Authentic Biochemistry

ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry 20.07.2023 28:31 ↓

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579.

ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA. 19.07.2023 30:00 ↓

References Signal Transduction and Targeted Therapy 2021.volume 6, Article number: 412. Nature Immunology. 2022. volume 23, pages 1208–1221.

ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD. 17.07.2023 30:00 ↓

References J Biol Chem. 2021 Jul;297(1):100900 Immunol Rev. 2014 May; 259(1):88–102.

ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry. 15.07.2023 29:59 ↓

Reference Nature Immunology 2022. volume 23, pages 1208–1221.

ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry 11.07.2023 29:16 ↓

References Nature Immunology 2022. volume 23, pages 1208–1221 Signal Transduction and Targeted Therapy 2021. volume 6, Article number: 412.

Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast. 10.07.2023 29:47 ↓

References Guerra lectures archives

Primer on enzyme kinetics in clinical biochemical research. DR. Daniel J. Guerra. 09July2023. Authentic Biochemistry Podcast Productions 09.07.2023 30:00 ↓

Dr Guerra lecture notes

PhotosynthesisV. Photorespiration and synthesis of this holiday arc: fait accompli. DJGPhD.08July23b. Authentic BiochemistryPodcast. 09.07.2023 29:59 ↓

References Guerra's plant biochemistry lectures

Photosynthesis 4. Chlorophyll and carotene biosynthesis and some further detail on the mechanism of the Mn-H20 splitting complex of p680 PSII and diatomic molecular oxygen (O2) evolution.DJGPhD. 7July 08.07.2023 30:00 ↓

References Plant Biochemistry lectures archives :Guerra Phys. Chem. Chem. Phys., 2020,22, 7912-7934 Nature Plants 2017. volume 3, Article number:17041

Photosynthesis 3. Dr Daniel J Guerra. 07July2023 Authentic Biochemistry Podcast productions 06.07.2023 29:53 ↓

Guerra: Plant biochemistry Lectures

Unique Lecture Post holidayIV. Photosynthesis 2. DJGPhD.05July23b Authentic Biochemistry Podcast production. 05.07.2023 30:00 ↓

References Plant Biochemistry Lectures -Guerra

Unique Lecture Series Post holiday. III Higher plant photosynthesis 1. DJGPhD. 05July2023. Authentic Biochemistry Podcast. 05.07.2023 30:00 ↓

References Guerra. Plant Biochemistry lectures

Unique Lecture Series Holiday Time 4th of July2023.Non-arbitrary C-C bond formation chemistry: Aldol and Claisen condensation with Stork enamine synthesis (i.e. Michael reactions) 04.07.2023 29:54 ↓

Reference Organic chemistry : reaction mechanism lectures

Unique Lecture Series . Holiday Time. 4th of July 2023! Hydrocarbons. 01.07.2023 30:00 ↓

Very basic lecture material

ImmunoEpigenetics 89. Final synthesis of statin drug mediated alteration of metabolism in T lymphocytes. DJGPhD.6.30.23. Authentic Biochemistry Podcast. 30.06.2023 29:56 ↓

References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Previous 5 lectures in Authentic Biochemistry and refs. contained therein https://youtu.be/dyy0p90GO2w

ImmunoEpigenetics 88. Statin treatment of early progenitor T cell acute lymphoblastic leukemia could pose biochemical impositions on healthy lymphocyte populations. DJGPhD.29.6.23.Authentic Biochem. 30.06.2023 29:56 ↓

References Oncotarget 2021.12.(13) Cancers (Basel). 2020 Aug 1;12(8):213 Cancer Discov. 2022 Mar 1; 12(3): 856–871

ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture. 28.06.2023 29:58 ↓

References JBC.2002. Volume 277, ISSUE 2, P1128-1138. Cancer Discov. 2022 Mar 1; 12(3): 856–871. Guerra lectures-lipid metabolic regulation Guerra lectures-pharmacodynamics and kinetics

ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem 28.06.2023 28:53 ↓

Reference Cancer Discov. 2022 Mar 1; 12(3): 856–871.

ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23 25.06.2023 28:50 ↓

References Cancer Discov. 2022 Mar 1; 12(3): 856–871. Sci Signal. 2015 Mar 31;8(370):re4

ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD. 24.06.2023 29:43 ↓

References J Exp Med. 2017 Jul 3;214(7):1861-1876 Immunol Rev. 2014 Sep;261(1):62-83 Int J Mol Sci. 2022 Mar; 23(5): 2878. Immunity 2022. Volume 55, Issue 8. :1402-1413.e4

ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast 23.06.2023 30:00 ↓

References Guerra: logical propositions and dialectical syntheses Annual Review of Immunology2021. Volume 39: 279-311

ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD 23.06.2023 29:17 ↓

References Nat Protoc. 2017 Nov;12(11):2342-2354 Annual Review of Immunology 2021. Volume 39. pp 279-311 Immunity 2022. Volume 55, Issue 8. Pages 1402-1413.e4

ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD. 22.06.2023 30:00 ↓

References Immunity 2022. 55, Issue 8. Pages 1402-1413. Methods Mol Biol. 2018;1675:167-181. Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Cell Reports 2015 10, 2043-2054DOI: (10.1016/j.celrep.2015.02.057)

ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23 18.06.2023 30:00 ↓

Reference Authentic Biochemistry Lecture synthesis

ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry 17.06.2023 29:50 ↓

Reference J BiolChem. 2023 Mar; 299(3): 103019.