ANA Investigates

Burnt out by talking about burnout? Please join us for a podcast with Dr. Amy Arnsten, Professor of Neuroscience and Psychology at Yale University, to investigate what goes on in the brain that leads to burnout and how this can direct our efforts to reduce burnout. Series 3, Episode 6. Featuring: Guest: Dr. Amy Arnsten, Professor of Neuroscience and Psychology at Yale University - Interviewer/Prod...

On today's show, we'll focus on the future of biomarkers in Alzheimer's disease. We know that amyloid beta and tau protein deposit long before patients with Alzheimer's develop symptoms. If we could use biomarkers to detect this pathology early, and treat patients early, could we prevent the progression to dementia? Our guests today are leaders in the development of biomarkers for Alzheimer's dise...

Can coma be "cured"? On this podcast, we talk to Dr. Claude Hemphill and Dr. Romer Geocadin of the Curing Coma Campaign. Series 3, Episode 4 https://www.curingcoma.org/events2/world-coma-day Featuring: Guests: Romer Geocadin, MD, Johns Hopkins University & Claude Hemphill, MD, University of California San Francisco Interviewer/Producer: Dr. Adeline Goss Disclosures: None Below are articles the gue...

Treatment of stroke has changed dramatically in the past decade, with the advent of perfusion imaging and an expanded time window for mechanical thrombectomy. Thrombectomy is now standard of care for eligible patients. But while data clearly supports the use of thrombectomy for certain patients with anterior circulation strokes, the benefit of thrombectomy for patients with basilar artery occlusio...

On today's show we'll focus on functional neurological disorder, or FND -- a wide range of conditions including non-epileptic seizures and functional weakness, dystonia and tremor. These conditions are common and can cause serious disability. But what are these conditions, exactly? What have functional neuroimaging and other tools taught us about their pathophysiology, diagnosis, and treatment? Se...

Some patients with medically refractory epilepsy are offered surgeries to implant devices that electrically stimulate the nervous system and actually modulate neural networks over time. On this episode of ANA Investigates, Dr. Vikram Rao of the UCSF Weill Institute for Neurosciences discusses how these neurostimulation devices can reduce seizure burden, along with a range of other potential benefi...

Autonomic dysfunction often presents with subtle symptoms affecting multiple organ systems simultaneously. On this episode of ANA Investigates, we discuss bedside evaluation and advanced workup of dysautonomia and how to manage refractory symptoms. Series 2, Episode 11. Featuring: Guest: Safwan Jaradeh, MD, Professor of Neurology, Psychiatry and Behavioral Sciences and Director of the Autonomic Di...

In July, the World Health Organization released its updated classification of Tumors of the Central Nervous System. The last update was in 2016. The update reflects the increasing role of molecular biomarkers in tumor characterization -- a change that has major implications for how we diagnose and treat patients with brain and spinal cord tumors. Joining us today to help us understand these change...

In recent years, the Food and Drug Administration approved several new treatments specifically for the treatment of multiple sclerosis and neuromyelitis optica spectrum disorder. But what about neuroimmunological conditions that do not have FDA approved options and require off-label use of immunomodulatory medications -- conditions like neurosarcoidosis, neuro-Behcet's, or central nervous system i...

For much of the history of neurology, diagnosing a genetic disease meant giving bad news. Genetic meant incurable, often fatal. On past shows, we've talked about how this narrative is changing for certain monogenic diseases like Huntington's Disease, where emerging gene therapies offer hope for a cure. But what hope can the field of neurogenetics offer to patients with more complex diseases with b...

Neurology and psychiatry: two fields, one organ system. Today, we'll focus on the intersection between the two. We'll discuss one common psychiatric disease -- depression -- and how new treatments for depression may inform how we treat other neurologic illnesses. ANA Investigates Producer Dr. Rohit Das interviewed Dr. Helen Mayberg, behavioral neurologist at the Icahn School of Medicine at Mt. Sin...

Current guidelines for management of carotid stenosis are based on a series of trials dating back to the 1990s. If you ask today's guests, virtually no other area of neurology is so badly in need of an update. Dr. Seemant Chaturvedi, the Stewart Greenebaum Endowed Professor of Stroke Neurology at University of Maryland School of Medicine, and Dr. Cheryl Bushnell is Professor of Neurology, Vice Cha...

