Authentic Biochemistry

ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast 16.06.2023 29:50 ↓

References J Biol Chem 2017 292: 20481. Critique if Pure Reason.1781. Kant,I. Guerra,2023. manuscripts in preparation

ImmunoEpigenetics77. T cell membrane phospholipase D mediated PA deprotonation as a biosensor for an electrostatic/hydrogen-bond signal transductionDJGPhD.15.6.23. Authentic Biochemistry Podcast. 16.06.2023 28:46 ↓

References The Journal of Biological Chemistry 2007.282,11356-11364. BMC Biology 2011. 9:85 Cancer Res . 2011 Jan 15;71(2):293-7. J BiolChem. 2023 Mar; 299(3): 103019.

Interum lecture VI. Entropic forces and the ergodic hierarchy of GPCR-linked phsopholipase phase space postioning temporality. DJGPhD.13.6.23 14.06.2023 29:47 ↓

References ACS Omega. 2019 Nov 26; 4(22):19526–19547 Guerra: general thermodynamics lectures

Interum Lecture V. Semi-closure on free energy and enthalpic involvement in leptin/AMPK mediated orexigenic states . DJGPhD.12June23.Authentic Biochemistry Podcast 12.06.2023 29:49 ↓

Reference Guerra lecture material

Interum Lecture IV. MBD:DNAMolecular Dynamics video lecture! 12.06.2023 1:07 ↓

https://youtu.be/O2CpwFLy0zI

Interum Lecture III. Protein methylation binding domain association with substrate CpG alters equilibrium torsion angle (epsilon-zeta) conformational states via enthalpic-free energy conservation. 11.06.2023 29:57 ↓

References Mol Informatics. 2012 Feb;31(2):114-22. Nat Struct Mol Biol. 2017 Jun; 24(6):544–552 Guerra: chemical thermodynamics lectures

Interum Lecture II. Rates of reactions in living systems.DJGPhD.8June2023 Authentic Biochemistry Podcast 09.06.2023 30:00 ↓

References Guerra-lecture notes and marginalia

Interrum lecture I. Obesity unsuccessfully violates the first law of thermodynamics. 07.06.2023 30:00 ↓

References Guerra: Faculties of reason

ImmunoEpigenetics 76. Sphingolipid metabolism and S1P receptor expression linked to multiple potentiating immunoinflammatory obese associated pathophysiologies. DJGPhD.6June23B AuthenticBiochemistry 07.06.2023 29:13 ↓

References Dr. Guerra-graduate lipid lectures Nutrients.2022 Jun 12;14(12):2438 Endocrinology. 2006 Dec;147(12):5835-44 The International Journal of Biochemistry & Cell Biology 2019. Volume 114, 105564

ImmunoEpigenetics 75. Sphingolipid receptor molecular discernment from exosome cargo mediated control involves M1 to M2 polarization shift post myocardial infarction induced fibrosis. DJGPhD.6June23 06.06.2023 30:00 ↓

Reference The International Journal of Biochemistry& Cell Biology Volume 114, 105564.

ImmunoEpigenetics74.The methylation-specific epigenetic control over adipose tissue macrophage polarity is axially supported by leptin induced CNS control over satiety and pancreatic insulin secretion 05.06.2023 30:00 ↓

References JCI Insight. 2016 Nov 17; 1(19): e87748. Graduate Biochemistry lecture archives-Guerra Nutrition. 2020 Oct;78:110935.

ImmunoEpigenetics 73. The dialectical synthesis of adipose PPAR-gamma mediated fatty acid binding protein4 expression in foam cell formation and subsequent adipokine contribution to insulin secretion 05.06.2023 29:42 ↓

References Cells. 2019 Mar; 8(3): 227 Chest. 2016 Jul; 150(1): 91–101 JCI Insight. 2016 Nov 17; 1(19): e87748.

