Authentic Biochemistry

Biomedical Portrait II. C.7. Serum sphingolipid molecular speciation in women differs from men but association with tissue endomembranous lipid components fail to be addressed.DJGPhD. 31.8.23 31.08.2023 29:57 ↓

References Aging (Albany NY). 2019 Jan 15; 11(1):73–88.

BioMedical Portrait II. Metabolic and Bioenergetic distinction between men and women includes lipid deposition and utilization mechanisms.DJGPhD.30.8.23.Authentic Biochemistry Podcast. 30.08.2023 29:50 ↓

References Front. Endocrinol.2015 Sec. Clinical Diabetes Obes Sci Pract. 2017 Mar; 3(1): 106–114.

BioMedical Portrait II, c.5. Muscle fibre sexual dimorphism obtains networks of genetic, epigenetic, and biochemical events.DJGPhD.29.8.23 Authentic Biochemistry Podcast 29.08.2023 29:54 ↓

Reference BMC Genomics. 2022; 23: 519

Biomedical PortraitII.C.4 THe sexual dimorphism of bioenergetics: introduction to carbon utilization. Video lecture link 28.08.2023 1:37 ↓

https://youtu.be/llYhGi1XSvU

BioMedical Portrait II. Chapter 3. Mitochondrial gene expression, lipid metabolism and cell fate are at least partiatially mediated by Fragile X protein competency. DJGPhD.24.8.23 24.08.2023 30:00 ↓

References Scientific Reports 2015.volume 5,Article number: 15292 Dev Cell. 2023 Apr 10;58(7):597-615.e10

BioMedical Portrait II. The Fragile X Syndrome. Discovery and subsequent association with the FMR1 gene. Premature Ovary Failure I vs. heritable intellectual disabilities DJGPhD.22.8.23 23.08.2023 30:00 ↓

References Genes & Immunity 2021. volume 22, pages 125–140. Prz Menopauzalny. 2017 Jun; 16(2):51–56. J Neuroinflammation. 2016 May16;13(1):109. Am J Physiol Cell Physiol 2022. 322: C125–C135 Adv Human Genetics 1983.13:83 Ann NY Acad Sci . 1986. 477:129 Neurol Neurosurg Psychiatry.1943. 6:154

BioMedical Portrait II.Diseases of Bioenergetics:Male vs. Female Variation 21.08.2023 29:55 ↓

Reference J Hum Evol. 2022 Oct; 171: 103229.

BioMedical Portrait I. 13b. 25 hydroxy cholesterol controling SREBP is linked toinflammation and the regulation of potentiating estrogen mediation over AD in post menapausal women.DJGPHD.18.8.23 19.08.2023 30:00 ↓

References Immunity 2021. 54, 2273–2287 Front Immunol. 2020. 11: 784

Biomedical Portrait I, 13. Receptor boud 17Beta-estradiol may overturn the the failure to synthesize cholesterol in CNS caveolae thus blocking release of Beta-secretase to generate A-beta from APP. 18.08.2023 29:54 ↓

__ [Mol Neurobiol] 2020 Jun; Vol. 57 (6), pp. 2654-2670 Oncol Rep. 2023 May;49(5):93

BioMedical Portraits I. Chapter 12. Unique lipoprotein lipase mediated lipid alteration of endothelial cell function in the mammalian CNS may traffick in oxysterol binding protein linked PM-female AD 17.08.2023 29:56 ↓

References Steroids. 2022 Sep;185:109053 Trends Neurosci. 2015 Jun; 38(6): 364–374 Progress in Molecular Biology and Translational Science Volume 168.Pages 257-275 Histol Histopathol. 2018 Jan; 33(1): 1–10.

BioMedical Portraits I. [11]. Phospholipid and lipoprotein lipase activity may link to oxy-cholesterol/PL transport mechanisms to generate post-menopausal AD. DJGPhD.16.8.23. Authentic Biochemistry 16.08.2023 30:00 ↓

References Histol Histopathol. 2018 Jan; 33(1): 1–10 J Steroid Biochem Mol Biol. 2022Feb;216:106040 Steroids. 2022 Sep;185:109053

BioMedical PortraitI-10. Sterol binding protein and oxysterols regulate membrane fusion and trafficking obtaining a complex landscape for post menopausal estrogen assoc. neurodegeneration.DJGPhD. 14.08.2023 30:00 ↓

References J Steroid Biochem Mol Biol. 2022. Feb;216:106040. Steroids. 2022 Sep;185:109053

