Aging Podcast
Aging-US
Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease. Read about the Aging Scientific Integrity Process: https://aging-us.com/scientific-integrity
Koniecznie odwiedź stronę podcastu i wesprzyj twórcę: www.aging-us.com
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PR55α-controlled PP2A Inhibits p16 Expression and Blocks Cellular Senescence Induction 19.03.2024 4:47
BUFFALO, NY- March 19, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.” Cellular senescence is a permanent cell cycle arrest that can be triggered by both int...
Age Prediction Models in the Human Brain: Genome-wide Transcriptome Profiling and Development 15.03.2024 3:50
BUFFALO, NY- March 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, “Genome-wide transcriptome profiling and development of age prediction models in the human brain.” Aging-related transcriptome changes in various regions of the healthy human brain have been explor...
Behind the Study: Mapping of Gene Network That Regulates Glycan Clock of Aging 13.03.2024 8:19
Dr. Azra Frkatović-Hodžić from Genos Glycoscience Research Laboratory in Zagreb, Croatia, discusses a #research paper she co-authored that was #published by Aging (Aging-US) in Volume 15, Issue 24, entitled, “Mapping of the gene network that regulates glycan clock of ageing.” DOI - https://doi.org/10.18632/aging.205106 Corresponding authors - Azra Frkatović-Hodžić - afrkatovic@genos.hr, and Gordan...
Transcriptomic Modulation of Alzheimer’s Disease by Activated Protein C Using Single-Cell RNA-Seq 13.03.2024 3:16
BUFFALO, NY- March 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C.” Single-Cell RNA sequencing reveals changes in cell population in Alzheimer’s disease (AD) model 5xFAD (5x Fa...
Association of Prenatal Vitamins and Metals With Epigenetic Aging at Birth and in Childhood 12.03.2024 3:23
BUFFALO, NY- March 12, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort.” Epigenetic gestational age acceleration (EGAA) at birth and epigen...
Aging at AACR Annual Meeting 2024 11.03.2024 2:08
BUFFALO, NY- March 11, 2024 – Impact Journals #publishes scholarly #journals in the #biomedical sciences with a focus on all areas of cancer and aging research. Aging is one of the most prominent journals published by Impact Journals. Impact Journals will be participating as an exhibitor at the American Association for Cancer Research (AACR) Annual Meeting 2024 from April 5-10 at the San Diego Con...
Behind the Study: Analyzing Psoriasis Communication Patterns for Treatment Optimization 11.03.2024 8:53
Dr. Jiajian Wang from Sun Yat-Sen University, The Chinese University of Hong Kong, the Chinese Academy of Sciences, and the Shenzhen Key Laboratory of Metabolic Health, describes a #research paper he co-authored and #published in Aging’s Volume 16, Issue 3, entitled, “Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern rec...
Overcoming Missing Data in the Swedish National Study on Aging 07.03.2024 7:54
Missing data in aging studies, especially in the assessment of gait speed (the time it takes individuals to cover a set distance), presents a significant challenge. The elderly are more prone to health and functional issues, which often interfere with data collection efforts. Given that gait speed is a key indicator of functional status and overall health in older individuals, ensuring its availab...
A Longitudinal Study on Dasatinib, Quercetin, and Fisetin Senolytic Interventions 06.03.2024 3:42
BUFFALO, NY- March 6, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions.” Senolytics, small molecules targeting cellular senescence, have emerged as...
A Call for Standardization of Controls in Lifespan Studies 05.03.2024 3:00
BUFFALO, NY- March 5, 2024 – A new #research perspective was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “On standardization of controls in lifespan studies.” In this new paper, researchers Olga Spiridonova, Dmitrii Kriukov, Nikolai Nemirovich-Danchenko, and Leonid Peshkin from Harvard Medical School's Departm...
Mapping the Core Senescence Phenotype of Human Colon Fibroblasts 29.02.2024 3:30
BUFFALO, NY- February 29, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.” Advanced age is the largest risk factor for many diseases and several types of cancer, including colorectal cancer (CR...
