Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1330 episodes

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Author

Dr Daniel J. Guerra

Episodes

BioMedical PortraitVIII.c.13 Leukotriene metabolism and reception is linked to innate like lymphocytes involved in airway inflammation and hyper-responsiveness-associated asthma.DJGPhD.19.1.24.AB. 20.01.2024 29:40

References J Immunol. 2009 Feb 1; 182(3): 1641–1647. Cell Reports 2015 10, 2043-2054DOI Virchows Archiv:European Journal of Pathology. 2020. 09456317, Vol. 476, Issue 2 Poe, EA. 1845. "the Raven" https://youtu.be/wAdQ3CcPHQU?si=2qpStYF2gdUJ4f35 Buddy Morrow and his Orchestra. 1960. "the Black Cat" https://youtu.be/9w_VL7oq-mE?si=XiorgTkvSGzJ4BK0

BioMedical Portrait VIII.c.12. 5-LOX associates with FLAP and PLA2 at the nuclear envelope to trigger and control ILC2 mediation of the allergic asthma AHR pathology. DJGPhD 17.1.24. Authentic Bioch. 18.01.2024 30:00

References Immunology. 2019 Apr; 156(4): 402–412. J Immunol. 2017 Aug 1; 199(3): 1096–1104 Front. Immunol., 06 June 2019 Mol Biol Cell. 2012 Nov 15; 23(22):4456–4464. Virchows Archiv: European Journal of Pathology, 09456317, Feb2020, Vol. 476, Issue 2 Pavana, Gagliarda, Ciaccona, Passacaglia 1535-1615. https://youtu.be/AY533zpCw74?si=224HuGs438aPHrrd

BioMedical Portrait VIII. C.11 Peptidyl leukotrieneR- mediated transcription of PTGS2and LOX15B with IL4/IL13 and IL33 in asthmatic lung airway constrictionin MDM's LM's and ILC2's DJGPhD.16.1.24 17.01.2024 29:35

References Immunol.2017 Aug 1; 199(3): 1096–1104. British J of Pharmacology. 2015. Volume172, Issue17: 4319-4330 Beethoven, L. 1826. String Quartet Op. 135 in F Major (#16) https://youtu.be/1hxpIQ3XhXA?si=65eTt7TlOZYCNsG8

BioMedical Portrait VIII. c.10. The LOX5 and LOX12/15 pathways for 20:4, 20:5 and 22:6produce over 50 unique molecular species of oxylipins and lipoxins with unique biological sequalae.DJGPhD.14.1.24. 15.01.2024 29:40

References Int. J. Mol. Sci. 2022, 23(23), 14883. Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726. British J of Pharmacology. 2015. Volume172, Issue17. 4319-4330 Mozart, WA. 1791. Requiem. D Minor, K. 626 https://music.youtube.com/watch?v=RDegrbjfiWU&si=x-SSYDxEOv5Vc4xE Miller, S. 1977. Wintertime. https://youtu.be/HUv7pXgZ9NA?si=JzaZOWKLkPEMiyKj

BioMedical Portrait VIII. c.9. Initial detail of the LOX vs.COX isoform utilization of essential and other dietary PUFA's in complex leukotriene biosynthesis. DJGPhD.11Jan24.Authentic Biochemistry. 12.01.2024 30:00

References British J of Pharmacology 2015. Volume172, Issue17September Pages 4319-4330 Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726. 1718. Concerto No. 4 in F minor , Op. 8, RV 297, "Winter" ( L'inverno )

BioMedical Portrait vIII. Leukotrienes. c.8 Leukotriene regulated Heterodimer Nuclear Receptor transcription factors organize around complex multi-ligand binding and sojourner molecular modifiers 10.01.2024 28:54