BioMedical PortraitsI.9. The 27-hydroxychol association with estrogen receptors and LXR provide contrarion associations with female AD and immune-controlled bacterial pathophysiology.DJGPhD.14.8.23 14.08.2023 28:35 ↓

References Alzheimer's Research & Therapy 2021. volume13, Article number: 56. Progress in Molecular Biology and Translational Science 2019. Volume 168 #

BioMedical Portrait I. Chapter 8. Female AD progression post-menopausal severity is a complex pathobiochemical event that may involve cholesterol and steroid metabolism in the CNS and periphery.DJGPhD 13.08.2023 29:59 ↓

References Genes & Immunity 2021 volume 22, pages 125–140 Arch Endocrinol Metab. 2022 Jan-Feb; 66(1): 77–87 Essays Biochem. 2021 Nov; 65(6): 913–925

BioMedical Portraits I. Chapter 7. Hormone replacement and the general distinctions of cholesterol homeostasis, metabolic zonation, hydroxysterols and estrogen receptor heterogeneity in female AD. 11.08.2023 29:57 ↓

Reference Journal of Cognitive Neuroscience (2022)34 (8): 1500–1520

BioMedical Portraits I. Chapter 6. Complications of female cerebrovascular trauma and obesity-linked Type2 Diabetes in post-menopausal estrogen therapeutics for prophylactic treatment of subsequent AD 09.08.2023 29:03 ↓

References Mol Neurobiol 2020 Jun; Vol. 57 (6), pp. 2654-2670 Brain Res. 2009 Sep 22; 1290: 1–11. JAMA.2003;289(20):2651-2662.

Biomedical Portraits I. Part 5. 17-beta estradiol monotherapy in post-menopausal women has no irrefutable therapeutic benefit for treating cognitive decline in early AD dementia.DJGPhD.8AUG23.AB. 08.08.2023 29:55 ↓

References JAMA.2003;289(20):2651-2662. Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Psychiatry. 2019 Sep 15;86(6):421-432

BioMedical Portraits I. Part 4 Loss of female gonadal E2 production plus CNS E2 Receptor expression post-menopause involves irreversible alterations in metabolism:implications for neuroprotection. 07.08.2023 29:59 ↓

References Essays Biochem. 2021 Nov; 65(6): 913–925 Front. Endocrinol. 2022. AUGUST. v.13 .Sec. Molecular and Structural Endocrinology

BioMedical Portraits I. part 3 Estrogen receptor heterogeneity in signaling and transcription and the distinctions between model-murine and human reproductive and CNS biochemistry.DJGPhD 05AUG23 05.08.2023 29:59 ↓

Reference Essays Biochem. 2021 Nov; 65(6): 913–925

BioMedical Portraits I. Part 2.Murine model Alzheimer's Disease is poorly linked to menopuase or Vascular contributions to Cognitive Impairment & Dementia (VCID).DJGPhD 05AUG23 05.08.2023 30:00 ↓

References Essays Biochem. 2021 Nov; 65(6): 913–925 Biol Sex Differ. 2023; 14: 34.

BioMedical Portraits I. Alzheimers Disease in Ageing Females is linked to CNS-sphingomyelinase mediated ketogenesis and VCID.Lecture 1. DJGPhD.3AUG23.Authentic Biochemistry 03.08.2023 30:00 ↓

References Biol Sex Differ. 2023; 14: 34 J Cell Sci 2005;118:4605-4612 EBioMedicine. 2015 Dec; 2(12): 1888–1904 PLoS Genet. 2013 Jun; 9(6): e1003556

From Intellections' pathway into the forest of metaphysics.II DJGPhD.30.July 2023b. Authentic Biochemistry Podcast 31.07.2023 29:31 ↓

Reference Some light on the forest floor of wisdom

The Road to Intellection I. DJGPhD. 30.7.23. Authentic Biochemistry Podcast 30.07.2023 30:00 ↓

References Experience et al.

ImmunoEpigenetics 100B. Fine. The apodictic recombination-dependent TCR and Ig receptor system is mediated by epigentic modifications.DJGPhD.29.7.23. Authentic Biochemistry 30.07.2023 29:30 ↓

References Mol Cancer. 2023 Apr 10;22(1):69 Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415 Semin Immunol. 2010 Dec; 22(6): 311–312

ImmunoEpigenetics100A. The Tcell repose and ILC differentiation via E vs ID chromatin remodeling antagonism. DJGPhD.28.7.23. Authentic Biochemistry Podcast. 28.07.2023 30:00 ↓

Reference Front Immunol.2022; 13: 890056. previous IE lectures 1-3.