Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Dr Daniel J. Guerra

Episodes

BioMedical PortraitVI.c.13. Senescense and the aging of cells within systems apprehends the event ontologies of the stress phenomena-immune surveillance axis.DJGPhD.29.11.23. Authentic Biochemistry. 30.11.2023 30:00

References Annual Review of Pathological Mechanisms of Disease 2010. 5:99-118. Immun Ageing. 2020; 17: 16 Williams, Hank.1949. ISLICC. https://youtu.be/4WXYjm74WFI?si=mhYowh4ClIOKmgVX

BioMedical Portrait VI. c.12. Obesity and viral infection-associated NK malfunction may lead to NASH and subsequent HCC. DJGPhD.28.11.23. Authentic Biochemistry 29.11.2023 30:00

References Ann. Review of Pathological Mechanisms of Disease2010.5:99-118. Nature 2013 Jul 4;499(7456):97-101. Front Immunol. 2018; 9: 476 Cells. 2021 Jun; 10(6): 1332 Nat Rev Gastroenterol Hepatol (2023). https://doi.org/10.1038/s41575-023-00846-4

BioMedical Portrait VI. c.11 NK cell involvement in HepatoCellular Carcinoma. DJGPhD. 26.11.23. Authentic Biochemistry 27.11.2023 30:00

References Front Immunol. 2018; 9: 476 Nature Reviews Gastroenterology & Hepatology 2023. 20 : 662–678 (2023) Cells. 2021 Jun; 10(6): 1332. Traffic, (Traditional. arr. S Winwood )1970. "John Barleycorn Must Die" https://youtu.be/icyPFsIcAV0?si=XSVxsiojZBrwGPx6

"The Universe by Negation" DJGPhD.23.11.23 24.11.2023 28:26

References Dr Guerra's Metaphysics notes Schubert, F. 1828. Quintet in C. Major D.956 https://youtu.be/Dc3iX7x73JY?si=j4jlU4ra_488pAuE

BioMedical Portrait VI.c.10.Alterations in the cytotoxic immune response can be dissociated from inflammation via intermediary metabolic mutation.DJGPhD.22.11.23. Authentic Biochemistry Pootdcast. 23.11.2023 30:00

References Front Immunol. 2023; 14: 1151166. Dr Guerra: Biochemistry lecture archives Telemann, G.P. 1725.Viola Concerto in G major https://youtu.be/yMpzPMkrALM?si=lpyDYITx63jTc6-K

BioMedical PortraitVI.c.9 HLH mutations obtain complex NKvs.CD8+ T cell alterations in cytototoxicity and proliferation.DJGPhD.21.11.23 Authentic Biochemistry. 22.11.2023 29:48

References Immunobiology. 2019 Jan; 224(1): 94–101 Front. Immunol., 14 June 2023 Cell. 2003 Nov 14;115(4):461-73 VonBingen. H. Born 1098AD https://youtu.be/yyAQc0kPZpU?si=y26mnCOmFpRis63_

BioMedical Portrait VI.c.8.The cytotoxicity of the NK cell Is a function of its bioenergetics. Glycolysis/OXPHOS vs. FAO/OXPHOS during activation/proliferation 21.11.2023 29:51

References Front Immunol. 2023; 14: 1151166. Inflammation Research :official journal of the European Histamine Research Society 2018.1420-908X, Vol. 67, Issue 10. J Cell Sci. 2011 Dec 15; 124(24): 4147–4159. Hunter, R. and J. Garcia 1970. "Sugaree" https://music.youtube.com/watch?v=sxF9UJ-Rm0E&si=S4F0LvlFvUsTE1OO

BioMedical PortraitVI.C.7 IEI/IEM pathobiochemistry involves bioenergetics, transcriptional , translational, and post-translational modification sequalae.DJGPhD.19.11.23 Authentic Biochemistry. 19.11.2023 30:00

References Front Immunol. 2022; 13: 950536. Inflamm Res. 2018 Oct;67(10):813-828 Mol Biol Rep. 2023; 50(8): 6963–6974. Front Immunol. 2023; 14: 1151166 Dr Guerra: Graduate biochemistry lecture archive Schubert. F . 1827.December. Impromptu #3 in G flat major performed by Khatia Buniatishvili https://youtu.be/LUp2u9wI1fY?si=hhiUmiyXyQ78Qtaw and "Questions" Manfred Mann 1976. https://youtu...

