Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Dr Daniel J. Guerra

Episodes

BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation 21.08.2023 29:55

Reference J Hum Evol. 2022 Oct; 171: 103229.

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23 19.08.2023 30:00

References Immunity 2021. 54, 2273–2287 Front Immunol. 2020. 11: 784

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP. 18.08.2023 29:54

__ [Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670 Oncol Rep. 2023 May;49(5):93

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD 17.08.2023 29:56

References Steroids. 2022 Sep;185:109053 Trends Neurosci. 2015 Jun; 38(6): 364–374 Progress in Molecular Biology and Translational Science Volume 168.Pages 257-275 Histol Histopathol. 2018 Jan; 33(1): 1–10.

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry 16.08.2023 30:00

References Histol Histopathol. 2018 Jan; 33(1): 1–10 J Steroid Biochem Mol Biol. 2022Feb;216:106040 Steroids. 2022 Sep;185:109053

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD. 14.08.2023 30:00

References J Steroid Biochem Mol Biol. 2022. Feb;216:106040. Steroids. 2022 Sep;185:109053

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23 14.08.2023 28:35

References Alzheimer's Research & Therapy 2021. volume13, Article number: 56. Progress in Molecular Biology and Translational Science 2019. Volume 168 #

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD 13.08.2023 29:59

References Genes & Immunity 2021 volume 22, pages 125–140 Arch Endocrinol Metab. 2022 Jan-Feb; 66(1): 77–87 Essays Biochem. 2021 Nov; 65(6): 913–925

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD. 11.08.2023 29:57

Reference Journal of Cognitive Neuroscience (2022)34 (8): 1500–1520

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD 09.08.2023 29:03

References Mol Neurobiol 2020 Jun; Vol. 57 (6), pp. 2654-2670 Brain Res. 2009 Sep 22; 1290: 1–11. JAMA.2003;289(20):2651-2662.

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB. 08.08.2023 29:55

References JAMA.2003;289(20):2651-2662. Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Psychiatry. 2019 Sep 15;86(6):421-432

BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection. 07.08.2023 29:59

References Essays Biochem. 2021 Nov; 65(6): 913–925 Front. Endocrinol. 2022. AUGUST. v.13 .Sec. Molecular and Structural Endocrinology

BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23 05.08.2023 29:59

Reference Essays Biochem. 2021 Nov; 65(6): 913–925

BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23 05.08.2023 30:00

References Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Sex Differ. 2023; 14: 34.

BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry 03.08.2023 30:00

References Biol Sex Differ. 2023; 14: 34 J Cell Sci 2005;118:4605-4612 EBioMedicine. 2015 Dec; 2(12): 1888–1904 PLoS Genet. 2013 Jun; 9(6): e1003556

From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast 31.07.2023 29:31

Reference Some light on the forest floor of wisdom

The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast 30.07.2023 30:00

References Experience et al.

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry 30.07.2023 29:30

References Mol Cancer. 2023 Apr 10;22(1):69 Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415 Semin Immunol. 2010 Dec; 22(6): 311–312

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast. 28.07.2023 30:00

Reference Front Immunol.2022; 13: 890056. previous IE lectures 1-3.

ImmunoEpigenetics 99. Tregs can foster a massive tumor microenvironment inhibition of T-eff cell populations via neo-antigen activation from dying tumor cells leading to cancer progression. DJGPhD 27.07.2023 29:30

Reference Cancers (Basel). 2021. Apr; 13(8): 1850.

ImmunoEpigenetics 98. TCR mediated protection from neonate infection is naturally suppressed. BCG VAX may be a treatment against Type 1 Diabetes by increasing Treg mediated autoimmune suppression. 26.07.2023 29:59

References NPJ Vaccines. 2018; 3: 23. Immunol Cell Biol. 2022 Aug; 100(7): 562–579

ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23 24.07.2023 29:56

References Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234. Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195

ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23 23.07.2023 29:18

References J Immunol. 2014 Aug 15; 193(4): 1531–1537 Immunology lecture notes-Guerra

Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast. 23.07.2023 29:29

Inspirations A hot summer day and what passes as a ponder on the asymmetric.

ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23 20.07.2023 29:59

Reference Immunol Cell Biol. 2022 Aug; 100(7):562–579.