Evidence Based Medicine presented by InpharmD™

An investigator-initiated, multi-center, randomized, double-blind, superiority, placebo-controlled conducted to determine whether the combination of vasopressin and methylprednisolone administered during in-hospital cardiac arrest improves return of spontaneous circulation.

A randomized, adaptive, platform trial conducted to assess the efficacy of fluvoxamine versus placebo in preventing hospitalization (defined as either retention in a COVID-19 emergency setting or transfer to a tertiary hospital due to COVID-19). 

A randomized, double-blind, placebo-controlled, phase 3 study, conducted to evaluate the efficacy and safety MDMA-assisted therapy for PTSD compared with placebo with therapy?

A randomized, double-blind, parallel-group, placebo-controlled, event-driven trial conducted to evaluate the effects of SGLT2 inhibition with empagliflozin on major heart failure outcomes in patients with heart failure and a preserved ejection fraction.

This week, InpharmD looks at two case reports discussing presentations of patients who developed Functional Neurological Disorder (FND) after receiving COVID-19 vaccination. 

This week, we look at two different case reports: 1) Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination 2) Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination Tune in to learn more!   

A cohort study conducted to determine whether there is a dose–response relationship between the intensity of exposure to the World Trade Center (WTC) site and the risk of hepatic steatosis (HS) in the WTC General Responder Cohort (GRC).

A prospective, multi-center, international cohort study conducted to evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD), Crohn's Disease, and Ulcerative Colitis.

A double-blind, placebo-controlled, cross-over study conducted to assess the impact of childhood trauma on responses to morphine and pain processing. 

A study that use supervised machine learning to identify potential variables important to assessing risk of incident chronic heart disease (CHD), stroke, and heart failure (HF) in a hypothesis-free, data-driven manner.

A study conducted to investigate the acceptability and tolerability of an intra-oral device, designed to facilitate weight loss

Here we provide an overview of three case reports focusing on patients who developed rhino-orbital mucormycosis, a rare fungal infection, potentially from COVID-19. 

A multicenter, randomized, open-label, parallel-group trial conducted to determine the effectiveness of continuous glucose monitoring (CGM) in adults with type 2 diabetes treated with basal insulin. 

An international, randomized, double-blind, placebo-controlled trial conducted to evaluate the efficacy and safety of semaglutide, as compared with placebo, as an adjunct to lifestyle intervention for reducing body weight in overweight and obese adults without diabetes. 

An investigator-initiated, multicenter, parallel-group, open-label, randomized clinical trial conducted to determine whether continuous infusion of hypertonic saline solution improves neurological outcomes at 6 months in patients with traumatic brain injury

A global, phase-3 trial conducted to  evaluate the efficacy and safety of sacituzumab govitecan (Trodelvy) as compared with single-agent chemotherapy of the physician's choice in patients with relapsed or refractory metastatic triple-negative breast cancer. This trial led to the FDA's accelerated approval of Trodelvy for this indication. 

A mutlicenter, randomized trial conducted to test whether dexmedetomidine leads to better short-term and long-term outcomes than propofol in mechanically ventilated adults with sepsis.

A randomized, multicenter, international, double-blind, placebo-controlled trial conducted to determine whether the addition of midodrine to standard care reduces the time to discontinuation of IV vasopressor use in otherwise resuscitated patients

A retrospective, multicenter, observational, database analysis conducted to quantify rates of organ-specific dysfunction in individuals with COVID-19 after discharge from hospital compared with a matched control group from the general population

A randomized, open-label, trial conducted to evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU).

A retrospective, observational, cohort study conducted to compare the rate of change in estimated glomerular filtration rate (eGFR) after hospital discharge between patients with and without COVID-19 who experienced in-hospital acute kidney injury (AKI)

A randomized study conducted to determine the effect of bamlanivimab monotherapy and combination therapy with bamlanivimab and etesevimab on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) viral load in mild to moderate COVID-19

A controlled, open-label trial conducted to report the results of the controlled, open-label Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial of dexamethasone in patients hospitalized with COVID-19.

A randomized multicenter, double-blind, parallel-group, placebo-controlled trial, conducted to investigate the effect of vitamin D 3 administration on hospital length of stay and other relevant clinical outcomes and adverse events in hospitalized patients with moderate to severe COVID-19. 

A randomized, multi-center, open-label, open-label, factorial clinical trial conducted to examine whether high-dose zinc and/or high-dose ascorbic acid reduce the severity or duration of symptoms compared with usual care among ambulatory patients with SARS-CoV-2 infection.