Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Author

Dr Daniel J. Guerra

Episodes

BioMedical Portrait V. The neutrohil oxidative burst and the roles of Phox generating superoxide and peptide arginine deiminase in phagocyte defense against pathogens and contrarion disease promotion. 26.10.2023 30:00

References Blood (2004) 103 (11): 3993–3994 Anticancer Agents Med Chem. 2023;23(3):256-265 Med Hypotheses. 2021 Jan:146:110466.

BioMedical Portrait V. Introductory alethic unfolding of neutrophil glycolysis associated hyperinflammatory restraint. 24.10.2023 29:56

References Cell. 2021 Aug 19;184(17):4480-4494.e15 Sci Rep. 2019 Mar 5;9(1):3433 Med Hypotheses. 2021 Jan:146:110466. Hayward, J. 1967. Moody Blues. "Tuesday Afternoon" https://youtu.be/jmMPBQ4kYKk?si=X0UyZJFq2AAnKSvJ

Continuing dialectical event ontology of epistemological requirements for validation of biochemical research. DJGPhD.23.10.23. Authentic Biochemistry Podcast 23.10.2023 29:59

Send an email to authenticbiochemistry@gmail.com with comments.

All reciprocity in not disinterested so phenomena must be in equilibrium. But phenomena at equilibrium are invisible so reciprocity must be uncertain. DJGPhD.22.10.23. Authentic Biochemistry 23.10.2023 29:59

Vide supra.

BioMedical Portrait IV. Postcript DJGPhD. 21 October 2023. Authentic Biochemistry Podcast 22.10.2023 30:00

References Cureus. 2022. 14(9): e29696.doi:10.7759/cureus.29696 NMR Biomed. 2021 Feb;34(2):e4448. NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Nutrients. 2023 May; 15(9): 2029. Mozart, WA. 1791 K 626 Requiem in d minor.

BioMedical Portrait IV. 13b. Magnetic Resonance Imaging as a non-invasive tool in Neurodegenerative Diseases. DJGPhD.19.10.23 Authentic Biochemistry. 19.10.2023 30:00

References Mol Cell Neurosci. 2012 Jan; 49(1): 44–53 NMR in Biomedicine. 2023. e4896. ISSN 0952-3480 Proc Natl Acad Sci U S A. 2020 Mar 10; 117(10): 5092–5094.

BioMedical Portrait IV. CODAIII. c13. Microglial and astrocytic CNS local neuronal environment temporality may apprehend FTD stages in the human CNS.DJGPhD.18.10.23. Authentic Biochemistry Podcast 18.10.2023 30:00

References Brain. 2023 Sep 13:awad309. doi: 10.1093/brain/awad309 J Alzheimers Dis. 2016 Feb 26;52(1):43-50. Haydn, FJ. 1796. MISSA IN TEMPORE BELLI https://youtu.be/8_5tgmAwN-E?si=AYzyMMk47b2IUt0Y Send an email to Dr Guerra! authenticbiochemistry@gmail.com

BioMedica; Portrait IV Coda II.c12. Biochemical Concatenations-the spatiotemporal sequences of molecular-cellular events of FTD's from proteinopathies to signalling and antigen recognition. DJGPhD. 17.10.2023 29:55

References Brain. 2023 Sep 13:awad309 McBroom, Amanda. 1970 "the Rose" httBps://youtu.be/cO59ITNCxzk?si=v-qx_2_mPq3zbCYH

BioMedical Portrait IV c11. FTLD-tau is correlated with microglial and astrocytic inflammation and subsequent neural degeneration. DJGPhD. 16.10.23 Authentic Biochemistry. 17.10.2023 30:00

References Front. Immunol., 19 October 2022 Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309

BioMedical PortraitIV The Frontal Temporal Dementias. Tau and TDP43 proteinopathies as an introduction to the extended pathobiochemical event ontologies. DJGPhD.16.10.23.Authentic Biochemistry Podcast 16.10.2023 30:00

References Schubert, F. 1820. Rosamunde Overture. https://youtu.be/3Pc_LUItWQI?si=ZB3bsrmz3ReiJQdi Brain. 2023 Sep 13:awad309. doi:10.1093/brain/awad309.

BioMedical Portrait IV. TDP43 is involved in numerous pathologies that connect to the major cellular mechanisms governing DNA RRR, RNA metabolism and protein mediated cell fate. DJGPhD.14.10.23 14.10.2023 28:45

Mol Cell Biol. 2012 Jan;32(1):126-38 Mutat Res. 2013 Jul-Sep;753(1):24-40 Molecular Neurobiology 2022. volume 59, pages 4223–4241

BioMedical Portrait IV c8. Proteolytic processing of cytosolic RNA-bp ,TDP43, associates with CNS neuropathologies while native nuclear translocation is linked to exon shuffling. DJGPhD.12Oct23. 12.10.2023 29:56

References Molecular Neurobiology 2022. volume 59, pages 4223–4241 Hum Genet. 1994 Jan;93(1):67-73 Mol Cell Biol. 2012 Jan;32(1):126-38

BioMedical Portrait IV c7.Progranulin associated frontotemporal lobar degeneration and AD, PD, and LBD, share a TDP-43 proteinopathy linked to mRNA translation. DJGPhD.11OCT23. Authentic Biochemistry 12.10.2023 30:00