ImmunoEpigenetics72. Chemistry of reactive oxygen/nitrogen radical species as adipose pathobiochemical sequalae to obesity via M1 macrophage polarity involving adipose and vasculature pathophysiology. 03.06.2023 29:46 ↓

References Inn Med (Heidelb). 2023 Apr;64(4):313-322 JBC 2001.Volume 276, Issue 31, Pages 28799-28805 Frein, Daniel. 2006. “Signaling and Redox Regulation by Nitric Oxide, Superoxide and Carbon Monoxide.” Hypertension. 2002;39:1088–1094 Nat Metab. 2022 Sep;4(9):1202-1213 JCI Insight. 2016 Nov 17; 1(19): e87748

ImmunoEpigenetics 71. Insulin receptor corruption is mediated by high circulating fatty acids, in situ DAG-PKCepsilon induced phosphorylation and membrane protein aggregation in obese diabetics.DJGPhD 02.06.2023 26:34 ↓

References Guerra Biochemistry lecture archives Nat Metab. 2022 Sep;4(9):1202-1213 Mol Cell. 2008 May 23; 30(4): 403–414 J Clin Invest. 2016 Nov 1; 126(11):4361–4371. Front Immunol. 2021; 12: 746151.

ImmunoEpigenetics 70.Obesity-linked adipose resident macrophage (M1)polarization meta-inflammation leads to Insulin Resistance via fatty acid oxygenation in situ. DJGPhD.01June2023.Authentic Biochem. 02.06.2023 29:36 ↓

References Graduate Biochemistry lectures-Guerra Front Immunol. 2021; 12: 746151

Intermediary Metabolism Lecture. Covalent modification of enzymes and transcription factors alter bioenergetics and the pro-inflammatory response in obese vs. healthy patients.31.5.23 DJGPhD 31.05.2023 29:53 ↓

References Guerra general graduate biochemistry lecture Immunol Res. 2020 Feb;68(1):28-38. doi: 10.1007/s12026-020-09125-9.

See the youtube video in the show notes 26.05.2023 1:28 ↓

https://youtu.be/es0RrQHHXl0

ImmunoEpigenetics 69. Lipoprotein and cargo cholesterol in the epigenetic regulation of the tumor microenvironment secreted pleckstrin convertase corrupting CD8+ Tcell cholesterol uptake and potency. 25.05.2023 30:00 ↓

References Journal of Experimental & Clinical Cancer Research 2022.volume 41, Article number: 303. Protein Cell. 2021 Apr; 12(4): 240–260. J Cell Biol (2022) 221 (11): e202202011.

Graduate Biochemistry Lecture III. Dietary lipid control over neuroendocrine system involves multiple organ systems in contact with immune surveilance. DJGPhD. 24.5.23B Authentic Biochemistry 24.05.2023 29:53 ↓

References Dr. Guerra's lecture archives.

Graduate Biochemistry Lecture.II. Lipid digestion and enterocyte localized neuroendocrine secretion proximal to chylomicron assembly.Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23. 24.05.2023 29:59 ↓

References Dr. Guerra's lipid lectures J Diabetes Investig. 2019 Nov; 10(6): 1430–1437.

Special Graduate Biochemistry Lecture! Lipoproteins I. Dr Daniel J. Guerra. Authentic Biochemistry Podcast 19.5.23. 20.05.2023 29:40 ↓

Reference Dr Guerra: Graduate Biochemistry lecture material.

ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters 18.05.2023 29:59 ↓

References Arterioscler Thromb Vasc Biol . 2021 Jan;41(1):153-166. Clinical Epigenetics 2021. volume 13, Article number: 7. https://www.sciencedirect.com/topics/immunology-and-microbiology/foam-cell

ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD 16.05.2023 29:53 ↓

References JLR 2014 55(6) Pages 1165-1172. JLR 2018 59(6): 1058–1070.

ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD. 16.05.2023 29:49 ↓

References PLoS ONE 2012. 7(4): e3440 Steroids 2021. Volume 172, August, 108854 Antioxidants 2019, 8(5), 126

ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis. 14.05.2023 30:00 ↓

References Free Radical Biology and Medicine Volume 71, June. Pages 1-15 Cardiovasc. Res. 2012 May 1; 94(2): 379–390. Int. J. Mol. Sci. 2020, 21 (7), 2578; https://doi.org/10.3390/ijms21072578