Immune

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this epis...

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Intestinal IgA regulates neuroinflammation (Cell) Time stamps by Jol...

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CAR-T...

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Christian Gaebler Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Evolution of antibody immunity to...

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Madina Wane Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  o...

Immune reminisces about a year in COVID-19 immunology, Steph's receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron...

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Imm...

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Sallie Permar Subscribe (free):  iTunes...

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guests: Alexis Mobley , Joel Babdor , Elaine Kouame , Justine Noel , Ev...

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Guest: Alexander Dent Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  ema...

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses. Hosts:  Vincent Racaniello , Stephanie Langel , Cynthia Leifer , and Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode COVID-19...

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. Hosts:  Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Cross-reactive coro...

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts:  Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CD8 cells defend against SARS-CoV (J Virol) Deep immune pr...

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for th...

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode How...

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode IL6 as COVI...

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Brianne Barker Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode ACE2 in oral mucosa (I J Oral Sci) IL6 pre...

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Irene Salinas Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Evolution of mucosal Ig in rainbow tr...

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode H3K4me1 mark on memory-like NK cells (Cell Rep) Letters read on Immune 27 Time stamps by J...

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Guest: Michael Mina Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Measles virus infection diminishes pre-e...

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode CD8+ T cell memory needs microbiome derived fatty acids (Imm...

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode New type of T helper cell drives anaphylaxis (Science) Image credit Time stamps by Jolene . Thanks! Le...

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene . Thanks! Vaccines and Your Child Lette...

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene . Thanks! Letters read on...

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts:  Vincent Racaniello , Stephanie Langel , and Cynthia Leifer Subscribe (free):  iTunes ,  Google Podcasts .  RSS ,  email Become a  patron  of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time...