References British J of Pharmacology 2015. Volume172, Issue17 September Pages 4319-4330 Chem Rev. 2011 Oct 12; 111(10): 6321–6340 JBiol Chem. 2020 Jul 17; 295(29): 10045–10061 Mozart, WA. 1768. January. Symphony #7 in D major K.45.composed in Vienna just 10 days before he turned 12 years old. https://youtu.be/ABOle_eSq9c?si=GcA8EvXbpEZP0W0A

BioMedical Portrait VIII.c.7. Differential control over fatty acid oxygenation and PPAR/RXR heterodimer pairing in mammalian uterine cell estrus physiology.DJGPhD.8Jan2024 09.01.2024 30:00

References General and Comparative Endocrinology,2018-06-01, Volume 262, Pages 27-35 Pisendel JG 1735.Violin Concerto in D major, JunP I.5. https://youtu.be/dvwhXXvFiNg?si=YfS2waKLC5WHy0En

EtOH Membrane Intoxication c.3. Epiphantei: ethanol-induced membrane degeneration results in altered porosity/tortuosity dynamics and microglia-failed tissue surveilance/repair in the CNS.DJGPhD. 06.01.2024 30:00

References Brain Imaging Behav. 2011 Sep; 5(3): 189–202 PLoS One. 2019; 14(1): e0210888. Alcohol, 2017-12-01, Volume 65, Pages 51-62 Clapton, E. and Martin Sharp .1967 "Tales of Brave Ulysses" https://youtu.be/I32Wwfv8v1U?si=TfUX6Xldenp_f5M5

EtOH c.2 Mean diffusivity and tortuosity metrics in ethanol induced white matter lesions. 06.01.2024 30:00

References PLoS One. 2019; 14(1): e0210888 Trends Neurosci. 2015 Jun; 38(6): 364–374 Addict Biol. 2006 Sep; 11(3-4): 339–355 Sci Rep. 2022; 12: 19463. Beethoven, L. 1809. Piano Concerto #5 in E-flat major, Op. 73, " Emperor Concerto " https://youtu.be/kiW-QnQzN9Y?si=qT6PgbhB9L5jpzcZ

BioMedical Portrait VIII.c.6 Precursor 20:4 5,8,11,14 derived prostaglandins and leukotriene roles in PPAR and RXR transcription factor expression in mammalian reproductive tissues. DJGPhD. 04JAN24.AB 04.01.2024 30:00

References General and Comparative Endocrinology 2018-06-01, Volume 262, Pages 27-35. Immunohorizons. 2022 Jun 22; 6(6): 366–372. Biochem J. 2009 Dec 14;425(1):265-74. Nature. 2023; 614(7948): 530–538. Winwood,S. 1969 Blind Faith "Had to Cry Today". https://youtu.be/Z4Yo_VbGdMg?si=3whbMcoWNFtfgPwE

Post Holiday EtOH Lectures. Volume One. Dr. Daniel J. Guerra. 01Jan2024. Authentic Biochemistry 02.01.2024 27:56

References Sci Adv. 2020 Jun; 6(26): eaba0154 Brahms , J. 1869 Schicksalslied ∙ hr-Sinfonieorchester. https://youtu.be/yC8CNpFu_7Q?si=ZqE0nuvXjaRJVcMh

BioMedical Portrait VIII.c.5 Leukotrienes. Lipoxygenase isoform mediated control over resident tissue macrophage speciation.Dr Daniel J. Guerra. 01Jan2024. Authentic Biochemistry Podcast 01.01.2024 29:58

References Immunohorizons. 2022 Jun 22; 6(6):366–372. Biochem J. 2009 Dec 14;425(1):265-74 Chem Rev. 2011 Oct 12; 111(10): 6321–6340. Telemann, Georg Philipp. 1699.Trauer-Actus, Cantus Cölln, Junghänel https://youtu.be/0yS7YIcwBq0?si=UaVMZzBtZc27t5Xp

