Paper Talk

This is an excerpt from a review article titled "The Role of Neuroinflammation in Neurological Diseases," co-authored by Fu Dongshi and V. Wee Yong, published in Science magazine. The article explores the role of neuroinflammation in various neurological diseases (such as multiple sclerosis, stroke, Alzheimer's disease, and Parkinson's disease). It elaborates in detail on how immune cell infiltrat...

This resource article introduces Perturb-Multimodal (Perturb-Multi), an innovative platform integrating imaging and sequencing for pooled genetic screening in intact mammalian tissues. The method captures in situ genotypes and multiple RNA-protein phenotypes through RCA-MERFISH, and enables in vivo CRISPR screening while preserving complete transcriptomes through fixed-cell Perturb-seq. The articl...

"The Neuroimmune Connectome in Health and Disease" explores the complex interactions between the nervous system and immune system, emphasizing the importance of these connections, known as the neuroimmune connectome, in health, disease development (especially neurodegenerative diseases), and behavior regulation. The article outlines current understanding of neuroimmune communication, including the...

These are excerpts from articles in Nature journal and its related news and opinion sections, mainly focusing on the impact of diet and gut microbiome on health. Specifically, they explore how calorie restriction delays aging through bile acids, and how a molecule produced by gut bacteria promotes arterial plaque formation, thereby increasing cardiovascular disease risk. Additionally, the articles...