References The EMBO Journal (2022)41:e109108 Acta Neuropathol. 2007 Sep;114(3):221-9 Acta Neuropathol.2013 Jul; 126(1): 51–57 Brain 2008. Volume 131, Issue 6, Pages 1416–1432 Lovin Spoonful 1968. "She's a Lady" https://youtu.be/xyFdzevDOHg?si=bLl8FZzfE2SffvO4

BioMedical Portrait IV. c6. Proteinopathies in neurodegeneration may be the result of insufficient temporal control over microglial phagocytic and pro-inflammatory molecular event ontologies.DJGPhD 10.10.2023 29:23

References Brooker, G; Fisher, M and Reid, K. Procol Harum 1967. A Whiter Shade of Pale. https://music.youtube.com/watch?v=z0vCwGUZe1I&si=4iY2IY06x74LR2JY The EMBO Journal (2022)41:e109108 PLoS ONE 2013. 8(6): e65646. doi:10.1371/journal.pone.0065646 Molecular Neurodegeneration 2022. volume 17,Article number: 73

BioMedical Portrait IV.c5. Microglial removal of lipoprotein and proteinopathic molecular events must include lysosomal degradation and antigen presentation while supporting signaling and inflammation 10.10.2023 29:46

References Mozart, WA. 1791. Clarinet Concerto in A major , K. 622 https://youtu.be/YT_63UntRJE?si=bXBDcxTxsY1PxJa5 Small GTPases. 2014; 5: e28579 Acta Neuropathol. 2023; 145(6): 749–772 J Immunol. 2000 May 15;164(10):4991-5

BioMedical PortraitIVc4. Microglial Rho GTPases equipped with GGylation, palmitoylation and/or phosphorylation obtain a spectrum of biochemical functions in neuropathologies.DJGPhD.8Oct23b. Authentic. 08.10.2023 29:58

References Mol Biol Cell. 2001 Sep; 12(9): 2711–2720. Small GTPases. 2014; 5: e28579. Cells. 2021 Jul 20;10(7):1831. J Investig Med. 2023 Feb;71(2):113-123

BioMedical Portrait IV. c3. Two down-regulated microglial polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy distinct LDL binding proteins typically cargo oxy cholesterol. 08.10.2023 29:59

References Sinatra, Frank. timeless. My Way. https://youtu.be/qQzdAsjWGPg?si=TcpVOHDikKyyQdmC Acta Neuropathol. 2023 Jun;145(6):749-772 Signal Transduction and Targeted Therapy 2022. volume 7, Article number: 175 Cardiovascular Research 2007. 74: 526 – 536 J Investig Med. 2023 Feb;71(2):113-123

BioMedical PortraitIV.NHD patient fibroblasts used to generate iPSC's differentiated into Induced microglia like cells (iMGLs) pathophenocopied TREM2 mutations and lysosomal malfunctions.DJGPhD. 05.10.2023 30:00

References Neurol Genet. 2018 Jan 18;4(1):e211. J Immunol (2003) 171 (2): 594–599. Acta Neuropathol. 2023; 145(6): 749–772.

BioMedical Portrait IV. HLA disease including neuropatholgies. The Nasu-Hakola, a.k.a. polycystic lipomembranous osteodysplasia associated TREM2 disease. DJGPhD.04Oct2023.Authentic Biochemistry. 05.10.2023 30:00

References Neurology. 2020 Jul 7; 95(1): e46–e58 Acta Neuropathol. 2023; 145(6): 749–772.

BioMedical PortraitIIIC13c. Leucocyte and lymphocyte mediated SASP involve a corruption in robust novel immune responses while enhancing chronic autoimmune inflammation in the obese and elderly.DJGPhD 02.10.2023 29:49

References Curr Opin Pharmacol. 2021 Apr; 57: 107–116

BioMedical PortraitIII. c13b.Immune cell metabolic dialectical usurpation of architechtonic control over inflammation and cell fate obtained from senescence and obesity.-linked dyslipidaemia.DJGPhD. 01.10.2023 29:03

References Pisendel Johann G. 1735. Violin Concerto in D major Jun P I.7 https://youtu.be/dvwhXXvFiNg?si=BUb-f5rBncgADinx Curr Opin Pharmacol. 2021 Apr; 57: 107–116

BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease 30.09.2023 29:05

References Telemann Georg P. 1765. Overture D Major, TWV 55:D18 | Tafelmusik https://youtu.be/8r-IFLtN9x4?si=T2hp65oGT--dTivY Leukemia 2020 volume 34, pages 75–86 Nat Cell Biol. 2019 Mar; 21(3): 397–407

BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD. 28.09.2023 29:59

References Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX Leukemia 2020. volume 34, pages 75–86 CELL 2006. Volume 126, Issue 3, Pages 503-514 Nat Cell Biol. 2019 Mar; 21(3): 397–407. Curr Opin Pharmacol. 2021 Apr; 57: 107–116.

BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD. 26.09.2023 29:19

References Saint-Saens. C. 1886. Symphony 3 (avec orgue) OP.78 J Clin Invest. 2011 Dec 1; 121(12):4903–4915 Cell Metab. 2022 Dec 6; 34(12): 2036–2046.e8.

BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast 26.09.2023 29:17

References Cell. 2020 Jul 23; 182(2):404–416.e14. Curr Genet. 2021 Feb; 67(1): 19–26. RNA Biol. 2023; 20(1): 737–749. published online 13sept23