about enzymes & molecules

#9 - Inflammatory Diseases - Dr. Nathalie Vergnolle

In this episode of our Special Interviews Series with Institute Directors, we spoke to Dr Jean-Sébastien Silvestre, recently appointed Director of the Paris-Centre de Recherche Cardiovasculaire (PARCC, 2023-present). Dr Silvestre has a clear view of how to implement a successful research strategy at PARCC. He told us about the continuous dialogue with his team leaders, research technical staff and...

In the second episode of our Special Interviews Series with Institute Directors we invited Dr Alain Tedgui, former Director of the Paris-Centre de Recherche Cardiovasculaire (PARCC, 2009-2018). Dr Tedgui gave us a wonderful overview of the strategies behind the founding of PARRC as a major French scientific institute dedicated to study cardiovascular disease as well as the original plans that were...

The topic of our discussion today is environmental stress and how it affects our susceptibility to develop diseases. We are familiar with the danger of air pollution, which increases lung disease and is being implicated in neurodegeneration or cardiovascular disorders, but we often do not consider noise, which is a very important external stressor. We are surrounded by noise, especially in the urb...

This is the first episode of our Special Interviews Series with Institute Directors, where we discuss the opportunities and challenges that come with being in charge of a research institute. The expertise required for this job is multi-varied: the director needs to develop ambitious research goals by relying on their teams' skills and scientific interests, leveraging the input of technical pla...

For our fourth episode we will talk about a special system that is very important for protecting the organism against stress: the NRF2 transcription factor. It is the master regulator of the stress response, which is responsible for increasing the expression of a long list of genes that help to combat stress and restore cellular homeostasis. Interestingly, NRF2 is activated by stressful stimuli bu...

In the 3rd episode of this series, Dr Vinchi and I will talk about different facets of heme biology, why heme is crucial in normal physiology and why it exerts a deleterious action when it is not tightly bound to a protein. We will further examine the modulatory role of heme in diseases characterized by excessive free heme in circulation and how endothelial cells in vessels and specific immune cel...

In the second episode of our podcast 'about enzymes & molecules', we welcome Dr Roland Stocker to talk about bilirubin, the antioxidant molecule produced during heme breakdown by heme oxygenase. Dr Stocker will tell us about the inspiration that led to hypothesize that bilirubin possesses antioxidant properties, the thorough methodological approaches that were required to precisely dem...

Welcome to the science podcast about enzymes & molecules , where we will discuss the fascinating world of enzymes & molecules and their role in nature and human biology. I am Dr. Roberta Foresti, professor of Biochemistry at the University of Paris Est Créteil and working as a scientist at the Mondor Institute of Biomedical Research in France. During the podcast we will be exploring severa...

Welcome to the first episode of the science podcast about enzymes & molecules. Today we welcome our first guest, Leo Otterbein , PhD, Professor of Surgery and principal investigator of the Otterbein Lab at Harvard Medical School in Boston, USA. Dr. Otterbein has published fundamental findings on heme oxygenase and its product, carbon monoxide, establishing the crucial role of this system in in...