BioMedical Portrait VIII. c.4 A deft-handed apprehension of chirality to facillitate reasoned appreciation of leukotriene molecular heterogeneity.DJGPhD. 30.12.23. Authentic Biochemistry. 31.12.2023 29:32

References Dr Guerra-notes Schubert. F. 1815 (late March-Early April. Stringt Quartet No. 9 in G minor (D.173) https://youtu.be/piIet7QVLGA?si=FcY0VUUXRPPekKs1

BioMedical Portrait VIII.c.3. Leukotriene molecular speciation involves subcellular re-distribution of modifying enzymes and adaptor proteins associating with ER and Nuclear membranes.DJGPhD.28.12.23 29.12.2023 29:59

References Infect Immun. 2021 Aug; 89(8): e00095-21. Eur J Immunol. 1992 Oct;22(10):2705-11 Progress in Lipid Researc 2015. h Volume 57 , January Pages 13-39 Am J Physiol. 1999 Apr;276(4):C988-94. Beethoven, L. 1813, 08 December.: Symphony no. 7 in A major, op. 92. https://youtu.be/T7CjuvE8oFA?si=il248jF2v7njd-Jo

BioMedical Portrait VIII.c.2 Leukotrienes: regio-associated oxygenation patterns of lipoxins and peptido-LTC's distrubute among pro-inflammatory states . DJGPhD. 27.12.23. Authentic Biochemistry 28.12.2023 29:51

References Am J Physiol . 1999 Apr;276(4):C988-94. Acta Derm Venereol 2017; 97: 922–927 Signal Transduction and Targeted Therapy 2021. volume 6 ,Article number: 94 J Adv Res. 2018 May; 11: 33–41. Progress in Lipid Research 2015. Volume 57 , January:13-39

BioMedical Portrait VIII. c.1 Leukotrienes: an Introduction. Dr Daniel J. Guerra. 26.12.23 Authentic Biochemistry Podcast. 27.12.2023 29:58

References J Periodontol, 2007. August 1. 78(8): 1620-6. Annu. Rev. Pharmacol. Toxicol. 2023. 63:407–28 Acta Derm Venereol. 2017; 97: 922–927 Moody Blues 1967.Nov10. Days of Future Passed. https://youtu.be/uZCzH8q1hcY?si=2cWl06wuBC4itE1k

Christmas Eve Special:Research science relies on the means by which it is apprehended thus continuously challenged and improved with the goal of finding truths about nature in perpetuity.DJGPhD 25.12.2023 27:51

References Guerra's epistemology and metaphysics :brief sketch Baroque Christmas Concert with works by Bach, Handel and Mozart Freiburg Baroque Orchestra https://youtu.be/3VupBizhIn4?si=jBOcxwesBtMPv_I1

Dyslipidaemia Coda IV. Antinomies and paralogisms in discerning apoplipoprotein contribution to HTG vs.CAD. DJGPhD.21.12.23.Authentic Biochemistry. 21.12.2023 29:51

References Biomolecules 2021, 11(7), 1016 Journal of Clinical Lipidology Volume 16, Issue 4, July–August Pages 472-482 Schubert. F. 1825. Symphony No. 9 in C major , D 944, https://youtu.be/Ip06DEeY_U8?si=pP8NP22m9XXmpz7z

Dyslipiaemia Coda III. The proposed use of apolipoprotein serum concentration and hyperTAG may require a deeper analysis at the transcriptomic and proteomic levels. DJGPhD.20.12.23 Authentic Biochem. 21.12.2023 30:00

References Biomolecules 2021, 11(7), 1016 Journal of Clinical Lipidology Volume 16, Issue 4, July–August Pages 472-482 Lennon-McCartney 1964. If I Fell https://youtu.be/F_80s6S_7Vw?si=PmlyAATePHfqmzqv Lennon-McCartney. 1963. Misery.https://youtu.be/qhbcN3ew9z0?si=DvePBioaAgZ7_dRW Alexander. A. 1962. Anna. Cover by the Beatles. https://youtu.be/b3zNKWyLfus?si=kEaNqNy_JF_HZNji

