Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1331 episodes

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Author

Dr Daniel J. Guerra

Episodes

BioMedical Portrait V.c8. NOX2 subunitorganization, oxygen availability and phase I discussion of glycolytic allosteric control.DJGPhD.01Nov23 01.11.2023 30:00

References FASEB 2017. Volume 31, Issue2 Pages 663-673 Guerra,DJ. Graduate Biochemistry Lectures Albioni , Thomaseo. 1708. Sonate da chiesa ("op. 4") (for violin and basso continuo), https://youtu.be/IMmjjcfG2c4?si=C4VG-rPWL_Fv7-Xe

BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31 01.11.2023 30:00

References Eur J Microbiol Immunol (Bp). 2011 Mar;1(1): 41–58 J Periodontal Res. 2018 Jun; 53(3):403–413. DJGPhD lecture notes

BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and 01.11.2023 29:59

References J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612 Biomaterials. 2020 Apr; 238: 119836. Int J Nanomedicine . 2023;18:5265-5287 Child Ballad 100. 1775. Pentangle. 1972.Willie O' Winsbury https://youtu.be/nwqP_yoszCE?si=C0NH51euOOTlPYn9

BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b. 30.10.2023 30:00

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2):S135–S139. J Oral Microbiol. 2017; 9(1): 1400858

BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD 29.10.2023 30:00

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2): S135–S139. J Oral Microbiol. 2017; 9(1): 1400858. J Dent Res. 2020 Jun;99(6):644-649. Mozart WA 1782. D major, K. 385. Symphony 35 (Haffner)

BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23 27.10.2023 29:50

References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Gut Microbes. 2022; 14(1): 2073785. Adv Exp Med Biol. 2020:1263:13-23 Bredon, Anne. 1950. Led Zepplin. 1969. https://youtu.be/dZitPJMh60A?si=MnEpM-iemNFWEKE7

BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion. 26.10.2023 30:00

References Blood (2004) 103 (11): 3993–3994 Anticancer Agents Med Chem. 2023;23(3):256-265 Med Hypotheses. 2021 Jan:146:110466.

BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint. 24.10.2023 29:56

References Cell. 2021 Aug 19;184(17):4480-4494.e15 Sci Rep. 2019 Mar 5;9(1):3433 Med Hypotheses. 2021 Jan:146:110466. Hayward, J. 1967. Moody Blues. "Tuesday Afternoon" https://youtu.be/jmMPBQ4kYKk?si=X0UyZJFq2AAnKSvJ

Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast 23.10.2023 29:59

Send an email to authenticbiochemistry@gmail.com with comments.

All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry 23.10.2023 29:59

Vide supra.

BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast 22.10.2023 30:00

References Cureus. 2022. 14(9): e29696.doi:10.7759/cureus.29696 NMR Biomed. 2021 Feb;34(2):e4448. NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Nutrients. 2023 May; 15(9): 2029. Mozart, WA. 1791 K 626 Requiem in d minor.

BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry. 19.10.2023 30:00

References Mol Cell Neurosci. 2012 Jan; 49(1): 44–53 NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5092–5094.

BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast 18.10.2023 30:00

References Brain. 2023 Sep 13:awad309. doi: 10.1093/brain/awad309 J Alzheimers Dis. 2016 Feb 26;52(1):43-50. Haydn, FJ. 1796. MISSA IN TEMPORE BELLI https://youtu.be/8_5tgmAwN-E?si=AYzyMMk47b2IUt0Y Send an email to Dr Guerra! authenticbiochemistry@gmail.com

BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD. 17.10.2023 29:55

References Brain. 2023 Sep 13:awad309 McBroom, Amanda. 1970 "the Rose" httBps://youtu.be/cO59ITNCxzk?si=v-qx_2_mPq3zbCYH

BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry. 17.10.2023 30:00

References Front. Immunol., 19 October 2022 Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309

BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast 16.10.2023 30:00

References Schubert, F. 1820. Rosamunde Overture. https://youtu.be/3Pc_LUItWQI?si=ZB3bsrmz3ReiJQdi Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309.

BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23 14.10.2023 28:45

Mol Cell Biol. 2012 Jan;32(1):126-38 Mutat Res. 2013 Jul-Sep;753(1):24-40 Molecular Neurobiology 2022. volume 59, pages 4223–4241

BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23. 12.10.2023 29:56

References Molecular Neurobiology 2022. volume 59, pages 4223–4241 Hum Genet. 1994 Jan;93(1):67-73 Mol Cell Biol. 2012 Jan;32(1):126-38

BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry 12.10.2023 30:00

References The EMBO Journal (2022)41:e109108 Acta Neuropathol. 2007 Sep;114(3):221-9 Acta Neuropathol.2013 Jul; 126(1): 51–57 Brain 2008. Volume 131, Issue 6, Pages 1416–1432 Lovin Spoonful 1968. "She's a Lady" https://youtu.be/xyFdzevDOHg?si=bLl8FZzfE2SffvO4

BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD 10.10.2023 29:23

References Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74LR2JY The EMBO Journal (2022)41:e109108 PLoS ONE 2013. 8(6): e65646. doi:10.1371/journal.pone.0065646 Molecular Neurodegeneration 2022. volume 17,Article number: 73

BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation 10.10.2023 29:46

References Mozart, WA. 1791. Clarinet Concerto in A major , K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5 Small GTPases. 2014; 5: e28579 Acta Neuropathol. 2023; 145(6): 749–772 J Immunol. 2000 May 15;164(10):4991-5

BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic. 08.10.2023 29:58

References Mol Biol Cell. 2001 Sep; 12(9): 2711–2720. Small GTPases. 2014; 5: e28579. Cells. 2021 Jul 20;10(7):1831. J Investig Med. 2023 Feb;71(2):113-123

BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol. 08.10.2023 29:59

References Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC Acta Neuropathol. 2023 Jun;145(6):749-772 Signal Transduction and Targeted Therapy 2022. volume 7, Article number: 175 Cardiovascular Research 2007. 74: 526 – 536 J Investig Med. 2023 Feb;71(2):113-123

BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD. 05.10.2023 30:00

References Neurol Genet. 2018 Jan 18;4(1):e211. J Immunol (2003) 171 (2): 594–599. Acta Neuropathol. 2023; 145(6): 749–772.

BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry. 05.10.2023 30:00

References Neurology. 2020 Jul 7; 95(1): e46–e58 Acta Neuropathol. 2023; 145(6): 749–772.