Prognostic Model Development and Molecular Subtypes Identification in Bladder Urothelial Cancer 28.02.2024 5:55
BUFFALO, NY- February 28, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “Prognostic model development and molecular subtypes identification in bladder urothelial cancer by oxidative stress signatures.” Mounting studies indicate that oxidative stress (OS) significantly contributes...
The Anti-aging Effect of Vitamin D and its Receptor in Drosophila Midgut 27.02.2024 3:24
BUFFALO, NY- February 27, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut.” Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging and its assoc...
Disruption of mtUPR Results in Telomere Shortening in Mouse Oocytes and Somatic Cells 21.02.2024 3:18
BUFFALO, NY- February 21, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “Disruption of mitochondrial unfolded protein response results in telomere shortening in mouse oocytes and somatic cells.” Caseinolytic peptidase P (CLPP) plays a central role in mitochondrial unfolded protein...
Defining the Progeria Phenome 20.02.2024 3:01
BUFFALO, NY- February 20, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “Defining the progeria phenome.” Progeroid disorders are a heterogenous group of rare and complex hereditary syndromes presenting with pleiotropic phenotypes associated with normal aging. Due to the large var...
Aging’s Top 10 Papers in 2023 (Crossref Data) 15.02.2024 7:59
Crossref is a non-profit organization that logs and updates citations for scientific publications. Each month, Crossref identifies a list of the most popular Aging (Aging-US) papers based on the number of times a DOI is successfully resolved. Below are Crossref’s Top 10 Aging DOIs in 2023. 10: Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant met...
GV1001 Reduces Neurodegeneration and Prolongs Lifespan in Mouse Model of Alzheimer’s Disease 15.02.2024 3:44
BUFFALO, NY- February 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects.” GV1001, which mimics the activity of human telomerase reverse transcriptase, protects...
IL-17 Promotes IL-18 Production in Osteoarthritis Synovial Fibroblasts Via… 13.02.2024 4:19
BUFFALO, NY- February 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.” The concept of osteoarthritis (OA) as a low-grade inflammatory joint disorder has been widely accepted....
PROX1/α-SMA Correlated With Colorectal Cancer Progression, Poor Outcomes and Therapeutic Resistance 07.02.2024 4:03
BUFFALO, NY- February 7, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance.” The tumor microenvironment (TM...
Epigenetic Drift Underlies Epigenetic Clock Signals, but… 06.02.2024 3:01
BUFFALO, NY- February 6, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation.” Changes in DNA methylation with age are observed a...
Senescence-Related TME Genes as Key Prognostic Predictors in HNSCC 01.02.2024 8:12
Head and neck squamous cell carcinoma (HNSCC) is a prevalent and heterogeneous form of cancer that affects thousands of individuals worldwide. The prognosis for HNSCC patients can vary greatly, depending on factors such as tumor stage and site. The tumor microenvironment (TME) plays a crucial role in tumorigenesis and disease progression, with cellular senescence being a key component. Senescent c...
Prognostic Significance of Senescence-related TME Genes in Head and Neck Squamous Cell Carcinoma 31.01.2024 3:34
BUFFALO, NY- January 31, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma.” The impact of the senescence related microenvironment on cancer prognosis an...
XRCC1: A Potential Prognostic and Immunological Biomarker in Low-Grade Gliomas 30.01.2024 3:47
BUFFALO, NY- January 30, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis.” X-ray repair cross-complementation group 1 (XRCC1) is a pivotal contributor to base excision repair,...
Targeting FSP1 Regulates Iron Homeostasis in Drug-tolerant Persister Head and Neck Cancer Cells 24.01.2024 4:27
BUFFALO, NY- January 24, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis.” Research has demonstrated that some tumor cells can transform into...
Systematic Analysis of the Prognostic Value and Immunological Function of LTBR in Cancer 23.01.2024 4:17
BUFFALO, NY- January 23, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “Systematic analysis of the prognostic value and immunological function of LTBR in human cancer.” Lymphotoxin beta receptor (LTBR) is a positive T cell proliferation regulator gene. It is closely associated wi...
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