Addiction Medicine Journal Club

19. Patients’ Goals in Treatment In episode 19 we discuss an article about what is most important to patients in treatment for opioid use disorder. Reed, M.K., Smith, K.R., Ciocco, F. et al. Sorting through life: evaluating patient-important measures of success in a medication for opioid use disorder (MOUD) treatment program. Subst Abuse Treat Prev Policy 18, 4 (2023).  Also, here are the DEA’s pr...

In episode 18 we discuss the Hepatitis C Real Option (HERO) Study about two different models of HCV treatment in people who inject drugs.   Litwin AH, Lum PJ, Taylor LE, Mehta SH, Tsui JI, Feinberg J, Kim AY, Norton BL, Heo M, Arnsten J, Meissner P, Karasz A, Mckee MD, Ward JW, Johnson N, Pericot-Valverde I, Agyemang L, Stein ES, Thomas A, Borsuk C, Blalock KL, Wilkinson S, Wagner K, Roche J, Murr...

In episode 17 we discuss buprenorphine-naloxone vs. buprenorphine alone in pregnancy. Perry, Briana N. MD; Vais, Simone MD; Boateng, Jeffery O. MBchB, MPH; Jain, Mayuri MPH; Wachman, Elisha M. MD; Saia, Kelley A. MD. Buprenorphine-naloxone Versus Buprenorphine for Treatment of Opioid Use Disorder in Pregnancy. Journal of Addiction Medicine 16(6):p e399-e404, 11/12 2022. We also discuss opioid-indu...

16. Treating Opioid Use Disorder in Jail In episode 16 we discuss an article about in-jail medication for opioid use disorder and recidivism. Elizabeth A. Evans, Donna Wilson, Peter D. Friedmann. Recidivism and mortality after in-jail buprenorphine treatment for opioid use disorder. Drug and Alcohol Dependence, Volume 231, 2022, 109254, ISSN 0376-8716. Scott, C.K., Grella, C.E., Dennis, M.L. et al...

In episode 15 we discuss buprenorphine vs. methadone in pregnancy. E.A. Suarez, K.F. Huybrechts, L. Straub, S. Hernández‑Díaz, H.E. Jones, H.S. Connery, J.M. Davis, K.J. Gray, B. Lester, M. Terplan, H. Mogun, and B.T. Bateman. Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. N Engl J Med 2022; 387:2033-2044.  Bruzelius E, Martins SS. US Trends in Drug Overdose Mortality Among P...

In episode 14 we discuss the connection between early life trauma, depression, anxiety, stress, and opioid use disorder. Effects of Early Life Trauma on Risks for Adult Opioid Use Disorder Are Mediated by Stress and Occur Independent of Depression and Anxiety. Dunn, Kelly E. PhD, MBA; Turner, Gavin M. BS; Oswald, Lynn M. PhD. Journal of Addiction Medicine: 11/12 2022 - Volume 16 - Issue 6 - p 709-...

In episode 13 we discuss opioids and cognitive changes in older adults. Warner, NS, Hanson, AC, Schulte, PJ, Habermann, EB, Warner, DO, Mielke, MM. Prescription opioids and longitudinal changes in cognitive function in older adults: A population-based observational study. J Am Geriatr Soc. 2022; 1- 12. doi:10.1111/jgs.18030 https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.18030 --------...

In episode 12 we discuss overdoses related to methamphetamine and opioid use in rural areas. Korthuis PT, Cook RR, Foot CA, et al. Association of Methamphetamine and Opioid Use With Nonfatal Overdose in Rural Communities. JAMA Netw Open. 2022;5(8):e2226544. doi:10.1001/jamanetworkopen.2022.26544 August 2022 Rural Opioid Initiative ---------- We also discuss building community in addiction medicine...

In episode 11 we discuss an article about the impact of wine bottle and glass size on consumption. Mantzari, E, Ventsel, M, Ferrar, J, Pilling, MA, Hollands, GJ, Marteau, TM. Impact of wine bottle and glass sizes on wine consumption at home: a within- and between- households randomized controlled trial. Addiction. 2022.  ---------- We discuss non-abstinence-based resources for addressing unhealthy...

