Authentic Biochemistry

ImmunoepigeneticsXXI. Methylation patterns of CpG vs histone modification of specific loci must be sequenced to verify pathophysiological events. DJGPhD. 22.1.23 Authentic Biochemistry. 22.01.2023 29:59 ↓

References Hum Genomics. 2021; 15: 24 JCI Insight. 2020 Sep 3;5(17):e138443 N ature Reviews Genetics volume 14 , pages 204–220 (2013)

A Special Message for Authentic Biochemists. A direct way to contact your host and a little more. DJGPhD.21.1.23 Authentic Biochemistry Productions. 21.01.2023 10:36 ↓

Rather than referencing this episode I am enlisting your input. Please email me at our new email address: authenticbiochemistry@gmail.com   Sincerely, Dr Guerra

Immunoepigenetics XX. Inflammatory cytokines and associated transcription factors are controlled by epigenetically regulated microRNA. DJGPhD.20.1.23. Authentic Biochemistry. 21.01.2023 29:49 ↓

References Dr Guerra's micro RNA lectures FEBS J Volume278, Issue10 May 2011. Pages 1598-1609 International Journal of Molecular Sciences 2013. 14(11):22796-22816  Front. Genet., 07 September 2021

ImmunoEpigeneticsXIX. Diet-induced and db/db mouse model Type 2 diabetes is dissimilar to the human pathophysiology but shares epigenetic mechanisms controlling pro-inflammatory PLA2/COX2/PGE2. 20.01.2023 29:58 ↓

References Dr. Guerra's lipid lectures JCI Insight. 2020 Sep 3;5(17):e138443 Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7): 4061–4065.

ImmunoepigeneticsXVIII. Variable DNA and histone methylation in cooperation with micro RNA mediate macrophage plasticity,inflammation and wound repair in T2D patients. DJGPhD.18.1.23.AuthenticBiochem. 19.01.2023 30:00 ↓

Reference JCI Insight . 2020 Sep 3;5(17):e138443

Epistemological integration into realized metaphysicsV. Energy and mass like space and time are estimations of uncertain certainties yet are used as universals in physico-chemical event ontologies 16.01.2023 30:00 ↓

References Thomas Hobbs-Leviathan Heraclitus-Collected Works

Immunoepigenetics XVII.TGF beta involvement in disease pathology and normal developmental physiology demonstrates the complexity of categorical ontologies in biochemical events.DJGPhD.13.1.23.AB 14.01.2023 29:56 ↓

References JCI Insight . 2020 Sep 3;5(17):e138443 J Clin Invest. 2022 Apr 15;132(8):e151020

ImmunoepigeneticsXVI. TGFbeta 1 and subfamily member Activin A diferentially alter the categorical valence and modality of Th17 cells in multiple sclerosis via receptor kinase modulatory specificity. 13.01.2023 30:00 ↓

References Immunity. 2021 Feb 9; 54(2): 308–323.e6. J Endocrinol. 2003 Sep;178(3):479-89.

ImmunoepigeneticsXV. In utero fetal exposure to high concentration of maternal cortisol can induce histone code hypomethylation proximal to the TGF B-1 receptor resulting in adult OA.DJGPhD.12Jan23 13.01.2023 29:51 ↓

References Stem Cell Res Ther. 2021; 12: 163 Biomedicines. 2021 Nov; 9(11): 1666

ImmunoepigeneticsXIV. Epithelial cell metabolism and the potential transition to mesenchyma is regulated by TGF-Beta and linked to ALK-1 receptor associated OA. DJGPhD.11Jan23.Authentic Biochemistry. 11.01.2023 30:00 ↓

References Clin Podiatr Med Surg . 2001 Jan;18(1):35-53 Biomedicines. 2021 Nov; 9(11): 1666

Biochemical Consequences of Sensorial Phenomenology V. The possibility of Necessary biological modality . DJGPhD. 09Jan23. Authentic Biochemistry. 10.01.2023 29:57 ↓

References A plenum of  time.

ImmunoepigeneticsXIII. The interplay of NFKappB and articular cartilage glycosaminoglycan metabolism in regulating pro-inflammatory cytokine expression in OA. DJGPhD.Authentic Biochemistry. 08Jan2023 08.01.2023 29:17 ↓

references J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161 Connect Tissue Res. 2017 Jan; 58(1): 49–63.

