AoPcasts: Series - Bringing you the latest in medical research

Professor Paul Klenerman talks with Professor Christopher Buckley about his recent papers. Professor Paul Klenerman Sidney Truelove Professorship of Gastroenterology, Nuffield Department of Medicine; Fellow of Green Templeton College, University of Oxford Professor Christopher Buckley Director of Clinical Research, Kennedy Institute of Rheumatology, University of Oxford The opinions of our host an...

Reflecting on a distinguished and wide-ranging career as a clinician scientist, Professor Sir Mark Caulfield shares candid insights into the logistical, political and administrative challenges he has encountered along the way. From his early work in hypertension research to his leadership of the landmark 100,000 Genomes Project, he distils the key lessons learned and the practical toolkit needed t...

Fibromyalgia remains a challenging and often misunderstood condition, traditionally viewed through the lens of central sensitisation and chronic pain syndromes. However, emerging evidence is reshaping our understanding of its underlying mechanisms. This webinar will explore exciting new paradigms in fibromyalgia etiopathogenesis, focusing on the roles of immunity, autoimmunity, and small nerve fib...

These recent papers describe work in the field of stromal cell biology. Fibroblasts were long regarded as simple structural cells and often ignored by immunologists. In these studies of human disease Chris Buckley discusses how recent approaches based on transcriptomics have shone new light on these cells and their role in disease. Given their long lived nature and capacity to remain resident in t...

Artificial Intelligence is transforming medicine, from diagnostics and drug discovery to personalised treatment and predictive analytics. But alongside its promise come some important challenges: Algorithmic bias, data privacy, accountability and the tension between human judgment and machine intelligence. This webinar brings together medical scientists and academic physicians to explore the reali...

Immune thrombocytopenia (ITP) is a rare autoimmune disease, but also one where a great deal of progress has been made in development of new therapies. Prof Cooper performs clinical trials to understand the impact of new therapies, based upon and also gaining insights into the underlying pathogenesis. The clear readout of platelet count allows for a trial design which can funnel diverse new types o...

Mark Hull talks about the translational research development of the n-3 PUFA EPA as a cancer prevention agent through to phase 2 and 3 clinical trials, touching on design and delivery of trials of ‘nutraceuticals’ like high-dose n-3 PUFAs, and how such an intervention might impact on cancer. Despite proof of concept from a small, randomised trial of EPA in patients with familial adenomatous polypo...

The Association of Physicians of Great Britain and Ireland presents a discussion with key world leading experts in Malaria vaccines from the World Health Organisation and Oxford. Focusing on how vaccines are transforming Malaria prevention globally. Specifically, looking at the development and implementation of malaria vaccines. Speakers: Malaria vaccine pilot implementation and results (Mary Hame...

Immune Mediated Inflammatory Diseases (IMIDs) are a common and growing problem. Traditional models of research and service delivery silo their management within specific specialities and within adult or paediatric settings. Very often patients with disease in one organ have co-morbid involvement in another, suggesting shared pathogenic pathways. Moreover, IMIDs are often treated in very similar wa...

In this podcast Professor Sir Pirmohamed describes how his work in immunopharmacology has impacted drug therapy in the field of oncology. His work is impacted the lives of thousands of patients receiving potentially toxic therapies and shows the power of genomic medicine in helping make real-world clinical decisions. Professor Paul Klenerman Sidney Truelove Professorship of Gastroenterology, Nuffi...

The Association of Physicians of Great Britain and Ireland presents a comprehensive exploration of diabetes complications, hosted by Dr Uazman Alam, Reader at the University of Liverpool and Honorary Consultant Physician in Internal Medicine, Diabetes and Endocrinology. Professor Gregory Lip examines the critical relationship between atrial fibrillation and diabetes, highlighting SGLT2 inhibitors&...

Welcome to the Association of  Physicians (AoP) podcast series AoPcasts: Bringing you the latest in medical research. The AoPcasts is a fascinating series of podcasts bringing cutting edge medical research to new audiences.  Produced by the AoP and hosted by science broadcaster Vivienne Parry, the series will explore some of the major themes debated at the annual AoP meeting.   The first AoPcast b...

Welcome to our first episode of AoPcasts: Bringing you the latest in medical research. The AoP membership is now open to all interested in the translational research effort; with AoPcasts we aim to extend this ethos by sharing insights, experience and guidance from the experts from our field to our community.    In this episode, hosted by Vivienne Parry OBE ,  Dr. Rino Rappuoli and Professor Ellie...