Short on time? In this episode we give you quick summaries of articles 1-10. Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease Analysis of Stimulant Prescriptions and Drug-Related Poisoning Risk Among Persons Receiving Buprenorphine Treatment for Opioid Use Disorder Association of Dose Tapering With Overdose or Mental Health Crisis Among Patients Prescribed Long-term Opioi...

In episode 10 we discuss an article about buprenorphine tapering. Bozinoff N, Men S, Kurdyak P, Selby P, Gomes T. Prescribing Characteristics Associated With Opioid Overdose Following Buprenorphine Taper. JAMA Netw Open. 2022;5(9):e2234168. ---------- Take a look at Riggs, KR, DeRussy, AJ, Leisch, L, et al. Sensitivity of health records for self-reported nonfatal drug and alcohol overdose. Am J Ad...

In episode 9 we discuss psilocybin for treating alcohol use disorder. Bogenschutz MP, Ross S, Bhatt S, et al. Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2022;79(10):953–962. ---------- We talk about Wal-Mart and CVS not filling some telemedicine...

In episode 8 we discuss the article about opioid tapering and discontinuation, and the risks of suicide and overdose. Larochelle MR, Lodi S, Yan S, Clothier BA, Goldsmith ES, Bohnert ASB. Comparative Effectiveness of Opioid Tapering or Abrupt Discontinuation vs No Dosage Change for Opioid Overdose or Suicide for Patients Receiving Stable Long-term Opioid Therapy. JAMA Netw Open. 2022;5(8):e2226523...

In Episode 7 we discuss treating opioid use disorder with co-occurring polysubstance use. Xu KY, Mintz CM, Presnall N, Bierut LJ, Grucza RA. Comparative Effectiveness Associated With Buprenorphine and Naltrexone in Opioid Use Disorder and Cooccurring Polysubstance Use. JAMA Netw Open. 2022;5(5):e2211363. 2022 Aug 3. We also discuss the Society of Hospital Medicine’s new consensus statement about m...

In episode 6 we discuss a benzodiazepine-sparing alcohol withdrawal protocol. Smith JT, Sage M, Szeto H, et al. Outcomes After Implementation of a Benzodiazepine-Sparing Alcohol Withdrawal Order Set in an Integrated Health Care System. JAMA Netw Open. 2022;5(2):e220158. 2022 Feb 2. We also discuss long-term outcomes from a primary-care based MAT clinic, and the movement to deregulate methadone and...

Episode 5 discusses the clinical effects of getting a medical marijuana card. Gilman JM, Schuster RM, Potter KW, et al. Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(3):e222106. If you want an introduction on how to manage medical marijuana in primary care, listen to this awesome episode...

Episode 4 discusses the benefits of smoking cessation after a diagnosis of lung cancer. Mahdi Sheikh, Anush Mukeriya, Oxana Shangina, et al. Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality: A Prospective Cohort Study. Ann Intern Med.2021;174:1232-1239. [Epub 27 July 2021]. We also talk about whether or not increased buprenorphine prescribing will lead pat...

In episode 2 we discuss the safety of prescribing stimulants for patients receiving buprenorphine. Article Citation: Mintz CM, Xu KY, Presnall NJ, et al. Analysis of Stimulant Prescriptions and Drug-Related Poisoning Risk Among Persons Receiving Buprenorphine Treatment for Opioid Use Disorder. JAMA Netw Open. 2022;5(5):e2211634. doi:10.1001/jamanetworkopen.2022.11634 We also discuss marketing of f...

In episode 3 we discuss the risks of tapering for patients on long-term, high-dose opioids. Article citation: Agnoli, A., Xing, G., Tancredi, D. J., Magnan, E., Jerant, A., & Fenton, J. Association of Dose Tapering With Overdose or Mental Health Crisis Among Patients Prescribed Long-term Opioids. JAMA, 326(5), 411–419. August 3, 2021. We also discuss how to get your DEA waiver to prescribe bupreno...

In Episode 1 we discuss the article “Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease,” a reexamination of the question of how alcohol intake is related to cardiovascular outcomes, and whether or not the J-curve for risks of alcohol intake actually exists. Article citation: Biddinger KJ, Emdin CA, Haas ME, et al. Association of Habitual Alcohol Intake With Risk of Cardiov...