Dr Daniel J. Guerra

Authentic Biochemistry

Science EN ↓ 1250 episodes

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Author

Dr Daniel J. Guerra

Episodes

ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means 12.05.2023 30:00

References Free Radical Biology and Medicine 2014. Volume 71, June. Pages 1-15 J Mol Endocrinol. 2020 Nov; 65(4): R77–R90. REDOX and Cholesterol metabolism lectures-Dr Guerra

ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites 10.05.2023 29:19

References Cancers (Basel). 2019 May; 11(5): 678. Oncogene.2017 Mar 23; 36(12): 1607–1618 Dr Guerra's annotated lecture notes from graduate biochemistry course(s)

ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD 10.05.2023 29:50

References Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9 Cancer Drug Resist 2020;3:762-74. Oncogene.2017 Mar 23; 36(12): 1607–1618 Front Immunol. 2020; 11: 1782.

ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability. 09.05.2023 29:59

References Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives Epigenetics. 2019; 14(12): 1183–1193. Drug Discov Today. 2017 Jan; 22(1): 186–193.

Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast 07.05.2023 29:38

References Int J Mol Sci. 2020 Jun; 21(11): 4098.

ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23 06.05.2023 29:47

References Int J Mol Sci. 2020 Jun; 21(11): 4098. Authentic Biochemistry lectures :ImmunoEpigenetics 56-58

ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem. 28.04.2023 29:53

References BMC Medical Genomics. 2015. volume 8, Article number 45. Journal for ImmunoTherapy of Cancer 2022;10:e003826.

ImmunoEpigenetics 57. Plasmacytoid dendritic cell neoplasias and the CAR-T cell tumor microenvironment exposure altering epigenetic TF regulation leading to diverse differentiation. DJGPhD.20.4.23 21.04.2023 30:00

References Current Oncology Reports. 2020. 1534-6269, May 15, Vol. 22, Issue 6. Cell. 2021 Dec 9; 184(25):6081–6100.e26.

ImmunoEpigenetics 56. Dendritic cell immunobiochemistry introductions. DJGPhD. Authentic Biochemistry 15.4.23 15.04.2023 28:37

References Autoimmunity. 2012 Aug;45(5):333-47 Clinical and Experimental Rheumatology 2019: One year in review 2019: systemic lupus erythematosus Trends in Immunology, 2021-01-01, Volume 42, Issue 1, Pages 59-75 Annu. Rev. Immunol. 2000. 18:767–811

ImmunoEpigenetics55. ILC and Treg differentiation is mediated by acetylation and methylation epigenegtic authorship at discrete TF binding site domains.DJGPhD.14.4.23. Authentic Biochemistry 14.04.2023 28:54

References Cell Reports 2015 10, 2043-2054DOI ID2_HUMAN,Q02363 Experimental & Molecular Medicine 2019. volume 51, Article number: 80.

Immunoepigenetics 54. Macrophages, T lymphocytes and neutrophils each comply with epigenetic alterations to mediate the inflammatory response. DJGPhD.12April.2023.Authentic Biochemistry 13.04.2023 29:56

References Guerra's notes

ImmunoEpigenetics 53.The metaphysics of biochemical control within epigenetic alteration of gene expression as obtained in macrophage mediated immune activation. DJGPhD.7April23'Authentic Biochem 07.04.2023 29:43

References Dr Guerra's lecture notes-Immunology DJGPhD writings on Middle Platonist Metaphysics in Biochemistry: unpublished Curr Opin Biotechnol. 2020 Jun; 63: 111–117

ImmunoEpigenetics 52. Integration of intermediary metabolism with epigenetic modification of immune cell activation and proliferation.DJGPhD. 5April23. Authentic Biochemistry Podcast. 05.04.2023 30:00

References Curr Opin Biotechnol. 2020 Jun; 63: 111–117 Epigenomics. 2019. VOL. 11, NO. 68 May Front. Genet., 23 October 2018 Sec. Epigenomics and Epigenetics Volume 9.

ImmunoEpigenetics 51. The Glutamine contribution to tumor bioenergetics and lipogenesis and the role of storage TAG in macrophage pro-inflammation. DJGPhD. 29.3.23 30.03.2023 27:44

References Nature Communications 2020.volume 11, Article number: 4107. Nutrire 2016. volume 41, Article number: 14

ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD 25.03.2023 30:00

References Cell 2012 148DOI: (10.1016/j.cell.2012.01.031) Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: 71-79. Molecular Cancer. 2020. volume 19, Article number: 39.

ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD 23.03.2023 29:59

References Dr Guerra's lectures and spontaneous expectorations. Molecular Cancer 2020. volume 19, Article number: 39

ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23 21.03.2023 30:00

References Methods Enzymol. 2009; 457: 425–450 Endocrinology , Volume 155, Issue 5, 1 May 2014, Pages 1653–1666 Am J Physiol Endocrinol Metab. 2008 Dec; 295(6): E1287–E1297

Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD 18.03.2023 30:00

References Dr Guerra's lectures AJP Endocrinology and Metabolism. 2008. 295(6):E1287-97 Biochem Biophys Res Commun.1996 May 15;222(2):287-91 Carcinogenesis.2020 Jun; 41(4): 405–416 Oncogenesis 2017. volume 6, page e329.

ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23 16.03.2023 29:22

References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association. 12.03.2023 29:48

References Carcinogenesis. 2020 Jun; 41(4): 405–416 Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39

ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry. 09.03.2023 29:32

References Antioxidants (Basel). 2023 Feb; 12(2): 274 J Lipid Res. 2016 May; 57(5): 868–881. J Biol Chem. 2007 Jan 12;282(2):1384-96. J. Am. Chem. Soc. 2014, 136, 36, 12624–12630

ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe 08.03.2023 30:00

References Int J Hematol 2022. 116, 828–836 Cancer Immunol Res (2022) 10 (1): 87–107 Front Immunol. 2022; 13: 881191 Nature Reviews Immunology 2018. volume 18, pages 617–634.

ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23. 06.03.2023 28:13

References Biochem J 2012 444(1):105-114 Epigenetics. 2015 May; 10(5): 418–430. Nature Reviews Immunology volume 2018. 18, pages 617–634 

ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast 05.03.2023 29:52

References Genes & Diseases Available online 26 December 2022 Int J Mol Sci. 2021 May; 22(10): 5317 Haematologia 2016. Vol. 101 No. 6  June. Blood (2005) 106 (1): 274–286 Nature Reviews Immunology 2018. volume 18, pages 617–634.

ImmunoEpigenetics XXXX. Transcription factor complex permutaions combine with histone acetylomic and methylomic covalent mofications in T -ALL disease. DJGPhD. 04 March 2023. Authentic Biochemistry. 04.03.2023 29:55

References Nature Reviews Immunology volume 18, pages 617–634 (2018) Genes (Basel). 2021 Aug; 12(8): 1118.