The topic of today's podcast is tenecteplase. This is a thrombolytic drug that is administered intravenously, for certain patients who present to the hospital with an acute ischemic stroke.  There is mounting evidence that intravenous tenecteplase is at least as safe and effective as intravenous alteplase, the current standard of care in ischemic stroke. Tenecteplase also less expensive and easier...

Less than a year -- that's how long it took between when the novel coronavirus emerged and when a vaccine was available to prevent it. This incredible speed of vaccine development exemplifies scientific innovation in a time of crisis. There is increasing vaccine acceptance among the public, but questions about target populations, mechanisms, and side effects remain. Neurological complications have...

The past year has forced us all to contend with the devastating power of infectious disease. The daily, mortal fear of infection is a new experience for many people in the developed world. But that fear characterizes life for millions of people around the globe -- including those who have already lived through plagues or lost loved ones to curable infections. These infections disproportionately ta...

In this episode, we'll introduce you to the next generation of ANA scientists. You may remember a new event at this year's ANA conference called the Emerging Scholars sessions, where we heard presentations from our junior ANA members about their cutting edge research. Those talks were judged based on scientific merit and presentation quality.... and today we'll introduce you to the four winners. ...

This is an exciting moment in the management of a devastating neurologic condition -- Huntington's Disease. As we know, this genetic disease often hits patients at the prime of life and, because it is autosomal dominant, can be haunting for affected families. As we'll discuss today, new developments in biomarkers and therapies for Huntington's are converging into a more hopeful picture for those a...

Today's show is on the science of sleep. Specifically, how sleep – or too little of it – affects the growing brains of adolescents. Why do teenagers stay up so late? What sleep schedules are optimal for their learning? We'll hear from two world experts in adolescent sleep -- Dr. Beth Malow and Dr. Frances Jensen. Dr. Malow is a Professor of Neurology and Pediatrics at Vanderbilt, and the Burry Cha...

This is an exciting moment in the field of neuro-genetics. Advances in gene therapy are opening up new avenues to treating certain genetic forms of otherwise fatal and incurable diseases like ALS and dementia. This may give genetics a bigger role in the daily clinical practice of many adult neurologists. Today we'll learn about this frontier in neuro-genetics from Dr. Bryan Traynor at the National...

Today, in recognition of Alzheimer's and Brain Awareness month, we'll hear from Dr. David Holtzman, professor and chair of neurology at Washington University in St Louis. Dr. Holtzman's work has helped to clarify the relationship between Apolipoprotein E4, or apoE4, and Alzheimer's disease. He is also working to develop CSF biomarkers for Alzheimer's, and he has worked on the development of anti-a...

During this special jointly-produced ANA-AUPN episode, Dr. Clifton Gooch, AUPN president and Dr. Justin McArthur, ANA president discuss how their institutions and departments are approaching operations amid COVID-19, as well as sliver linings they see resulting from the unavoidable shift to virtual operations both clinically and in research. Series 1, Episode 12 **Join the ANA today to attend ANA2...

In this episode, we'll visit the frontiers of vascular neurology, discussing an important but little-understood category of strokes — embolic strokes of undetermined source, or ESUS. We'll hear from Dr. Hooman Kamel, division chief of neurocritical care at Weill Cornell Medicine. Dr. Kamel is a co-principal investigator for the ARCADIA trial, which is testing anti-thrombotic strategies in patients...

The coronavirus pandemic has dramatically changed neurologists' lives -- both at work and at home. Neurologists are taking on new roles and interfacing with patients in new ways, while our work poses new risks to us and our families. How are clinical neurologists adapting and coping in a time of such change? That's the focus of today's special episode. Dr. Adeline Goss was joined by three co-produ...

In this episode, Dr. Jim Siegler interviews Dr. Marc Simard on the management of patients with large hemispheric strokes and cerebral edema. This is a particularly devastating condition: the mortality rate is as high as 50-80 percent at 1 year with medical management alone. Decompressive craniectomy can improve survival for some patients, but most survivors are left with major disability. To date,...

ANA Investigates podcast is brought to you by ANA members, for ANA members, and that is never more true than it is today. In response to this ever-evolving coronavirus pandemic, ANA members have come together to bring you this special episode of ANA investigates recorded this morning addressing the neurological impact of COVID-19. As the number of infections swells worldwide, more patients with th...