ImmunoepigeneticsXII. Osteo-Arthritis 1. Clinical manifestation and the role of TGF-Beta. DR. Daniel J. Guerra. 06Jan2023. Authentic Biochemistry Podcast Productions 07.01.2023 29:45 ↓

References Connect Tissue Res. 2017 Jan; 58(1): 49–63 J. Funct. Morphol. Kinesiol. 2016, 1(2), 154-161

Cytoepigenetics XI. The Treg essential linneage specific transcription factor FOXp3 promoter is regionally variably demethylated and acetylated to control Th immunosuppression.DJGPhD.04.Jan.23. 04.01.2023 30:00 ↓

References Front. Immunol. 2015. 6: 493. Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55

Epistemological integration into realized metaphysics III. Mensam de phaenomenus and the concept of evidentiary existentialism in research science. DJGPhD.01Jan23.Authentic Biochemistry. 02.01.2023 29:40 ↓

References Anaximander 6th century B.C. Plato-Timaeous 4th century B.C. Kant 1781 Critique of Pure Reason Basic quantum physics notes Dr Guerra Neuroscience lectures  

ImmunoEpigenetics X(A). Inhibtion of histone trimethyl-Lys demethylases as arbiter of controlling human Acute Myeloid Leukaemia (AML). Dr Daniel J. Guerra. 30.12.22. Authentic Biochemistry 31.12.2022 30:00 ↓

References The Journal of Biological Chemistry16/2/2018293: 2422-2437. Anal Cell Pathol (Amst). 2018; 2018: 787.1814 Nature Reviews Drug Discovery. Sep2014, Vol. 13 Issue 9, p673-691 J Cancer Res Clin Oncol. 2018; 144(6): 1065–1077.

Diabetes XXV. Obesity linked disruption of adipose mediated endocrine hormone control over fatty acid turnover from TAG leads to T2D in humans. Dr. Daniel J. Guerra. 3April22.Authentic Biochemistry 30.12.2022 29:59 ↓

References Dr. Guerra lecture materials Progress in Lipid Research Volume 74, April 2019, Pages 145-159

Holiday Ethanol Abuse Lecture I. EtoH ingestion, while intoxicating redox metabolism is also a membrane lipid -protein interacting agent that corrupts inwardly rectifying K voltage gated channels. 30.12.2022 30:00 ↓

References Dr Guerra EtOH lectures PNAS November 5, 2013 vol. 110 no. 45 Alcohol, 2017-12-01, Volume 65, Pages 51-62

ImmunoEpigeneticsIX. Promoter/Enhancer proximal and distal epigenetic signatures and transcription factor protein heterogeneity compose gene expression event ontology.DJGPhD.29.12.22.AuthenticBiochem 29.12.2022 29:54 ↓

References Proc Natl Acad Sci U S A. 2021 Nov 16; 118(46) Nat Rev Mol Cell Biol. 2021 Dec 1; 22(12): 815–833. 

More "mere" epistemology opening a door to metaphysics II. Non-canonical epi-rational and epi-empirical retailoring of understanding and imagination via research scientific endojectification.DJGPhD. 25.12.2022 24:42 ↓

References Dr. Guerra's ongoing flight into the telos of research science.

ImmunoepigeneticsVIII. Protective immunotolerant neonate Th1 inactivity involves IL-12 p35subunit promoter methylation. DJGPhD.23.12.22. Authentic Biochemistry Podcast 24.12.2022 29:54 ↓

References Trends in Immunology. REVIEW. 2017. VOLUME 38, ISSUE 4, P287-297. J Biomed Sci. 2014 Aug 19;21(1):76.

Holiday Ethanol Use VIII. EtOH induced cAMP /CREB associated PKA kinase driven phosphorylation cascade co-opts the TLR4-mediated neuroinflammatory/neurotoxic CNS-microglial axis.DJGPhD.22.12.22.AB. 23.12.2022 30:00 ↓

References Neural Plasticity. 2019; 2019: 1648736. Molecular Pharmacology May 2017, 91 (5) 451-463.

Holiday Ethanol Use VII. EtOH exposure precipitates chromatin methylation associated MCH and chemokine involvement linking arousal, reward and inflammation. DJGPhD.21.12.22 Authentic Biochem. 21.12.2022 29:58 ↓

References PLoS One. 2011;6(5):e17711 J Neuroinflammation. 2020; 17: 207 Front Neurosci. 2019 Nov 26;13:1280

Mere Epistemology Knocking on Metaphysics for a late December Evening. I. DJGPhD.21 December 2022 Authentic Biochemistry Podcast 21.12.2022 21:15 ↓

References Dr Guerra's ideas and concepts concerning the epistemics of research science . Lecture I.

Holiday Ethanol Use VI. EtOH associated DNA methylation of neurotransmitter systems opens the door to neurotoxicity and cognitive deficits. DJGPhD.18.12.22b. Authentic Biochemistry Podcast 18.12.2022 30:00 ↓

References Dr Guerra EtOH lectures Dr Guerra Reward Pathway lectures Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Biochemistry and Cell Biology. 2019. Volume 97, Number 4.August.