DYSLIPIDAEMIA CODA II. Hypertriacylglycerolaemia is linked to mutations in LPL and various apolipoproteins linking CAD to TAG. 18.12.23. DJGPhD.Authentic Biochemistry 18.12.2023 29:49

References Journal of Clinical Lipidology. 2022. Volume 16, Issue 4, July–August. Pages 472-482. Guerra. 2023. -Lecture notes JLR. 2012. Volume 53, Issue 9 , September. Pages 1783-1799 Mozart, WA. 1782 Serenade No12 C.Minor. K388/384a https://youtu.be/xOaP9G-9wi8?si=CE8d9hcuUfbaqa4z

BioMedical Portrait VII. C.7. Lipoprotein biosynthesis and apolipoprotein structure. DJGPhD. 16.12/23. Authentic Biochemistry 16.12.2023 29:59

References Dr Guerra-lecture notes Journal of Clinical Lipidology2022.Volume 16, Issue 4, July–August Pages 472-482

BioMedical Portrait VII.c.6 Lipoprotein Lipase regulation performs a critical role in lipid homeostasis as evidenced by chylomicron clearance resistance in obese dyslipidaemic adolescents and adults. 14.12.2023 30:00

References Nutrients. 2021 Jan 28;13(2):413 Nutrients. 2022 Jun 12;14(12):2438 J Diabetes Investig. 2023 Oct;14(10):1148-1156 Clinica Chimica Acta 2020. Volume 508, September Pages 61-68 Vivaldi. A. 1715. Gloria RV.589 https://youtu.be/XxwtYIKI9dE?si=ksQHEkQf5OlBpHCR

BPVII.c.5 Diminished circ.LPL and adiponectin in obese adolescents correlates with higher dyslipidaemic T2D, MetSynD, and insulin resistance via inflammation-triggering lipoprotein non-clearance. 12.12.2023 30:00

References Nutrients. 2021 Feb; 13(2): 413. Advances in Clinical Chemistry Volume 64 , 2014, Pages 117-177. Front Physiol. 2020; 11: 796. Int J Mol Sci. 2023 Sep; 24(18): 13942. J Diabetes Investig. 2023. Oct;14(10):1148-1156. Nutrients. 2022 Jun 12;14(12):2438 RNA Biol. 2023; 20(1): 737–749. Clinica Chimica Acta Volume 508, Pages 61-68 Kirwan, Danny. 1971. "Sands of Time" Fleetwood Mac...

BioMedical Portrait VII. C.4 Chylomicron associated endothelial luminal LPL differential interaction with ANGTPL isoforms reults in unique TRL disposition. DJGPhD.10Dec23 11.12.2023 29:59

References J Diabetes Investig. 2023Oct;14(10):1148-1156 J Pediatr. 2021 Apr; 231: 200–206.e1. Front Physiol. 2020; 11: 796. ClinicaChimicaActa.2020 Volume 508, September Pages 61-68 Mozart,WA. 1787. Eine kleine nachtmusik K.525 https://youtu.be/nPbxIT9W1AY?si=mgzBQzpvuFzsVNtB

BioMedical Portarit VII. c.3. Introduction to chylomicron apoB48 and the angiopoietin-like LPL inhibitor contributions to circulating TAG. DJGPhD.9DEC23. authentic Biochemistry 09.12.2023 29:56

References Am J Physiol Endocrinol Metab. 2021 Oct 1; 321(4): E493–E508. Clinica Chimica Acta Volume 508, September Pages 61-68 Advances in Clinical Chemistry Volume 64, Pages 117-177 Pancreas. 2017 Aug; 46(7): 874–879 Mozart WA 1775 Violin Concerto in G major, K. 216 https://youtu.be/j7Z6gouAVCc?si=X-3AnGtJoVvf7aF9