra Front Immunol. 2021; 12: 746151

Intermediary Metabolism Lecture. Covalent modification of enzymes and transcription factors alter bioenergetics and the pro-inflammatory response in obese vs. healthy patients.31.5.23 DJGPhD 31.05.2023 29:53 ↓

References Guerra general graduate biochemistry lecture Immunol Res. 2020 Feb;68(1):28-38. doi: 10.1007/s12026-020-09125-9.

See the youtube video in the show notes 26.05.2023 1:28 ↓

https://youtu.be/es0RrQHHXl0

ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency. 25.05.2023 30:00 ↓

References Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303. Protein Cell. 2021 Apr; 12(4): 240–260. J Cell Biol (2022) 221 (11): e202202011.