BioMedical Portrait VI c.6.Hemophagocytic lymphohistiocytosis ACAD9/Rab27A/+/- FBase1 mutations linked to NK and CTL immunodeficiences.DJGPhD. 16/11/23. Authentic Biochemistry. 17.11.2023 29:56

References Front Immunol. 2023; 14: 1151166. Int J Mol Sci. 2019 Jan; 20(2): 443.

BioMed Portrait VIc.5. NK cell Inborn Error Of Immunity links to failed fatty acyl CoA dehydrogenase-obtained immunodeficiency.DJGPhD. 15.11.23. Authentic Biochemistry 16.11.2023 30:00

References Front Immunol. 2023; 14: 1151166

BioMedical Portrait VI.c4. Tumor and DC antigen VAX directed melanoma therapy reveals CD8+CTL and NK cell surface population dynamics.DJGPhG.14.11.23. Authentic Biochemistry. 15.11.2023 30:00

References Cancers 2020, 12 (4),952 JBC. 2018. 293: 2422-2437. J Immunother Cancer. 2021 Nov;9(11):e003675 Front Oncol. 2023 May 18:13:1145667 Front. Immunol.2019. Sec. Cancer Immunity and Immunotherapy Volume 10 Int. J. Mol. Sci. 2019, 20(3), 646 Front Immunol. 2019; 10: 14 Vivaldi, A. 1716. RV589 Gloria https://youtu.be/2eWjQOdYzMQ?si=dpZaNZilqPXi6fJU

BioMedical PortraitVIc.3. NK cell phenotypic variation is tighly regulated to facillitate unique immune sequalae including tumor ablation, pathogen elimination and autoimmunity.13.11.23.DJGPhD 14.11.2023 30:00

References Immunity. 2018 Oct 16;49(4):695-708 Front Immunol. 2019; 10: 14 Front. Immunol., 24 July 2017 Vol 8. Sec. T Cell Biology

BioMedical ortrait VI. Development of a dendritic cell antigen presenting melanoma kinase derived vax targeting NK cells to ablate malignancy.DJGPhD.11NOV23 12.11.2023 30:00

References Front Immunol. 2019; 10: 14 Cancer Immunol Immunother. 2016 Apr;65(4):441-52 Anal Cell Pathol (Amst).2018; 2018: 787.1814. Molecular Cancer 2020. volume 19, Article number: 39 Cohan, G. 1917. "Over There" https://youtu.be/BYV044H5muI?si=LdANMG6dtXeC14tj

BioMedical Potrait VI. Natural Killer Cells: opening remarks. DJGPhD.9NOV23. Authentic Biochemistry 09.11.2023 29:42

References Anal Cell Pathol (Amst).2018; 2018: 787.1814 Zeno (the Eleatic) 5thCentury B.C. Magna Graecia, Italian Penn. Student of Parmenides Guerra-basic immunology lectures Schubert,F. 1826. String Quartet No. 15 in G major , D. 887. https://youtu.be/xW8PI2Xa8eA?si=smnLmSKamUP34qon

BioMedical Portrait V. Coda c.13 Small molecule pyrazolo-oxazepine derivitive mediated PFK-1 activation depletes NADPH dependent neutrophil oxidative burst. DJGPhD.07NOV23. Authentic Biochemistry 08.11.2023 30:00

References Cell 2021. 184, 1–15 ⁠J Zhejiang Univ Sci B.⁠ 2022 Jul 15; 23(7): 607–612.

BioMedical Portrait V.c.12. Is there a compositional-sequential event ontology linking "moonlighting"c-Fos with NOX2 PX domain PIP3 binding?DJGPhD. 6NOV23 06.11.2023 30:00

References Nature Communications 2019. volume 10, Article number: 1528 Adv Exp Med Biol. 2019:1111:1-17. doi10.1007/5584_2018_185. Nature Immunology volume 20, pages559–570 (2019) Biochem J. 2001 Dec 15; 360(Pt 3): 513–530. PNAS 1993. 90: 10952-10956

BioMedical Portrait V.c.11 The Phosphoglycerolipid metabolome that orchestrates membrane topology and surface chemistry that supports necessary protein association for neutrophil immunoresponses. 05.11.2023 30:00

References Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids2014.Volume 1841, Issue 9, Pages 1241-1246 Guerra-graduate lipid lectures

BioMedical Portrait V.c.10. Phosphphatidyl inositols and phagosmal genesis in activated neutrophils upon pathogen infection. 05.11.2023 29:54

References J Adv Res. 2018 May; 11: 33–41. Immunol Rev. 2023. Volume314, Issue1 . Special Issue: Neutrophils and Friends .March 2023. Pages 158-180. Biochim Biophys Acta Biomembr.. 2023 Oct;1865(7):184180 Front Cell Dev Biol. 2022; 10: 945749. Tchaikovsky, PI., 1878. Violin Concerto in D major, Opus 35 ( TH 59 ; ČW 54). https://youtu.be/2ckqOukGKK8?si=jl9TYFA2pgvtI8um

BioMedical PortraitV.c9. Both glycolytic and OPP regulation combine complex allosteric and amphibolic sequalae that may converge on an immune- hyperinflammatory state. DJGPhD.2NOV23. 02.11.2023 29:42

References Guerra 2023-graduate biochemistry lecture canon and marginalia Mol Oral Microbiol. 2019 Apr; 34(2): 27–38. Front Cell Dev Biol. 2022; 10: 945749. Mozart, WA. 1784. Piano Concerto No. 17 in G major, KV. 453 https://youtu.be/iYNbMclI5Ls?si=_P9oK14c_wb98VXG

BioMedical Portrait V.c8. NOX2 subunitorganization, oxygen availability and phase I discussion of glycolytic allosteric control.DJGPhD.01Nov23 01.11.2023 30:00

References FASEB 2017. Volume 31, Issue2 Pages 663-673 Guerra,DJ. Graduate Biochemistry Lectures Albioni , Thomaseo. 1708. Sonate da chiesa ("op. 4") (for violin and basso continuo), https://youtu.be/IMmjjcfG2c4?si=C4VG-rPWL_Fv7-Xe

BioMedical Portrait V C.5 Periodontitis-linked CVD. DJGPhD. 30.10.31 01.11.2023 30:00

References Eur J Microbiol Immunol (Bp). 2011 Mar;1(1): 41–58 J Periodontal Res. 2018 Jun; 53(3):403–413. DJGPhD lecture notes

BioMedical Portrait V. c7. NETs and the combined activities of elastase,NOX2,MPO and IP3 PTEN phosphatase potentiate inflammation-linked pathologies of lung and pancreas. DJGPhD.31.10.23 and 01.11.2023 29:59

References J Zhejiang Univ Sci B. 2022 Jul 15; 23(7): 607–612 Biomaterials. 2020 Apr; 238: 119836. Int J Nanomedicine . 2023;18:5265-5287 Child Ballad 100. 1775. Pentangle. 1972.Willie O' Winsbury https://youtu.be/nwqP_yoszCE?si=C0NH51euOOTlPYn9

BioMedical Portrait V C.6 P. gingivalis Two Component System assembly and activation mediate infection court involvement in subsequent host vector pathology.DJGPhD. 30.10.23b. 30.10.2023 30:00

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2):S135–S139. J Oral Microbiol. 2017; 9(1): 1400858

BioMedical Portrait Vc4 Two component signal system pathogenic bacterial responses to host immunity and the gigipain cysteine protease opposing serum secretory IgA mediated phagocyte activation.DJGPhD 29.10.2023 30:00

References J Pharm Bioallied Sci. 2019 May; 11(Suppl 2): S135–S139. J Oral Microbiol. 2017; 9(1): 1400858. J Dent Res. 2020 Jun;99(6):644-649. Mozart WA 1782. D major, K. 385. Symphony 35 (Haffner)

BioMedical Portrait V.c3. The categorical analysis of Neutrophil involvement in multiple pathophysiologies requires cellular signaling to derivatize pleiotropic disease ontologies. DJGPhD.26.10.23 27.10.2023 29:50

References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Gut Microbes. 2022; 14(1): 2073785. Adv Exp Med Biol. 2020:1263:13-23 Bredon, Anne. 1950. Led Zepplin. 1969. https://youtu.be/dZitPJMh60A?si=MnEpM-iemNFWEKE7